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Protein

Transcriptional activator spt7

Gene

spt7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • chromatin remodeling Source: PomBase
  • histone acetylation Source: PomBase
  • regulation of transcription by RNA polymerase II Source: PomBase
  • transcription by RNA polymerase II Source: PomBase

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator spt7
Gene namesi
Name:spt7
ORF Names:SPBC25H2.11c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC25H2.11c
PomBaseiSPBC25H2.11c spt7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003103281 – 992Transcriptional activator spt7Add BLAST992

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei475Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP87152
PaxDbiP87152
PRIDEiP87152

PTM databases

iPTMnetiP87152

Interactioni

Subunit structurei

Component of the SAGA, SALSA and SLIK complexes.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi276936, 21 interactors
IntActiP87152, 2 interactors
MINTiP87152
STRINGi4896.SPBC25H2.11c.1

Structurei

3D structure databases

SMRiP87152
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini329 – 399BromoPROSITE-ProRule annotationAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi128 – 131Poly-Glu4
Compositional biasi149 – 154Poly-Asp6

Keywords - Domaini

Bromodomain

Phylogenomic databases

InParanoidiP87152
KOiK11359
OMAiIMSSRGR
OrthoDBiEOG092C1TLO

Family and domain databases

Gene3Di1.10.20.10, 1 hit
1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR006565 BTP
IPR009072 Histone-fold
IPR037782 Spt7
PANTHERiPTHR22880:SF223 PTHR22880:SF223, 1 hit
PfamiView protein in Pfam
PF07524 Bromo_TP, 1 hit
PF00439 Bromodomain, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SM00576 BTP, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P87152-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METNFEDSKS LDEPVLHDIA IALLKNDYWS LYLSPEQKRK YISILNDTLL
60 70 80 90 100
WNRFINVIEW DKLCDEKDSN GSNDDEEDDL DITTLFRCRC MIFDAKINPA
110 120 130 140 150
LFDLSSTSSG SIEHVDHQNI SLEASLAEEE ERKKGDAKKS EATGRQLFDD
160 170 180 190 200
DDFDESDAED SSKATITLDL QKDKSLRKSI IDLKSVDIDD MDTSGFAAIE
210 220 230 240 250
SNKALSNISF NYVYYTLEND SENINEVKKF EDEEDTSTPN TSSFQNNSSS
260 270 280 290 300
LDLSDNLSLN SKFGSLTSSF KYLLQYLEGN RSKINATDAD VKQLLSDVKK
310 320 330 340 350
NKSKWANDQR IGQEELYEAA EKVVLELRSY TEHSLAFLTK VSKRDAPDYY
360 370 380 390 400
TVIKEPMDLG TILRNLKNLH YNSKKEFVHD LMLIWSNCFL YNSHPDHPLR
410 420 430 440 450
VHAQFMKDKS LELINLIPDI VIQSRKDYDD SLIEAELESD EESTAETSKH
460 470 480 490 500
VTSKKTSSRG GQTQQAVEVH TDANSPEENN TPVTKKEVET SKPPAVSGST
510 520 530 540 550
PPVNEAAVIE SSNTLEKEPL SDVATEYWKI KTKDIRESHI LNNRRILKSL
560 570 580 590 600
QFIETELPMI RKPTAMSAFI DREVAYGSID CLPMDKGDFE PIMKLDTTPL
610 620 630 640 650
LEYDVGSGVP MTAGSVLETE SEEDLYFRDY SLFEINRNTP GVPSLMYKNI
660 670 680 690 700
AKMQEIRKLC NKIQTVRQLQ LPQPFYYEHH KSHVPFANNE PILLDIPQNY
710 720 730 740 750
DNMSSFKPLA HDVLKKLCTI ILFHAGFESF QMGALDALTE IAADYMAKMG
760 770 780 790 800
AVMDQYLIYG KDKSQQEIVG QTLGELGVDD VNDLISYVYH DVERQSVKLL
810 820 830 840 850
EIHQRLQRHF VELLRPALSE RNDEEAIFNQ NGESFVTGNF SYETGDDFFG
860 870 880 890 900
LRELGLDREL GLDSLSVPLH LLQSRLRSNM SWQPEATIKG DQEYAPPPKY
910 920 930 940 950
PPITAESISN EIGLIQGFLK KNLEEFGLDE LLEDEDIRPR SKPPRPRLPP
960 970 980 990
NGKITTGRKR IASSVFLNQS LRKKRCLKEN EQGTEVTTLP EE
Length:992
Mass (Da):112,901
Last modified:April 18, 2012 - v2
Checksum:i461B9F7A1848CBC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB08777.2
PIRiT40006
RefSeqiNP_596356.2, NM_001022276.2

Genome annotation databases

EnsemblFungiiSPBC25H2.11c.1; SPBC25H2.11c.1:pep; SPBC25H2.11c
GeneIDi2540408
KEGGispo:SPBC25H2.11c

Similar proteinsi

Entry informationi

Entry nameiSPT7_SCHPO
AccessioniPrimary (citable) accession number: P87152
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: April 18, 2012
Last modified: April 25, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health