Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial inner membrane magnesium transporter mrs2

Gene

mrs2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

ReactomeiR-SPO-5223345. Miscellaneous transport and binding events.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial inner membrane magnesium transporter mrs2
Alternative name(s):
RNA-splicing protein mrs2
Gene namesi
Name:mrs2
ORF Names:SPBC25H2.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC25H2.08c.
PomBaseiSPBC25H2.08c. mrs2.

Subcellular locationi

  • Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei331 – 35121HelicalSequence analysisAdd
BLAST
Transmembranei370 – 39021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB
  • mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4949MitochondrionSequence analysisAdd
BLAST
Chaini50 – 422373Mitochondrial inner membrane magnesium transporter mrs2PRO_0000043248Add
BLAST

Interactioni

Subunit structurei

Homopentamer. Forms homooligomers. Interacts with MFM1.By similarity

Protein-protein interaction databases

BioGridi276914. 1 interaction.
MINTiMINT-4692628.

Structurei

3D structure databases

ProteinModelPortaliP87149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi355 – 3584YGMN

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000248323.
InParanoidiP87149.
KOiK16075.
OMAiYLLEAYY.
OrthoDBiEOG7SXWCP.
PhylomeDBiP87149.

Family and domain databases

InterProiIPR002523. MgTranspt_CorA/ZnTranspt_ZntB.
[Graphical view]
PfamiPF01544. CorA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P87149-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLIVGFNLR TSIASFSPIC RSLFLFPKYR SRIIRPVVLL EKPFDKHFYA
60 70 80 90 100
TDSNPLITGF PETSKNCPPS VAATKNRLLM NCTEFDDHGN VRVISGDFKK
110 120 130 140 150
MDLCKQNGLL PRDLRKLNTS INSIVPVILV REGSILINLL HIRALIKANS
160 170 180 190 200
VLLFDVYGSQ HSHSQSQFIY ELEGRLKQKS SDFGWLPYEM RALETILVSV
210 220 230 240 250
VNTLDSELHV LHNLVSDLLA DFELDINQER LRTLLIFSKR LSGFLKKATL
260 270 280 290 300
IRDVLDELLE QDQDLAGMYL TERLKTGKPR DLDKHDEVEL LLETYCKQVD
310 320 330 340 350
EIVQQTDNLV GNIRSTEEIC NIMLDANRNS LMLLGLKLSA MTLGLGFGAV
360 370 380 390 400
VASLYGMNLQ NGLENHPYAF YITTGSIFAF AAFLSSLGIL KIRRLKRIQM
410 420
ALYHRCNLPI SLDPRSLRPP YL
Length:422
Mass (Da):47,888
Last modified:July 1, 1997 - v1
Checksum:i573A3371720262EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB08784.1.
PIRiT40003.
RefSeqiNP_596358.1. NM_001022279.2.

Genome annotation databases

EnsemblFungiiSPBC25H2.08c.1; SPBC25H2.08c.1:pep; SPBC25H2.08c.
GeneIDi2540385.
KEGGispo:SPBC25H2.08c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB08784.1.
PIRiT40003.
RefSeqiNP_596358.1. NM_001022279.2.

3D structure databases

ProteinModelPortaliP87149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276914. 1 interaction.
MINTiMINT-4692628.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC25H2.08c.1; SPBC25H2.08c.1:pep; SPBC25H2.08c.
GeneIDi2540385.
KEGGispo:SPBC25H2.08c.

Organism-specific databases

EuPathDBiFungiDB:SPBC25H2.08c.
PomBaseiSPBC25H2.08c. mrs2.

Phylogenomic databases

HOGENOMiHOG000248323.
InParanoidiP87149.
KOiK16075.
OMAiYLLEAYY.
OrthoDBiEOG7SXWCP.
PhylomeDBiP87149.

Enzyme and pathway databases

ReactomeiR-SPO-5223345. Miscellaneous transport and binding events.

Miscellaneous databases

NextBioi20801513.
PROiP87149.

Family and domain databases

InterProiIPR002523. MgTranspt_CorA/ZnTranspt_ZntB.
[Graphical view]
PfamiPF01544. CorA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiMRS2_SCHPO
AccessioniPrimary (citable) accession number: P87149
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 1, 1997
Last modified: April 13, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.