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P87163 (EI2BE_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor eIF-2B subunit epsilon
Alternative name(s):
GCD complex subunit GCD6
Guanine nucleotide exchange factor subunit GCD6
eIF-2B GDP-GTP exchange factor subunit epsilon
Gene names
Name:GCD6
Synonyms:TIF225
ORF Names:CaO19.407, CaO19.8037
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length732 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunit of the guanine nucleotide exchange factor for eIF-2 By similarity.

Subunit structure

Complex of five different subunits; alpha (GCN3), beta (GCD7), gamma (GCD1), delta (GCD2) and epsilon (GCD6) By similarity.

Sequence similarities

Belongs to the eIF-2B gamma/epsilon subunits family.

Contains 1 W2 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 732732Translation initiation factor eIF-2B subunit epsilon
PRO_0000156076

Regions

Domain559 – 726168W2

Sequences

Sequence LengthMass (Da)Tools
P87163 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 91B7CA21D62324BE

FASTA73281,937
        10         20         30         40         50         60 
MAPKSKKQAA TQSKSKKSKD LVDERFQAIV LTDSFETRFM PLTAVHPRCL LPLANVPLIE 

        70         80         90        100        110        120 
YTLEFLANAG VNEVYLMCSA HADQIQEYIE NSKWMGDNSP FSVTTIMSIE SRSVGDTMRD 

       130        140        150        160        170        180 
LDNRGLIAGD FLLVSGDVVT NMDFSKALQF HKQKKAQDKD HIATMVLNQA SPLHRTRSQI 

       190        200        210        220        230        240 
DPAAFVLDKE TNRCIFYQSI PPVSGKKTCI SIDPELLEDF QGELQVRNDL IDCHVDICSP 

       250        260        270        280        290        300 
HVPQIFQENF DYQYLRSDFL KGVLTSDLLK KTIYAYISKD SSEYAARVES WSTYDAISQD 

       310        320        330        340        350        360 
ILARWCYPLV PDSNLVEGNS YSYELNNIYK EDKIILAQSC KIGTSTSIGR NSSVGEGTQI 

       370        380        390        400        410        420 
KNSVIGRNCT IGKNVVIENS YIWDNAVIKD NSVLNRSIVA ADAQIGNNVT LSPGSVIGFN 

       430        440        450        460        470        480 
VIIGDDKVIP HNVKIVETPI VTENEFGDFD DESNSEDENE YEDGNAVPVL AVKDVELVGE 

       490        500        510        520        530        540 
TGKGFAYESE IESGDEDDEE FVGNGTYSGI IYQMNSLNVS DDSIASVSNK KVKKHSHRRR 

       550        560        570        580        590        600 
LSMNSMISDN GGAFESDEGE EEEDFGVEGL ATVTRAIENN HDIDTALLEL NTLRMSMNVT 

       610        620        630        640        650        660 
YHDVRSVTTQ ALVNKIVDFI TTGTLTPQEA ATKIFTKWGI MFKRQVFSPE EEVDLLNIVE 

       670        680        690        700        710        720 
EKSSVLDKAY NQIVLFLGVK SFYDMEVVEE ENILKWWNDG ENDEVRTLAA KFITWLQEAD 

       730 
EEDSDEDDED SE 

« Hide

References

« Hide 'large scale' references
[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"Cloning and expression of squalene epoxidase from the pathogenic yeast Candida albicans."
Favre B., Ryder N.S.
Gene 189:119-126(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 544-732.
Strain: SFI-0124.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U69674 Genomic DNA. Translation: AAC49714.1.
AACQ01000177 Genomic DNA. Translation: EAK92687.1.
AACQ01000176 Genomic DNA. Translation: EAK92716.1.
RefSeqXP_711895.1. XM_706802.1.
XP_711924.1. XM_706831.1.

3D structure databases

ProteinModelPortalP87163.
SMRP87163. Positions 564-720.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0005543.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3646459.
3646510.
KEGGcal:CaO19.407.
cal:CaO19.8037.

Organism-specific databases

CGDCAL0005543. GCD6.

Phylogenomic databases

eggNOGCOG1208.
KOK03240.
OrthoDBEOG7NSBB4.

Family and domain databases

Gene3D1.25.40.180. 1 hit.
3.90.550.10. 1 hit.
InterProIPR016024. ARM-type_fold.
IPR001451. Hexapep_transf.
IPR016021. MIF4-like_typ_1/2/3.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
IPR011004. Trimer_LpxA-like.
IPR003307. W2_domain.
[Graphical view]
PfamPF00132. Hexapep. 2 hits.
PF00483. NTP_transferase. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTSM00515. eIF5C. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
SSF51161. SSF51161. 1 hit.
SSF53448. SSF53448. 2 hits.
PROSITEPS51363. W2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEI2BE_CANAL
AccessionPrimary (citable) accession number: P87163
Secondary accession number(s): Q59QB1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 5, 2009
Last modified: June 11, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names