P87218 (SOU2_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sorbose reductase homolog SOU2
EC=1.1.-.-

Gene names

Name:	SOU2
ORF Names:	CaO19.10415, CaO19.2897

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Unknown. The enzyme has no activity toward sorbose.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	Sorbose reductase homolog SOU2		PRO_0000054778
Regions
	Nucleotide binding	41 – 63	23	NAD By similarity
Sites
	Active site	188	1	Proton acceptor By similarity
	Binding site	173	1	Substrate By similarity
Natural variations
	Natural variant	129 – 130	2	EI → KF in strain: SOR17.
	Natural variant	191	1	A → R in strain: SOR17.
	Natural variant	202 – 203	2	LS → FT in strain: SOR17.
	Natural variant	280	1	V → I in strain: SOR17.

Sequences

	Sequence		Length	Mass (Da)
	P87218 [UniParc]. Last modified January 24, 2006. Version 2. Checksum: ABFA091C75A3D297	FASTA	280	29,878
	10 20 30 40 50 60 MSKETTSYTN AKLGPLPTKA ATIPDNILDA FSLKGKVASV TGSSGGIGWA VAEGYAQAGA 70 80 90 100 110 120 DVAIWYNSHP ADDKAEYLTK TYGVKSKAYK CNVTDFQDVE KVVKQIESDF GTIDIFVANA 130 140 150 160 170 180 GVAWTEGPEI DVKGVDKWNK VVDVDLNSVY YCAHVVGPIF RKKGKGSFIF TASMSASIVN 190 200 210 220 230 240 VPQLQAAYNA AKAGVKHLSK SLSVEWAPFA RVNSVSPGYI ATHLSEFADP DVKSKWLQLT 250 260 270 280 PLGREAKPRE LVGAYLYLAS DAASYTTGAD LAVDGGYTVV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Monosomy of a specific chromosome determines L-sorbose utilization: a novel regulatory mechanism in Candida albicans." Janbon G., Sherman F., Rustchenko E. Proc. Natl. Acad. Sci. U.S.A. 95:5150-5155(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SOR17.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF002134 Genomic DNA. Translation: AAC24462.1. AACQ01000084 Genomic DNA. Translation: EAK96530.1. AACQ01000083 Genomic DNA. Translation: EAK96589.1.
RefSeq	XP_715553.1. XM_710460.1. XP_715609.1. XM_710516.1.
3D structure databases
ProteinModelPortal	P87218.
SMR	P87218. Positions 4-278.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0005254.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3642759. 3642823.
KEGG	cal:CaO19.10415. cal:CaO19.2897.
Organism-specific databases
CGD	CAL0005254. SOU2.
Phylogenomic databases
eggNOG	COG1028.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SOU2_CANAL

Accession

Primary (citable) accession number: P87218
Secondary accession number(s): Q5A1C2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 24, 2006
Last modified:	April 3, 2013
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program