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Protein

Transcriptional activator spt7

Gene

spt7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator spt7
Gene namesi
Name:spt7
ORF Names:SPBC25H2.11c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC25H2.11c.
PomBaseiSPBC25H2.11c. spt7.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: PomBase
  • SAGA complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003103281 – 992Transcriptional activator spt7Add BLAST992

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei475Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP87152.
PRIDEiP87152.

PTM databases

iPTMnetiP87152.

Interactioni

Subunit structurei

Component of the SAGA, SALSA and SLIK complexes.By similarity

Protein-protein interaction databases

BioGridi276936. 21 interactors.
IntActiP87152. 2 interactors.
MINTiMINT-8210492.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini329 – 399BromoPROSITE-ProRule annotationAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi128 – 131Poly-Glu4
Compositional biasi149 – 154Poly-Asp6

Sequence similaritiesi

Contains 1 bromo domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain

Phylogenomic databases

InParanoidiP87152.
KOiK11359.
OMAiDDEPIMS.
OrthoDBiEOG092C1TLO.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR006565. BTP.
[Graphical view]
PfamiPF07524. Bromo_TP. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM00576. BTP. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P87152-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METNFEDSKS LDEPVLHDIA IALLKNDYWS LYLSPEQKRK YISILNDTLL
60 70 80 90 100
WNRFINVIEW DKLCDEKDSN GSNDDEEDDL DITTLFRCRC MIFDAKINPA
110 120 130 140 150
LFDLSSTSSG SIEHVDHQNI SLEASLAEEE ERKKGDAKKS EATGRQLFDD
160 170 180 190 200
DDFDESDAED SSKATITLDL QKDKSLRKSI IDLKSVDIDD MDTSGFAAIE
210 220 230 240 250
SNKALSNISF NYVYYTLEND SENINEVKKF EDEEDTSTPN TSSFQNNSSS
260 270 280 290 300
LDLSDNLSLN SKFGSLTSSF KYLLQYLEGN RSKINATDAD VKQLLSDVKK
310 320 330 340 350
NKSKWANDQR IGQEELYEAA EKVVLELRSY TEHSLAFLTK VSKRDAPDYY
360 370 380 390 400
TVIKEPMDLG TILRNLKNLH YNSKKEFVHD LMLIWSNCFL YNSHPDHPLR
410 420 430 440 450
VHAQFMKDKS LELINLIPDI VIQSRKDYDD SLIEAELESD EESTAETSKH
460 470 480 490 500
VTSKKTSSRG GQTQQAVEVH TDANSPEENN TPVTKKEVET SKPPAVSGST
510 520 530 540 550
PPVNEAAVIE SSNTLEKEPL SDVATEYWKI KTKDIRESHI LNNRRILKSL
560 570 580 590 600
QFIETELPMI RKPTAMSAFI DREVAYGSID CLPMDKGDFE PIMKLDTTPL
610 620 630 640 650
LEYDVGSGVP MTAGSVLETE SEEDLYFRDY SLFEINRNTP GVPSLMYKNI
660 670 680 690 700
AKMQEIRKLC NKIQTVRQLQ LPQPFYYEHH KSHVPFANNE PILLDIPQNY
710 720 730 740 750
DNMSSFKPLA HDVLKKLCTI ILFHAGFESF QMGALDALTE IAADYMAKMG
760 770 780 790 800
AVMDQYLIYG KDKSQQEIVG QTLGELGVDD VNDLISYVYH DVERQSVKLL
810 820 830 840 850
EIHQRLQRHF VELLRPALSE RNDEEAIFNQ NGESFVTGNF SYETGDDFFG
860 870 880 890 900
LRELGLDREL GLDSLSVPLH LLQSRLRSNM SWQPEATIKG DQEYAPPPKY
910 920 930 940 950
PPITAESISN EIGLIQGFLK KNLEEFGLDE LLEDEDIRPR SKPPRPRLPP
960 970 980 990
NGKITTGRKR IASSVFLNQS LRKKRCLKEN EQGTEVTTLP EE
Length:992
Mass (Da):112,901
Last modified:April 18, 2012 - v2
Checksum:i461B9F7A1848CBC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB08777.2.
PIRiT40006.
RefSeqiNP_596356.2. NM_001022276.2.

Genome annotation databases

EnsemblFungiiSPBC25H2.11c.1; SPBC25H2.11c.1:pep; SPBC25H2.11c.
GeneIDi2540408.
KEGGispo:SPBC25H2.11c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB08777.2.
PIRiT40006.
RefSeqiNP_596356.2. NM_001022276.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276936. 21 interactors.
IntActiP87152. 2 interactors.
MINTiMINT-8210492.

PTM databases

iPTMnetiP87152.

Proteomic databases

MaxQBiP87152.
PRIDEiP87152.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC25H2.11c.1; SPBC25H2.11c.1:pep; SPBC25H2.11c.
GeneIDi2540408.
KEGGispo:SPBC25H2.11c.

Organism-specific databases

EuPathDBiFungiDB:SPBC25H2.11c.
PomBaseiSPBC25H2.11c. spt7.

Phylogenomic databases

InParanoidiP87152.
KOiK11359.
OMAiDDEPIMS.
OrthoDBiEOG092C1TLO.

Miscellaneous databases

PROiP87152.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR006565. BTP.
[Graphical view]
PfamiPF07524. Bromo_TP. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM00576. BTP. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPT7_SCHPO
AccessioniPrimary (citable) accession number: P87152
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: April 18, 2012
Last modified: November 30, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.