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P87144 (SYTC_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Threonine--tRNA ligase, cytoplasmic
EC=6.1.1.3
Alternative name(s):
Threonyl-tRNA synthetase
Short name=ThrRS
Gene names
Name:ths1
ORF Names:SPBC25H2.02
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length703 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processthreonyl-tRNA aminoacylation

Inferred from sequence or structural similarity. Source: GeneDB_Spombe

   Cellular componentcytosol

Inferred from direct assay. Source: GeneDB_Spombe

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

threonine-tRNA ligase activity

Inferred from sequence or structural similarity. Source: GeneDB_Spombe

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 703703Threonine--tRNA ligase, cytoplasmic
PRO_0000101124

Sequences

Sequence LengthMass (Da)Tools
P87144 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 518F29F100C73553

FASTA70380,138
        10         20         30         40         50         60 
MSAAAVKGVQ ASLDNLSLEI PFIQHRLDLF DKLQKEYKES LATKPREEID ITLPDGKVIK 

        70         80         90        100        110        120 
GTSWETTPIS IAASISKGLA DRVTVAIVNG EPWDLTRPLE ASCTLKLCDF NDPEGKRVFW 

       130        140        150        160        170        180 
HSSAHILGEA TELSFHCHLC IGPPTDEGFF YEMGIDNGRV ITNDDYSSIE SYAKQAIKQK 

       190        200        210        220        230        240 
QPFERLVISK EGLLEMFRYN KYKQYIIQTK IPDGASTTVY RCGPLIDLCT GPHVPHTGRI 

       250        260        270        280        290        300 
KSFAVTKNSS SYFLGDAKND SLQRVYGISF PDNKQMQEYK TFLAEAAKRD HRKIGRDQEL 

       310        320        330        340        350        360 
FFFNEISPGS CFFLPHGARI YNTLLKYMRY QYSKRGYQEV ITPNMYNVNL WKTSGHWNNY 

       370        380        390        400        410        420 
SENMFSFDIE KEKYALKPMN CPGHCVMFKS RDRSYRDLPW RVADFGVLHR NEFSGALSGL 

       430        440        450        460        470        480 
TRVRRFQQDD AHIFCTPDQV RSEIEGCFDF LKEVYGTFGF TFHLELSTRP EEKYLGDLAT 

       490        500        510        520        530        540 
WDKAEAQLKA ALDASGYKWE LNAGDGAFYG PKIDITVFDA LKRQHQCATI QLDFQLPERF 

       550        560        570        580        590        600 
QLEFHAPASA EEAKESGNNN KYTRPVMVHR AILGSLERMI AILTEHYAGK WPFWMSPRQV 

       610        620        630        640        650        660 
CIIPVSAAAY NYADKVHNIL SEADIFVDTD KSDNTLPKKI RNAQLAQYNF IFVVGAEEES 

       670        680        690        700 
TNSVNVRNRD DPKKQSKGST VAVEEVVKKL LKLKESKSLI NDL

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329671 Genomic DNA. Translation: CAB08788.1.
PIRT39997.
RefSeqNP_596364.1. NM_001022285.1.

3D structure databases

ProteinModelPortalP87144.
ModBaseSearch...

Protein-protein interaction databases

STRINGP87144.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC25H2.02.1; SPBC25H2.02.1:pep; SPBC25H2.02.
GeneID2540550.
GenomeReviewsGene locus ths1 in contig CU329671_GR.
KEGGspo:SPBC25H2.02.
NMPDRfig|4896.1.peg.2230.

Organism-specific databases

GeneDB_SpombeSPBC25H2.02.

Phylogenomic databases

eggNOGfuNOG05792.
GeneTreeEFGT00050000004683.
HOGENOMHBG352811.
OMAHYAENMF.
OrthoDBEOG4PP1R2.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-004377-MONOMER.

Gene expression databases

ArrayExpressP87144.

Family and domain databases

InterProIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_ferredoxin-type.
IPR004095. TGS.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-synth_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR012947. tRNA_SAD.
[Graphical view]
Gene3DG3DSA:3.40.50.800. Anticodon_bd. 1 hit.
G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit.
KOK01868.
PfamPF03129. HGTP_anticodon. 1 hit.
PF02824. TGS. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSPR01047. TRNASYNTHTHR.
SMARTSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMSSF52954. Anticodon_bd. 1 hit.
SSF81271. TGS-like. 1 hit.
SSF55186. Thr/Ala-tRNA-synth_IIc_edit. 1 hit.
TIGRFAMsTIGR00418. ThrS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYTC_SCHPO
AccessionPrimary (citable) accession number: P87144
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: January 25, 2012
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents