Skip Header

Contribute Send feedback
Read comments (?) or add your own

P87171 (KPR4_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribose-phosphate pyrophosphokinase 4

EC=2.7.6.1
Alternative name(s):
Phosphoribosyl pyrophosphate synthase 4
Gene names
Name:prs4
ORF Names:SPBC3D6.06c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases By similarity.

Catalytic activity

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. UniProtKB P38063

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. UniProtKB P38063

Subcellular location

Cytoplasm By similarity UniProtKB P38063.

Sequence similarities

Belongs to the ribose-phosphate pyrophosphokinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 341341Ribose-phosphate pyrophosphokinase 4
PRO_0000309464

Sites

Metal binding1521Magnesium Potential UniProtKB P38063
Metal binding1541Magnesium Potential UniProtKB P38063
Metal binding1671Magnesium Potential UniProtKB P38063

Sequences

Sequence LengthMass (Da)Tools
P87171 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 3D7348E9AA0F9DC7

FASTA34137,338
        10         20         30         40         50         60 
MKNLVVFGTE SHPKLTESIC EHLCLDIGRV ELSKFSNGET SVRIKQSVRG CDVYIVSPAS 

        70         80         90        100        110        120 
GQVNDHLMEL LIMISACKTA SAKKVTAVLP VFPYSRQPDQ KFSFSGAPLS DLQDAVVPCK 

       130        140        150        160        170        180 
KQTGYHPWIA QSGTLVADLL MCSGADHIIT MDLHDPQFQG FFDIPVDNLF GRPLLKHYIS 

       190        200        210        220        230        240 
LNIPNYHNAV IVSPDAGGAK RATAIADALG LDFALIHKNR RHEYGTSLML VGDVQNKVAI 

       250        260        270        280        290        300 
LIDDLIDTAY TLVRAAEFVK EHGASKIYAL VTHCVLSGDA IERVKLSCID KLIVTNTAPQ 

       310        320        330        340 
TITPSGCFDI IDVAPTFAEA IRRIHNGESI SILYDHNQVW V 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329671 Genomic DNA. Translation: CAB09126.1.
PIRT40366.
RefSeqNP_595518.1. NM_001021427.1.

3D structure databases

HSSPHSSP built from PDB template 1DKU based on UniProtKB P14193.
ProteinModelPortalP87171.
ModBaseSearch...

Protein-protein interaction databases

STRINGP87171.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC3D6.06c.1; SPBC3D6.06c.1:pep; SPBC3D6.06c.
GeneID2541014.
GenomeReviewsGene locus prs4 in contig CU329671_GR.
KEGGspo:SPBC3D6.06c.
NMPDRfig|4896.1.peg.1384.

Organism-specific databases

GeneDB_SpombeSPBC3D6.06c.

Phylogenomic databases

eggNOGfuNOG07610.
GeneTreeEFGT00050000003657.
HOGENOMHBG519284.
OMACIMISAC.
OrthoDBEOG4CG3HW.

Gene expression databases

ArrayExpressP87171.

Family and domain databases

InterProIPR000842. PRib_PP_synth_CS.
IPR000836. PRibTrfase.
IPR005946. Rib-P_diPkinase.
[Graphical view]
KOK00948.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01251. RibP_PPkin. 1 hit.
PROSITEPS00114. PRPP_SYNTHASE. 1 hit.
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPR4_SCHPO
AccessionPrimary (citable) accession number: P87171
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 1, 1997
Last modified: December 14, 2011
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families