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Protein

Heat shock protein 70 homolog C57A7.12

Gene

SPAC57A7.12

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi39 – 468ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 70 homolog C57A7.12
Gene namesi
ORF Names:SPAC57A7.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC57A7.12.
PomBaseiSPAC57A7.12.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Heat shock protein 70 homolog C57A7.12PRO_0000078399Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei86 – 861Phosphoserine1 Publication
Modified residuei500 – 5001Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP87142.

PTM databases

iPTMnetiP87142.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi278607. 2 interactions.
IntActiP87142. 1 interaction.
MINTiMINT-4692564.

Structurei

3D structure databases

ProteinModelPortaliP87142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

HOGENOMiHOG000184645.
InParanoidiP87142.
OMAiTHIKVTK.
OrthoDBiEOG7P02SZ.
PhylomeDBiP87142.

Family and domain databases

Gene3Di2.60.34.10. 1 hit.
InterProiIPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 2 hits.

Sequencei

Sequence statusi: Complete.

P87142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLKLTKTLP FSENFIMADS EEYKTVIGIS FGNQNSSIAF NRDGKTDVLA
60 70 80 90 100
NEEGNRQIPS ILSYHGDQEY HGVQARGQLV RNADNSVTNF RDLLGKSHDE
110 120 130 140 150
LTLHHCHYSA NPVNVEGQIG FKITVQEDEE SDPKEKILTA HEASVRHLRR
160 170 180 190 200
LTESAEDFLG TKVNGCVMSV PVYFTDAQRK ALESAANEAG LPVLQLIHDP
210 220 230 240 250
AAVILALMYS EEVLIDKTVV VANFGATRSE VSVVSVKGGL MTILASVHDE
260 270 280 290 300
NLGGEQLTDV LVNFFAKEFE KKNGIDPRKN ARSLAKLRAQ CEITKRVLSN
310 320 330 340 350
GTTASAAVDS LADGIDFHSS INRLRYDLAA SATLNRMADL VTEAVEKANM
360 370 380 390 400
EPFDISEVIL AGGASNTPKL TSLMESIFPE QTIIRSSSSV TPLQLDPSEL
410 420 430 440 450
TAIGSGVQAS LIGHFDAADI AASTDAQVVD VPHLTAPIGI NEGENFVTIF
460 470 480 490 500
DIETALPARK TVEVIAPKEG AAFIPIYEAE RSVKVTKVEP EPIDEEEAFS
510 520 530 540 550
DDEEEEPEEI KERIAIPKTL IATITLPDVS PNAKIELVLQ IDAEGKLTAS
560
ARPKDGKGTN VRGSTA
Length:566
Mass (Da):61,286
Last modified:February 1, 2005 - v3
Checksum:i9381A1793027D93B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631S → P in BAA13923 (PubMed:9501991).Curated
Sequence conflicti103 – 1031L → H in BAA13923 (PubMed:9501991).Curated
Sequence conflicti110 – 1101A → S in BAA13923 (PubMed:9501991).Curated
Sequence conflicti128 – 1281D → G in BAA13923 (PubMed:9501991).Curated
Sequence conflicti285 – 2851A → V in BAA13923 (PubMed:9501991).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB08770.1.
D89262 mRNA. Translation: BAA13923.1.
PIRiT38942.
T43188.
RefSeqiNP_593369.1. NM_001018801.2.

Genome annotation databases

EnsemblFungiiSPAC57A7.12.1; SPAC57A7.12.1:pep; SPAC57A7.12.
GeneIDi2542131.
KEGGispo:SPAC57A7.12.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB08770.1.
D89262 mRNA. Translation: BAA13923.1.
PIRiT38942.
T43188.
RefSeqiNP_593369.1. NM_001018801.2.

3D structure databases

ProteinModelPortaliP87142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278607. 2 interactions.
IntActiP87142. 1 interaction.
MINTiMINT-4692564.

PTM databases

iPTMnetiP87142.

Proteomic databases

MaxQBiP87142.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC57A7.12.1; SPAC57A7.12.1:pep; SPAC57A7.12.
GeneIDi2542131.
KEGGispo:SPAC57A7.12.

Organism-specific databases

EuPathDBiFungiDB:SPAC57A7.12.
PomBaseiSPAC57A7.12.

Phylogenomic databases

HOGENOMiHOG000184645.
InParanoidiP87142.
OMAiTHIKVTK.
OrthoDBiEOG7P02SZ.
PhylomeDBiP87142.

Miscellaneous databases

NextBioi20803203.
PROiP87142.

Family and domain databases

Gene3Di2.60.34.10. 1 hit.
InterProiIPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-566.
    Strain: PR745.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86 AND SER-500, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiYDMC_SCHPO
AccessioniPrimary (citable) accession number: P87142
Secondary accession number(s): P78911
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: April 13, 2016
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.