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P87214

- HEM4_SCHPO

UniProt

P87214 - HEM4_SCHPO

Protein

Uroporphyrinogen-III synthase

Gene

ups1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.By similarity

    Catalytic activityi

    Hydroxymethylbilane = uroporphyrinogen III + H2O.

    Pathwayi

    GO - Molecular functioni

    1. uroporphyrinogen-III synthase activity Source: PomBase

    GO - Biological processi

    1. heme biosynthetic process Source: PomBase
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Heme biosynthesis, Porphyrin biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00320.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uroporphyrinogen-III synthase (EC:4.2.1.75)
    Short name:
    UROIIIS
    Short name:
    UROS
    Alternative name(s):
    Hydroxymethylbilane hydrolyase [cyclizing]
    Uroporphyrinogen-III cosynthase
    Gene namesi
    Name:ups1
    Synonyms:ups
    ORF Names:SPAC31G5.08
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC31G5.08.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 251251Uroporphyrinogen-III synthasePRO_0000135253Add
    BLAST

    Proteomic databases

    MaxQBiP87214.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4692815.
    STRINGi4896.SPAC31G5.08-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP87214.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1587.
    HOGENOMiHOG000216635.
    KOiK01719.
    OMAiDKGIAME.
    OrthoDBiEOG7J44HQ.
    PhylomeDBiP87214.

    Family and domain databases

    InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
    [Graphical view]
    PfamiPF02602. HEM4. 1 hit.
    [Graphical view]
    SUPFAMiSSF69618. SSF69618. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P87214-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTALLLKTK SQPFDPYVEA FEKYGRDTAF IPVLRHKRVH EEQLRDKLKN    50
    VRKTYCGLIV TSQRVSETLD EALKQEDETE RQKILMETPI FTVGPATDDS 100
    IRRLGFQQTH GKDCGRGEVL ADLIEEWYTT TKQHKPLLFL VGEKHRDIIQ 150
    RKLGDDRVDS LIVYATQELE NTETQIKDTI RKHPTIDWIV AFSPTSICSL 200
    LNTFELKIAT IGPTTGDYLK KLGTQPNVVS PAPNPESLAS SIVAFDEENS 250
    S 251
    Length:251
    Mass (Da):28,515
    Last modified:July 1, 1997 - v1
    Checksum:i3CA8BC4EA9C04964
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB004551 Genomic DNA. Translation: BAA20416.1.
    CU329670 Genomic DNA. Translation: CAB11692.1.
    PIRiT38625.
    RefSeqiNP_594008.1. NM_001019434.2.

    Genome annotation databases

    EnsemblFungiiSPAC31G5.08.1; SPAC31G5.08.1:pep; SPAC31G5.08.
    GeneIDi2543161.
    KEGGispo:SPAC31G5.08.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB004551 Genomic DNA. Translation: BAA20416.1 .
    CU329670 Genomic DNA. Translation: CAB11692.1 .
    PIRi T38625.
    RefSeqi NP_594008.1. NM_001019434.2.

    3D structure databases

    ProteinModelPortali P87214.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4692815.
    STRINGi 4896.SPAC31G5.08-1.

    Proteomic databases

    MaxQBi P87214.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC31G5.08.1 ; SPAC31G5.08.1:pep ; SPAC31G5.08 .
    GeneIDi 2543161.
    KEGGi spo:SPAC31G5.08.

    Organism-specific databases

    PomBasei SPAC31G5.08.

    Phylogenomic databases

    eggNOGi COG1587.
    HOGENOMi HOG000216635.
    KOi K01719.
    OMAi DKGIAME.
    OrthoDBi EOG7J44HQ.
    PhylomeDBi P87214.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00320 .

    Miscellaneous databases

    NextBioi 20804187.
    PROi P87214.

    Family and domain databases

    InterProi IPR003754. 4pyrrol_synth_uPrphyn_synth.
    [Graphical view ]
    Pfami PF02602. HEM4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69618. SSF69618. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "S.pombe uroporphrinogen III synthase gene."
      Kawamukai M.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiHEM4_SCHPO
    AccessioniPrimary (citable) accession number: P87214
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3