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P87214

- HEM4_SCHPO

UniProt

P87214 - HEM4_SCHPO

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Protein

Uroporphyrinogen-III synthase

Gene

ups1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.By similarity

Catalytic activityi

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathwayi

GO - Molecular functioni

  1. uroporphyrinogen-III synthase activity Source: PomBase

GO - Biological processi

  1. heme biosynthetic process Source: PomBase
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00251; UER00320.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III synthase (EC:4.2.1.75)
Short name:
UROIIIS
Short name:
UROS
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene namesi
Name:ups1
Synonyms:ups
ORF Names:SPAC31G5.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC31G5.08.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251Uroporphyrinogen-III synthasePRO_0000135253Add
BLAST

Proteomic databases

MaxQBiP87214.

Interactioni

Protein-protein interaction databases

MINTiMINT-4692815.
STRINGi4896.SPAC31G5.08-1.

Structurei

3D structure databases

ProteinModelPortaliP87214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1587.
HOGENOMiHOG000216635.
InParanoidiP87214.
KOiK01719.
OMAiDKGIAME.
OrthoDBiEOG7J44HQ.
PhylomeDBiP87214.

Family and domain databases

InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMiSSF69618. SSF69618. 1 hit.

Sequencei

Sequence statusi: Complete.

P87214-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTALLLKTK SQPFDPYVEA FEKYGRDTAF IPVLRHKRVH EEQLRDKLKN
60 70 80 90 100
VRKTYCGLIV TSQRVSETLD EALKQEDETE RQKILMETPI FTVGPATDDS
110 120 130 140 150
IRRLGFQQTH GKDCGRGEVL ADLIEEWYTT TKQHKPLLFL VGEKHRDIIQ
160 170 180 190 200
RKLGDDRVDS LIVYATQELE NTETQIKDTI RKHPTIDWIV AFSPTSICSL
210 220 230 240 250
LNTFELKIAT IGPTTGDYLK KLGTQPNVVS PAPNPESLAS SIVAFDEENS

S
Length:251
Mass (Da):28,515
Last modified:July 1, 1997 - v1
Checksum:i3CA8BC4EA9C04964
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB004551 Genomic DNA. Translation: BAA20416.1.
CU329670 Genomic DNA. Translation: CAB11692.1.
PIRiT38625.
RefSeqiNP_594008.1. NM_001019434.2.

Genome annotation databases

EnsemblFungiiSPAC31G5.08.1; SPAC31G5.08.1:pep; SPAC31G5.08.
GeneIDi2543161.
KEGGispo:SPAC31G5.08.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB004551 Genomic DNA. Translation: BAA20416.1 .
CU329670 Genomic DNA. Translation: CAB11692.1 .
PIRi T38625.
RefSeqi NP_594008.1. NM_001019434.2.

3D structure databases

ProteinModelPortali P87214.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4692815.
STRINGi 4896.SPAC31G5.08-1.

Proteomic databases

MaxQBi P87214.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC31G5.08.1 ; SPAC31G5.08.1:pep ; SPAC31G5.08 .
GeneIDi 2543161.
KEGGi spo:SPAC31G5.08.

Organism-specific databases

PomBasei SPAC31G5.08.

Phylogenomic databases

eggNOGi COG1587.
HOGENOMi HOG000216635.
InParanoidi P87214.
KOi K01719.
OMAi DKGIAME.
OrthoDBi EOG7J44HQ.
PhylomeDBi P87214.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00320 .

Miscellaneous databases

NextBioi 20804187.
PROi P87214.

Family and domain databases

InterProi IPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view ]
Pfami PF02602. HEM4. 1 hit.
[Graphical view ]
SUPFAMi SSF69618. SSF69618. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "S.pombe uroporphrinogen III synthase gene."
    Kawamukai M.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiHEM4_SCHPO
AccessioniPrimary (citable) accession number: P87214
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3