P87163 (EI2BE_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Translation initiation factor eIF-2B subunit epsilon

Alternative name(s):
GCD complex subunit GCD6
Guanine nucleotide exchange factor subunit GCD6
eIF-2B GDP-GTP exchange factor subunit epsilon

Gene names

Name:	GCD6
Synonyms:	TIF225
ORF Names:	CaO19.407, CaO19.8037

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	732 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunit of the guanine nucleotide exchange factor for eIF-2 By similarity.
Subunit structure	Complex of five different subunits; alpha (GCN3), beta (GCD7), gamma (GCD1), delta (GCD2) and epsilon (GCD6) By similarity.
Sequence similarities	Belongs to the eIF-2B gamma/epsilon subunits family. Contains 1 W2 domain.

Ontologies

Keywords
Biological process	Protein biosynthesis
Molecular function	Initiation factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	eukaryotic translation initiation factor 2B complex Inferred from sequence or structural similarity Ref.2. Source: CGD
Molecular_function	nucleotidyltransferase activity Inferred from electronic annotation. Source: InterPro translation initiation factor activity Inferred from sequence or structural similarity Ref.2. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 732	732	Translation initiation factor eIF-2B subunit epsilon		PRO_0000156076
Regions
	Domain	559 – 726	168	W2

Sequences

	Sequence		Length	Mass (Da)
	P87163 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: 91B7CA21D62324BE	FASTA	732	81,937
	10 20 30 40 50 60 MAPKSKKQAA TQSKSKKSKD LVDERFQAIV LTDSFETRFM PLTAVHPRCL LPLANVPLIE 70 80 90 100 110 120 YTLEFLANAG VNEVYLMCSA HADQIQEYIE NSKWMGDNSP FSVTTIMSIE SRSVGDTMRD 130 140 150 160 170 180 LDNRGLIAGD FLLVSGDVVT NMDFSKALQF HKQKKAQDKD HIATMVLNQA SPLHRTRSQI 190 200 210 220 230 240 DPAAFVLDKE TNRCIFYQSI PPVSGKKTCI SIDPELLEDF QGELQVRNDL IDCHVDICSP 250 260 270 280 290 300 HVPQIFQENF DYQYLRSDFL KGVLTSDLLK KTIYAYISKD SSEYAARVES WSTYDAISQD 310 320 330 340 350 360 ILARWCYPLV PDSNLVEGNS YSYELNNIYK EDKIILAQSC KIGTSTSIGR NSSVGEGTQI 370 380 390 400 410 420 KNSVIGRNCT IGKNVVIENS YIWDNAVIKD NSVLNRSIVA ADAQIGNNVT LSPGSVIGFN 430 440 450 460 470 480 VIIGDDKVIP HNVKIVETPI VTENEFGDFD DESNSEDENE YEDGNAVPVL AVKDVELVGE 490 500 510 520 530 540 TGKGFAYESE IESGDEDDEE FVGNGTYSGI IYQMNSLNVS DDSIASVSNK KVKKHSHRRR 550 560 570 580 590 600 LSMNSMISDN GGAFESDEGE EEEDFGVEGL ATVTRAIENN HDIDTALLEL NTLRMSMNVT 610 620 630 640 650 660 YHDVRSVTTQ ALVNKIVDFI TTGTLTPQEA ATKIFTKWGI MFKRQVFSPE EEVDLLNIVE 670 680 690 700 710 720 EKSSVLDKAY NQIVLFLGVK SFYDMEVVEE ENILKWWNDG ENDEVRTLAA KFITWLQEAD 730 EEDSDEDDED SE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.
[2]	"Cloning and expression of squalene epoxidase from the pathogenic yeast Candida albicans." Favre B., Ryder N.S. Gene 189:119-126(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 544-732. Strain: SFI-0124.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U69674 Genomic DNA. Translation: AAC49714.1. AACQ01000177 Genomic DNA. Translation: EAK92687.1. AACQ01000176 Genomic DNA. Translation: EAK92716.1.
RefSeq	XP_711895.1. XM_706802.1. XP_711924.1. XM_706831.1.
3D structure databases
ProteinModelPortal	P87163.
SMR	P87163. Positions 564-720.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0005543.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3646459. 3646510.
KEGG	cal:CaO19.407. cal:CaO19.8037.
Organism-specific databases
CGD	CAL0005543. GCD6.
Phylogenomic databases
eggNOG	COG1208.
KO	K03240.
Family and domain databases
Gene3D	1.25.40.180. 1 hit.
InterPro	IPR016024. ARM-type_fold. IPR001451. Hexapep_transf. IPR016021. MIF4-like_typ_1/2/3. IPR005835. NTP_transferase. IPR011004. Trimer_LpxA-like. IPR003307. W2_domain. [Graphical view]
Pfam	PF00132. Hexapep. 3 hits. PF00483. NTP_transferase. 1 hit. PF02020. W2. 1 hit. [Graphical view]
SMART	SM00515. eIF5C. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF51161. Trimer_LpxA_like. 1 hit.
PROSITE	PS51363. W2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EI2BE_CANAL

Accession

Primary (citable) accession number: P87163
Secondary accession number(s): Q59QB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 5, 2009
Last modified:	April 3, 2013
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program