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Protein

Probable T-complex protein 1 subunit eta

Gene

cct7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable T-complex protein 1 subunit eta
Short name:
TCP-1-eta
Alternative name(s):
CCT-eta
Gene namesi
Name:cct7
ORF Names:SPBC25H2.12c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC25H2.12c
PomBaseiSPBC25H2.12c cct7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283711 – 558Probable T-complex protein 1 subunit etaAdd BLAST558

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei176Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP87153
PaxDbiP87153
PRIDEiP87153

PTM databases

iPTMnetiP87153

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi277099, 1 interactor
IntActiP87153, 1 interactor
STRINGi4896.SPBC25H2.12c.1

Structurei

3D structure databases

ProteinModelPortaliP87153
SMRiP87153
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

HOGENOMiHOG000226730
InParanoidiP87153
KOiK09499
OMAiQGCPNAK
OrthoDBiEOG092C1WYZ
PhylomeDBiP87153

Family and domain databases

CDDicd03340 TCP1_eta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012720 Chap_CCT_eta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353:SF22 PTHR11353:SF22, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02345 chap_CCT_eta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

P87153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLGGPQIPV IVLKEGTDDS QGRGQLLSNI NACVAVQDTI RTTLGPLGAD
60 70 80 90 100
KLMVDDRGEV VISNDGATIM KLLDIVHPAA KTLVDIARAQ DAEVGDGTTS
110 120 130 140 150
VVVFAGELLR EARTFVEDGV SSHLIIRGYR KAAQLAVNKI KEIAIHLDLS
160 170 180 190 200
DEGKLRDLLT KCASTAMNSK LIRSNSTFFT KMVVDAVLTL DQEDLNENMI
210 220 230 240 250
GIKKVPGGAM EDSLLVKGVA FKKTFSYAGF EQQPKFFKNP KILCLDVELE
260 270 280 290 300
LKAEKDNAEV RVDKVQEYQN IVDAEWRIIF SKLEAIVATG AKVVLSKLPI
310 320 330 340 350
GDLATQYFAD RDIFCAGRVA ADDLNRVVQA VGGSIQSTCS NIEEKHLGTC
360 370 380 390 400
DTFEERQIGG DRFNLFEGCP KAKTCTLILR GGADQFIAEV ERSLHDAIMI
410 420 430 440 450
VKHALKNNLV VAGGGACEME LSKYLRDYSL TISGKQQNFI AAFARSLEVI
460 470 480 490 500
PRQLCDNAGF DSTNILNKLR MQHAKGEMWA GVDMDSEGVA NNFEKFVWEP
510 520 530 540 550
STVKSNAILS ATEAATLILS VDETIKNEPS QQPQAPQGAL PPGAANRIMR

GRGRGMPR
Length:558
Mass (Da):60,687
Last modified:July 1, 1997 - v1
Checksum:iC4C1F843F44C5253
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB08778.1
PIRiT40007
RefSeqiNP_596355.1, NM_001022275.2

Genome annotation databases

EnsemblFungiiSPBC25H2.12c.1; SPBC25H2.12c.1:pep; SPBC25H2.12c
GeneIDi2540572
KEGGispo:SPBC25H2.12c

Similar proteinsi

Entry informationi

Entry nameiTCPH_SCHPO
AccessioniPrimary (citable) accession number: P87153
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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