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Protein

Phosphatidylinositol N-acetylglucosaminyltransferase gpi3 subunit

Gene

gpi3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.By similarity

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiR-SPO-162710. Synthesis of glycosylphosphatidylinositol (GPI).
UniPathwayiUPA00196.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase gpi3 subunit (EC:2.4.1.198)
Alternative name(s):
GlcNAc-PI synthesis protein
Gene namesi
Name:gpi3
ORF Names:SPBC3D6.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC3D6.07.
PomBaseiSPBC3D6.07. gpi3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003391381 – 456Phosphatidylinositol N-acetylglucosaminyltransferase gpi3 subunitAdd BLAST456

Proteomic databases

MaxQBiP87172.
PRIDEiP87172.

Interactioni

Subunit structurei

Component of a Phosphatidylinositol N-acetylglucosaminyltransferase complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliP87172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000203293.
InParanoidiP87172.
KOiK03857.
OMAiREKYQLH.
OrthoDBiEOG092C2VJL.
PhylomeDBiP87172.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
IPR013234. PIGA_GPI_anchor_biosynthesis.
[Graphical view]
PfamiPF00534. Glycos_transf_1. 1 hit.
PF08288. PIGA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P87172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSDFFFPQP GGIESHIFQL SQRLIDLGHK VIVITHAYKD RVGVRYLTNG
60 70 80 90 100
LTVYYVPLHT VYRETTFPSF FSFFPIFRNI VIRENIEIVH GHGSLSFLCH
110 120 130 140 150
DAILHARTMG LKTCFTDHSL FGFADAGSIV TNKLLKFTMS DVNHVICVSH
160 170 180 190 200
TCRENTVLRA VLNPKRVSVI PNALVAENFQ PDPSKASKDF LTIVVISRLY
210 220 230 240 250
YNKGIDLLIA VIPRICAQHP KVRFVIAGDG PKSIDLEQMR EKYMLQDRVE
260 270 280 290 300
MLGSVRHDQV RDVMVRGHIY LHPSLTEAFG TVLVEAASCG LYVISTKVGG
310 320 330 340 350
VPEVLPSHMT RFARPEEDDL ADTLSSVITD YLDHKIKTET FHEEVKQMYS
360 370 380 390 400
WIDVAERTEK VYDSICSENN LRLIDRLKLY YGCGQWAGKL FCLLIAIDYL
410 420 430 440 450
VMVLLEWIWP ASDIDPAVDR VSSTFKISKQ NFDESLVLTD PKKKTKIKTA

CLKDAQ
Length:456
Mass (Da):51,778
Last modified:July 1, 1997 - v1
Checksum:i829C189D186A1919
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB09127.1.
PIRiT40367.
RefSeqiNP_595519.1. NM_001021428.1.

Genome annotation databases

EnsemblFungiiSPBC3D6.07.1; SPBC3D6.07.1:pep; SPBC3D6.07.
GeneIDi2540986.
KEGGispo:SPBC3D6.07.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB09127.1.
PIRiT40367.
RefSeqiNP_595519.1. NM_001021428.1.

3D structure databases

ProteinModelPortaliP87172.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Proteomic databases

MaxQBiP87172.
PRIDEiP87172.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC3D6.07.1; SPBC3D6.07.1:pep; SPBC3D6.07.
GeneIDi2540986.
KEGGispo:SPBC3D6.07.

Organism-specific databases

EuPathDBiFungiDB:SPBC3D6.07.
PomBaseiSPBC3D6.07. gpi3.

Phylogenomic databases

HOGENOMiHOG000203293.
InParanoidiP87172.
KOiK03857.
OMAiREKYQLH.
OrthoDBiEOG092C2VJL.
PhylomeDBiP87172.

Enzyme and pathway databases

UniPathwayiUPA00196.
ReactomeiR-SPO-162710. Synthesis of glycosylphosphatidylinositol (GPI).

Miscellaneous databases

PROiP87172.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
IPR013234. PIGA_GPI_anchor_biosynthesis.
[Graphical view]
PfamiPF00534. Glycos_transf_1. 1 hit.
PF08288. PIGA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPI3_SCHPO
AccessioniPrimary (citable) accession number: P87172
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 1, 1997
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.