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P87163

- EI2BE_CANAL

UniProt

P87163 - EI2BE_CANAL

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Protein

Translation initiation factor eIF-2B subunit epsilon

Gene
GCD6, TIF225, CaO19.407, CaO19.8037
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Subunit of the guanine nucleotide exchange factor for eIF-2 By similarity.

GO - Molecular functioni

  1. nucleotidyltransferase activity Source: InterPro
  2. translation initiation factor activity Source: CGD

GO - Biological processi

  1. translational initiation Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit epsilon
Alternative name(s):
GCD complex subunit GCD6
Guanine nucleotide exchange factor subunit GCD6
eIF-2B GDP-GTP exchange factor subunit epsilon
Gene namesi
Name:GCD6
Synonyms:TIF225
ORF Names:CaO19.407, CaO19.8037
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0005543. GCD6.

Subcellular locationi

GO - Cellular componenti

  1. eukaryotic translation initiation factor 2B complex Source: CGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 732732Translation initiation factor eIF-2B subunit epsilonPRO_0000156076Add
BLAST

Interactioni

Subunit structurei

Complex of five different subunits; alpha (GCN3), beta (GCD7), gamma (GCD1), delta (GCD2) and epsilon (GCD6) By similarity.

Protein-protein interaction databases

STRINGi5476.CAL0005543.

Structurei

3D structure databases

ProteinModelPortaliP87163.
SMRiP87163. Positions 564-720.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini559 – 726168W2Add
BLAST

Sequence similaritiesi

Contains 1 W2 domain.

Phylogenomic databases

eggNOGiCOG1208.
KOiK03240.
OrthoDBiEOG7NSBB4.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
3.90.550.10. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR001451. Hexapep_transf.
IPR016021. MIF4-like_typ_1/2/3.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
IPR011004. Trimer_LpxA-like.
IPR003307. W2_domain.
[Graphical view]
PfamiPF00132. Hexapep. 2 hits.
PF00483. NTP_transferase. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF51161. SSF51161. 1 hit.
SSF53448. SSF53448. 2 hits.
PROSITEiPS51363. W2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P87163-1 [UniParc]FASTAAdd to Basket

« Hide

MAPKSKKQAA TQSKSKKSKD LVDERFQAIV LTDSFETRFM PLTAVHPRCL    50
LPLANVPLIE YTLEFLANAG VNEVYLMCSA HADQIQEYIE NSKWMGDNSP 100
FSVTTIMSIE SRSVGDTMRD LDNRGLIAGD FLLVSGDVVT NMDFSKALQF 150
HKQKKAQDKD HIATMVLNQA SPLHRTRSQI DPAAFVLDKE TNRCIFYQSI 200
PPVSGKKTCI SIDPELLEDF QGELQVRNDL IDCHVDICSP HVPQIFQENF 250
DYQYLRSDFL KGVLTSDLLK KTIYAYISKD SSEYAARVES WSTYDAISQD 300
ILARWCYPLV PDSNLVEGNS YSYELNNIYK EDKIILAQSC KIGTSTSIGR 350
NSSVGEGTQI KNSVIGRNCT IGKNVVIENS YIWDNAVIKD NSVLNRSIVA 400
ADAQIGNNVT LSPGSVIGFN VIIGDDKVIP HNVKIVETPI VTENEFGDFD 450
DESNSEDENE YEDGNAVPVL AVKDVELVGE TGKGFAYESE IESGDEDDEE 500
FVGNGTYSGI IYQMNSLNVS DDSIASVSNK KVKKHSHRRR LSMNSMISDN 550
GGAFESDEGE EEEDFGVEGL ATVTRAIENN HDIDTALLEL NTLRMSMNVT 600
YHDVRSVTTQ ALVNKIVDFI TTGTLTPQEA ATKIFTKWGI MFKRQVFSPE 650
EEVDLLNIVE EKSSVLDKAY NQIVLFLGVK SFYDMEVVEE ENILKWWNDG 700
ENDEVRTLAA KFITWLQEAD EEDSDEDDED SE 732
Length:732
Mass (Da):81,937
Last modified:May 5, 2009 - v2
Checksum:i91B7CA21D62324BE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U69674 Genomic DNA. Translation: AAC49714.1.
AACQ01000177 Genomic DNA. Translation: EAK92687.1.
AACQ01000176 Genomic DNA. Translation: EAK92716.1.
RefSeqiXP_711895.1. XM_706802.1.
XP_711924.1. XM_706831.1.

Genome annotation databases

GeneIDi3646459.
3646510.
KEGGical:CaO19.407.
cal:CaO19.8037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U69674 Genomic DNA. Translation: AAC49714.1 .
AACQ01000177 Genomic DNA. Translation: EAK92687.1 .
AACQ01000176 Genomic DNA. Translation: EAK92716.1 .
RefSeqi XP_711895.1. XM_706802.1.
XP_711924.1. XM_706831.1.

3D structure databases

ProteinModelPortali P87163.
SMRi P87163. Positions 564-720.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0005543.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3646459.
3646510.
KEGGi cal:CaO19.407.
cal:CaO19.8037.

Organism-specific databases

CGDi CAL0005543. GCD6.

Phylogenomic databases

eggNOGi COG1208.
KOi K03240.
OrthoDBi EOG7NSBB4.

Family and domain databases

Gene3Di 1.25.40.180. 1 hit.
3.90.550.10. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR001451. Hexapep_transf.
IPR016021. MIF4-like_typ_1/2/3.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
IPR011004. Trimer_LpxA-like.
IPR003307. W2_domain.
[Graphical view ]
Pfami PF00132. Hexapep. 2 hits.
PF00483. NTP_transferase. 1 hit.
PF02020. W2. 1 hit.
[Graphical view ]
SMARTi SM00515. eIF5C. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF51161. SSF51161. 1 hit.
SSF53448. SSF53448. 2 hits.
PROSITEi PS51363. W2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "Cloning and expression of squalene epoxidase from the pathogenic yeast Candida albicans."
    Favre B., Ryder N.S.
    Gene 189:119-126(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 544-732.
    Strain: SFI-0124.

Entry informationi

Entry nameiEI2BE_CANAL
AccessioniPrimary (citable) accession number: P87163
Secondary accession number(s): Q59QB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 5, 2009
Last modified: June 11, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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