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Protein

Translation initiation factor eIF-2B subunit epsilon

Gene

GCD6

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Subunit of the guanine nucleotide exchange factor for eIF-2.By similarity

GO - Molecular functioni

  1. nucleotidyltransferase activity Source: InterPro
  2. translation initiation factor activity Source: CGD

GO - Biological processi

  1. translational initiation Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit epsilon
Alternative name(s):
GCD complex subunit GCD6
Guanine nucleotide exchange factor subunit GCD6
eIF-2B GDP-GTP exchange factor subunit epsilon
Gene namesi
Name:GCD6
Synonyms:TIF225
ORF Names:CaO19.407, CaO19.8037
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005543. GCD6.

Subcellular locationi

GO - Cellular componenti

  1. eukaryotic translation initiation factor 2B complex Source: CGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 732732Translation initiation factor eIF-2B subunit epsilonPRO_0000156076Add
BLAST

Interactioni

Subunit structurei

Complex of five different subunits; alpha (GCN3), beta (GCD7), gamma (GCD1), delta (GCD2) and epsilon (GCD6).By similarity

Protein-protein interaction databases

STRINGi5476.CAL0005543.

Structurei

3D structure databases

ProteinModelPortaliP87163.
SMRiP87163. Positions 564-720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini559 – 726168W2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 W2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1208.
InParanoidiP87163.
KOiK03240.
OrthoDBiEOG7NSBB4.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
3.90.550.10. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR001451. Hexapep_transf.
IPR016021. MIF4-like_typ_1/2/3.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
IPR011004. Trimer_LpxA-like.
IPR003307. W2_domain.
[Graphical view]
PfamiPF00132. Hexapep. 2 hits.
PF00483. NTP_transferase. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF51161. SSF51161. 1 hit.
SSF53448. SSF53448. 2 hits.
PROSITEiPS51363. W2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P87163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKSKKQAA TQSKSKKSKD LVDERFQAIV LTDSFETRFM PLTAVHPRCL
60 70 80 90 100
LPLANVPLIE YTLEFLANAG VNEVYLMCSA HADQIQEYIE NSKWMGDNSP
110 120 130 140 150
FSVTTIMSIE SRSVGDTMRD LDNRGLIAGD FLLVSGDVVT NMDFSKALQF
160 170 180 190 200
HKQKKAQDKD HIATMVLNQA SPLHRTRSQI DPAAFVLDKE TNRCIFYQSI
210 220 230 240 250
PPVSGKKTCI SIDPELLEDF QGELQVRNDL IDCHVDICSP HVPQIFQENF
260 270 280 290 300
DYQYLRSDFL KGVLTSDLLK KTIYAYISKD SSEYAARVES WSTYDAISQD
310 320 330 340 350
ILARWCYPLV PDSNLVEGNS YSYELNNIYK EDKIILAQSC KIGTSTSIGR
360 370 380 390 400
NSSVGEGTQI KNSVIGRNCT IGKNVVIENS YIWDNAVIKD NSVLNRSIVA
410 420 430 440 450
ADAQIGNNVT LSPGSVIGFN VIIGDDKVIP HNVKIVETPI VTENEFGDFD
460 470 480 490 500
DESNSEDENE YEDGNAVPVL AVKDVELVGE TGKGFAYESE IESGDEDDEE
510 520 530 540 550
FVGNGTYSGI IYQMNSLNVS DDSIASVSNK KVKKHSHRRR LSMNSMISDN
560 570 580 590 600
GGAFESDEGE EEEDFGVEGL ATVTRAIENN HDIDTALLEL NTLRMSMNVT
610 620 630 640 650
YHDVRSVTTQ ALVNKIVDFI TTGTLTPQEA ATKIFTKWGI MFKRQVFSPE
660 670 680 690 700
EEVDLLNIVE EKSSVLDKAY NQIVLFLGVK SFYDMEVVEE ENILKWWNDG
710 720 730
ENDEVRTLAA KFITWLQEAD EEDSDEDDED SE
Length:732
Mass (Da):81,937
Last modified:May 5, 2009 - v2
Checksum:i91B7CA21D62324BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69674 Genomic DNA. Translation: AAC49714.1.
AACQ01000177 Genomic DNA. Translation: EAK92687.1.
AACQ01000176 Genomic DNA. Translation: EAK92716.1.
RefSeqiXP_711895.1. XM_706802.1.
XP_711924.1. XM_706831.1.

Genome annotation databases

GeneIDi3646459.
3646510.
KEGGical:CaO19.407.
cal:CaO19.8037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69674 Genomic DNA. Translation: AAC49714.1.
AACQ01000177 Genomic DNA. Translation: EAK92687.1.
AACQ01000176 Genomic DNA. Translation: EAK92716.1.
RefSeqiXP_711895.1. XM_706802.1.
XP_711924.1. XM_706831.1.

3D structure databases

ProteinModelPortaliP87163.
SMRiP87163. Positions 564-720.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0005543.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3646459.
3646510.
KEGGical:CaO19.407.
cal:CaO19.8037.

Organism-specific databases

CGDiCAL0005543. GCD6.

Phylogenomic databases

eggNOGiCOG1208.
InParanoidiP87163.
KOiK03240.
OrthoDBiEOG7NSBB4.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
3.90.550.10. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR001451. Hexapep_transf.
IPR016021. MIF4-like_typ_1/2/3.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
IPR011004. Trimer_LpxA-like.
IPR003307. W2_domain.
[Graphical view]
PfamiPF00132. Hexapep. 2 hits.
PF00483. NTP_transferase. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF51161. SSF51161. 1 hit.
SSF53448. SSF53448. 2 hits.
PROSITEiPS51363. W2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "Cloning and expression of squalene epoxidase from the pathogenic yeast Candida albicans."
    Favre B., Ryder N.S.
    Gene 189:119-126(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 544-732.
    Strain: SFI-0124.

Entry informationi

Entry nameiEI2BE_CANAL
AccessioniPrimary (citable) accession number: P87163
Secondary accession number(s): Q59QB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 5, 2009
Last modified: January 7, 2015
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.