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Protein

Protein VAC14 homolog

Gene

SPBC25H2.03

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Regulates the synthesis of PtdIns(3,5)P2 by positive activation of FAB1 and by controlling FIG4 localization (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-SPO-1660514 Synthesis of PIPs at the Golgi membrane
R-SPO-1660516 Synthesis of PIPs at the early endosome membrane
R-SPO-1660517 Synthesis of PIPs at the late endosome membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Protein VAC14 homolog
Gene namesi
ORF Names:SPBC25H2.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC25H2.03
PomBaseiSPBC25H2.03

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001164901 – 811Protein VAC14 homologAdd BLAST811

Proteomic databases

MaxQBiP87145
PaxDbiP87145
PRIDEiP87145

Interactioni

Subunit structurei

Component of the PI(3,5)P2 regulatory complex, composed of ATG18, FIG4, FAB1, VAC14 and VAC7. VAC14 nucleates the assembly of the complex and serves as a scaffold (By similarity).By similarity

Protein-protein interaction databases

BioGridi277017, 25 interactors
STRINGi4896.SPBC25H2.03.1

Structurei

3D structure databases

ProteinModelPortaliP87145
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati81 – 119HEAT 1Add BLAST39
Repeati122 – 160HEAT 2Add BLAST39
Repeati240 – 278HEAT 3Add BLAST39
Repeati334 – 372HEAT 4Add BLAST39
Repeati375 – 412HEAT 5Add BLAST38
Repeati431 – 469HEAT 6Add BLAST39
Repeati472 – 510HEAT 7Add BLAST39

Sequence similaritiesi

Belongs to the VAC14 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000216640
InParanoidiP87145
KOiK15305
OMAiCIEKEED
OrthoDBiEOG092C0MJZ
PhylomeDBiP87145

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR026825 Vac14
IPR032878 Vac14_Fab1-bd
IPR021841 VAC14_Fig4p-bd
PANTHERiPTHR16023 PTHR16023, 1 hit
PfamiView protein in Pfam
PF12755 Vac14_Fab1_bd, 1 hit
PF11916 Vac14_Fig4_bd, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits

Sequencei

Sequence statusi: Complete.

P87145-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNLLVRGLT HKLYDKRKAT AYELERVVKG YLENDETEKI RAVISQLAND
60 70 80 90 100
FVYSPARGPN ATFGGLIGLA AVAIALGPKI DSYMESILLP VLYCFNDSDS
110 120 130 140 150
KIRYYACESM YNIGKVAKGE VFRYFNLIFD VLCKLFADTE ITVKNGAELL
160 170 180 190 200
DRLIKDIVMQ QAATYMSSAE DIKNFKEGPV SSSIQDVPVM STEQPRMHTF
210 220 230 240 250
SLSELVPLLS ERLYVINPNT RMFLVSWIRL LDSIPDLEFI SYLPFLLDGL
260 270 280 290 300
MNYLSDPNES IRIVTSNCLY DFLREIQKIA KVKYHILQRD EESEPDFFDS
310 320 330 340 350
MVRRNMSDAE LKEISDYVES SLRDGSFILE AHIQIDYKRI LEIIIDHLGS
360 370 380 390 400
SVPLIQEKAL KWLFEFIYIA PKDVLLQIPK VLENLLPLMS NDENMRQSAK
410 420 430 440 450
DLSQNLVILV SKIMDIEFSG SETNNKDNSL SVDFRSLIEV LQKLLSNDNE
460 470 480 490 500
ETRLCALEWV LLLQRRTGGK LINMHDPIFQ TLLLQLSDPS DLVVSRTLEL
510 520 530 540 550
LAHIAISHKS VNLVPFLKSL LQMFAEDRKF LNSRGNLIIR QLCNYIEGER
560 570 580 590 600
VYTSFAGILE TEENLELASI MVEVLNNNLF TAPELYDLRK KLKQSAPKLQ
610 620 630 640 650
NIFTTLYTAW CHNSIAVFSL CLLSQNYEHA ANLLSVFAEI EFNIDMLIQL
660 670 680 690 700
DKLVQLIESP VFTYMRLQLL EPEKYPYLHK ALYGILMLLP QSSAFRTLRD
710 720 730 740 750
RLQCSSTPRT NTILANERLP RSRRDDPYWT DLLERLKAVQ LSHQNNYREP
760 770 780 790 800
IRATRLALAG ALPSTPTATT ISTTTSASGI TTTASNSRDS FITRLPPTAA
810
LSTGARKKPK Q
Length:811
Mass (Da):92,453
Last modified:July 1, 1997 - v1
Checksum:iF2D49FFE4BEB6B70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB08779.1
PIRiT39998
RefSeqiNP_596363.1, NM_001022284.2

Genome annotation databases

EnsemblFungiiSPBC25H2.03.1; SPBC25H2.03.1:pep; SPBC25H2.03
GeneIDi2540489
KEGGispo:SPBC25H2.03

Similar proteinsi

Entry informationi

Entry nameiVAC14_SCHPO
AccessioniPrimary (citable) accession number: P87145
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health