Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial import inner membrane translocase subunit tim22

Gene

tim22

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit tim22
Gene namesi
Name:tim22
ORF Names:SPBC25H2.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC25H2.04c
PomBaseiSPBC25H2.04c tim22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002103001 – 175Mitochondrial import inner membrane translocase subunit tim22Add BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 119By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP87146
PaxDbiP87146
PRIDEiP87146

Interactioni

Subunit structurei

Component of the TIM22 complex, whose core is composed of TIM22 and TIM54, associated with the 70 kDa heterohexamer composed of TIM9 and TIM10 (or TIM8 and TIM13).By similarity

Protein-protein interaction databases

STRINGi4896.SPBC25H2.04c.1

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000161169
InParanoidiP87146
KOiK17790
OMAiTYAGGIT
OrthoDBiEOG092C5C6F
PhylomeDBiP87146

Family and domain databases

InterProiView protein in InterPro
IPR003397 Tim17/Tim22/Tim23/PMP24
PfamiView protein in Pfam
PF02466 Tim17, 1 hit

Sequencei

Sequence statusi: Complete.

P87146-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSGLLPPN LGGNSPNADG NLTPEEKAAL QQAKIIGYMN RISESCVFKS
60 70 80 90 100
SMAGVLGFGL GGIFGMFISS LDLQHIDPKI YEKPFREQIR IQARDMGSRS
110 120 130 140 150
FSTAKNFGLL GLIYSGSECC IEAFRAKTDI YNAIAAGVFT GGALAVRSGP
160 170
KAIVLGGAGF GLFSYGIEKY MHWGE
Length:175
Mass (Da):18,641
Last modified:July 1, 1997 - v1
Checksum:i4622CE72C5FCB8B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB08780.1
PIRiT39999
RefSeqiNP_596362.1, NM_001022283.2

Genome annotation databases

EnsemblFungiiSPBC25H2.04c.1; SPBC25H2.04c.1:pep; SPBC25H2.04c
GeneIDi2540483
KEGGispo:SPBC25H2.04c

Similar proteinsi

Entry informationi

Entry nameiTIM22_SCHPO
AccessioniPrimary (citable) accession number: P87146
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health