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Protein

Protein VAC14 homolog

Gene

SPBC25H2.03

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Regulates the synthesis of PtdIns(3,5)P2 by positive activation of FAB1 and by controlling FIG4 localization (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-SPO-1660514. Synthesis of PIPs at the Golgi membrane.
R-SPO-1660516. Synthesis of PIPs at the early endosome membrane.
R-SPO-1660517. Synthesis of PIPs at the late endosome membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein VAC14 homolog
Gene namesi
ORF Names:SPBC25H2.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC25H2.03.
PomBaseiSPBC25H2.03.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • fungal-type vacuole membrane Source: PomBase
  • PAS complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 811811Protein VAC14 homologPRO_0000116490Add
BLAST

Proteomic databases

MaxQBiP87145.

Interactioni

Subunit structurei

Component of the PI(3,5)P2 regulatory complex, composed of ATG18, FIG4, FAB1, VAC14 and VAC7. VAC14 nucleates the assembly of the complex and serves as a scaffold (By similarity).By similarity

Protein-protein interaction databases

BioGridi277017. 25 interactions.
MINTiMINT-4692601.

Structurei

3D structure databases

ProteinModelPortaliP87145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati81 – 11939HEAT 1Add
BLAST
Repeati122 – 16039HEAT 2Add
BLAST
Repeati240 – 27839HEAT 3Add
BLAST
Repeati334 – 37239HEAT 4Add
BLAST
Repeati375 – 41238HEAT 5Add
BLAST
Repeati431 – 46939HEAT 6Add
BLAST
Repeati472 – 51039HEAT 7Add
BLAST

Sequence similaritiesi

Belongs to the VAC14 family.Curated
Contains 7 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000216640.
InParanoidiP87145.
KOiK15305.
OMAiCIEKEED.
OrthoDBiEOG70PC63.
PhylomeDBiP87145.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR026825. Vac14.
IPR032878. Vac14_Fab1-bd.
IPR021841. VAC14_Fig4p-bd.
[Graphical view]
PANTHERiPTHR16023. PTHR16023. 3 hits.
PfamiPF12755. Vac14_Fab1_bd. 1 hit.
PF11916. Vac14_Fig4_bd. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

P87145-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNLLVRGLT HKLYDKRKAT AYELERVVKG YLENDETEKI RAVISQLAND
60 70 80 90 100
FVYSPARGPN ATFGGLIGLA AVAIALGPKI DSYMESILLP VLYCFNDSDS
110 120 130 140 150
KIRYYACESM YNIGKVAKGE VFRYFNLIFD VLCKLFADTE ITVKNGAELL
160 170 180 190 200
DRLIKDIVMQ QAATYMSSAE DIKNFKEGPV SSSIQDVPVM STEQPRMHTF
210 220 230 240 250
SLSELVPLLS ERLYVINPNT RMFLVSWIRL LDSIPDLEFI SYLPFLLDGL
260 270 280 290 300
MNYLSDPNES IRIVTSNCLY DFLREIQKIA KVKYHILQRD EESEPDFFDS
310 320 330 340 350
MVRRNMSDAE LKEISDYVES SLRDGSFILE AHIQIDYKRI LEIIIDHLGS
360 370 380 390 400
SVPLIQEKAL KWLFEFIYIA PKDVLLQIPK VLENLLPLMS NDENMRQSAK
410 420 430 440 450
DLSQNLVILV SKIMDIEFSG SETNNKDNSL SVDFRSLIEV LQKLLSNDNE
460 470 480 490 500
ETRLCALEWV LLLQRRTGGK LINMHDPIFQ TLLLQLSDPS DLVVSRTLEL
510 520 530 540 550
LAHIAISHKS VNLVPFLKSL LQMFAEDRKF LNSRGNLIIR QLCNYIEGER
560 570 580 590 600
VYTSFAGILE TEENLELASI MVEVLNNNLF TAPELYDLRK KLKQSAPKLQ
610 620 630 640 650
NIFTTLYTAW CHNSIAVFSL CLLSQNYEHA ANLLSVFAEI EFNIDMLIQL
660 670 680 690 700
DKLVQLIESP VFTYMRLQLL EPEKYPYLHK ALYGILMLLP QSSAFRTLRD
710 720 730 740 750
RLQCSSTPRT NTILANERLP RSRRDDPYWT DLLERLKAVQ LSHQNNYREP
760 770 780 790 800
IRATRLALAG ALPSTPTATT ISTTTSASGI TTTASNSRDS FITRLPPTAA
810
LSTGARKKPK Q
Length:811
Mass (Da):92,453
Last modified:July 1, 1997 - v1
Checksum:iF2D49FFE4BEB6B70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB08779.1.
PIRiT39998.
RefSeqiNP_596363.1. NM_001022284.2.

Genome annotation databases

EnsemblFungiiSPBC25H2.03.1; SPBC25H2.03.1:pep; SPBC25H2.03.
GeneIDi2540489.
KEGGispo:SPBC25H2.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB08779.1.
PIRiT39998.
RefSeqiNP_596363.1. NM_001022284.2.

3D structure databases

ProteinModelPortaliP87145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277017. 25 interactions.
MINTiMINT-4692601.

Proteomic databases

MaxQBiP87145.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC25H2.03.1; SPBC25H2.03.1:pep; SPBC25H2.03.
GeneIDi2540489.
KEGGispo:SPBC25H2.03.

Organism-specific databases

EuPathDBiFungiDB:SPBC25H2.03.
PomBaseiSPBC25H2.03.

Phylogenomic databases

HOGENOMiHOG000216640.
InParanoidiP87145.
KOiK15305.
OMAiCIEKEED.
OrthoDBiEOG70PC63.
PhylomeDBiP87145.

Enzyme and pathway databases

ReactomeiR-SPO-1660514. Synthesis of PIPs at the Golgi membrane.
R-SPO-1660516. Synthesis of PIPs at the early endosome membrane.
R-SPO-1660517. Synthesis of PIPs at the late endosome membrane.

Miscellaneous databases

PROiP87145.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR026825. Vac14.
IPR032878. Vac14_Fab1-bd.
IPR021841. VAC14_Fig4p-bd.
[Graphical view]
PANTHERiPTHR16023. PTHR16023. 3 hits.
PfamiPF12755. Vac14_Fab1_bd. 1 hit.
PF11916. Vac14_Fig4_bd. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiVAC14_SCHPO
AccessioniPrimary (citable) accession number: P87145
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 1, 1997
Last modified: July 6, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.