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P87163

- EI2BE_CANAL

UniProt

P87163 - EI2BE_CANAL

Protein

Translation initiation factor eIF-2B subunit epsilon

Gene

GCD6

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    Subunit of the guanine nucleotide exchange factor for eIF-2.By similarity

    GO - Molecular functioni

    1. nucleotidyltransferase activity Source: InterPro
    2. translation initiation factor activity Source: CGD

    GO - Biological processi

    1. translational initiation Source: CGD

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor eIF-2B subunit epsilon
    Alternative name(s):
    GCD complex subunit GCD6
    Guanine nucleotide exchange factor subunit GCD6
    eIF-2B GDP-GTP exchange factor subunit epsilon
    Gene namesi
    Name:GCD6
    Synonyms:TIF225
    ORF Names:CaO19.407, CaO19.8037
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0005543. GCD6.

    Subcellular locationi

    GO - Cellular componenti

    1. eukaryotic translation initiation factor 2B complex Source: CGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 732732Translation initiation factor eIF-2B subunit epsilonPRO_0000156076Add
    BLAST

    Interactioni

    Subunit structurei

    Complex of five different subunits; alpha (GCN3), beta (GCD7), gamma (GCD1), delta (GCD2) and epsilon (GCD6).By similarity

    Protein-protein interaction databases

    STRINGi5476.CAL0005543.

    Structurei

    3D structure databases

    ProteinModelPortaliP87163.
    SMRiP87163. Positions 564-720.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini559 – 726168W2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 W2 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1208.
    KOiK03240.
    OrthoDBiEOG7NSBB4.

    Family and domain databases

    Gene3Di1.25.40.180. 1 hit.
    3.90.550.10. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR001451. Hexapep_transf.
    IPR016021. MIF4-like_typ_1/2/3.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR011004. Trimer_LpxA-like.
    IPR003307. W2_domain.
    [Graphical view]
    PfamiPF00132. Hexapep. 2 hits.
    PF00483. NTP_transferase. 1 hit.
    PF02020. W2. 1 hit.
    [Graphical view]
    SMARTiSM00515. eIF5C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF51161. SSF51161. 1 hit.
    SSF53448. SSF53448. 2 hits.
    PROSITEiPS51363. W2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P87163-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPKSKKQAA TQSKSKKSKD LVDERFQAIV LTDSFETRFM PLTAVHPRCL    50
    LPLANVPLIE YTLEFLANAG VNEVYLMCSA HADQIQEYIE NSKWMGDNSP 100
    FSVTTIMSIE SRSVGDTMRD LDNRGLIAGD FLLVSGDVVT NMDFSKALQF 150
    HKQKKAQDKD HIATMVLNQA SPLHRTRSQI DPAAFVLDKE TNRCIFYQSI 200
    PPVSGKKTCI SIDPELLEDF QGELQVRNDL IDCHVDICSP HVPQIFQENF 250
    DYQYLRSDFL KGVLTSDLLK KTIYAYISKD SSEYAARVES WSTYDAISQD 300
    ILARWCYPLV PDSNLVEGNS YSYELNNIYK EDKIILAQSC KIGTSTSIGR 350
    NSSVGEGTQI KNSVIGRNCT IGKNVVIENS YIWDNAVIKD NSVLNRSIVA 400
    ADAQIGNNVT LSPGSVIGFN VIIGDDKVIP HNVKIVETPI VTENEFGDFD 450
    DESNSEDENE YEDGNAVPVL AVKDVELVGE TGKGFAYESE IESGDEDDEE 500
    FVGNGTYSGI IYQMNSLNVS DDSIASVSNK KVKKHSHRRR LSMNSMISDN 550
    GGAFESDEGE EEEDFGVEGL ATVTRAIENN HDIDTALLEL NTLRMSMNVT 600
    YHDVRSVTTQ ALVNKIVDFI TTGTLTPQEA ATKIFTKWGI MFKRQVFSPE 650
    EEVDLLNIVE EKSSVLDKAY NQIVLFLGVK SFYDMEVVEE ENILKWWNDG 700
    ENDEVRTLAA KFITWLQEAD EEDSDEDDED SE 732
    Length:732
    Mass (Da):81,937
    Last modified:May 5, 2009 - v2
    Checksum:i91B7CA21D62324BE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U69674 Genomic DNA. Translation: AAC49714.1.
    AACQ01000177 Genomic DNA. Translation: EAK92687.1.
    AACQ01000176 Genomic DNA. Translation: EAK92716.1.
    RefSeqiXP_711895.1. XM_706802.1.
    XP_711924.1. XM_706831.1.

    Genome annotation databases

    GeneIDi3646459.
    3646510.
    KEGGical:CaO19.407.
    cal:CaO19.8037.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U69674 Genomic DNA. Translation: AAC49714.1 .
    AACQ01000177 Genomic DNA. Translation: EAK92687.1 .
    AACQ01000176 Genomic DNA. Translation: EAK92716.1 .
    RefSeqi XP_711895.1. XM_706802.1.
    XP_711924.1. XM_706831.1.

    3D structure databases

    ProteinModelPortali P87163.
    SMRi P87163. Positions 564-720.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0005543.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3646459.
    3646510.
    KEGGi cal:CaO19.407.
    cal:CaO19.8037.

    Organism-specific databases

    CGDi CAL0005543. GCD6.

    Phylogenomic databases

    eggNOGi COG1208.
    KOi K03240.
    OrthoDBi EOG7NSBB4.

    Family and domain databases

    Gene3Di 1.25.40.180. 1 hit.
    3.90.550.10. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR001451. Hexapep_transf.
    IPR016021. MIF4-like_typ_1/2/3.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR011004. Trimer_LpxA-like.
    IPR003307. W2_domain.
    [Graphical view ]
    Pfami PF00132. Hexapep. 2 hits.
    PF00483. NTP_transferase. 1 hit.
    PF02020. W2. 1 hit.
    [Graphical view ]
    SMARTi SM00515. eIF5C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF51161. SSF51161. 1 hit.
    SSF53448. SSF53448. 2 hits.
    PROSITEi PS51363. W2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. "Cloning and expression of squalene epoxidase from the pathogenic yeast Candida albicans."
      Favre B., Ryder N.S.
      Gene 189:119-126(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 544-732.
      Strain: SFI-0124.

    Entry informationi

    Entry nameiEI2BE_CANAL
    AccessioniPrimary (citable) accession number: P87163
    Secondary accession number(s): Q59QB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3