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Protein

Target of rapamycin complex 1 subunit mip1

Gene

mip1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Tor2 is essential for growth. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Represses mating, meiosis and sporulation efficiency by interfering with the functions of the transcription factor ste11 and the meiosis-promoting RNA-binding protein mei2.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processMeiosis, Sporulation

Enzyme and pathway databases

ReactomeiR-SPO-3371571 HSF1-dependent transactivation

Names & Taxonomyi

Protein namesi
Recommended name:
Target of rapamycin complex 1 subunit mip11 Publication
Short name:
TORC1 subunit mip1
Gene namesi
Name:mip11 Publication
ORF Names:SPAC57A7.11Imported
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC57A7.11
PomBaseiSPAC57A7.11 mip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510781 – 1313Target of rapamycin complex 1 subunit mip1Add BLAST1313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei834Phosphoserine1 Publication1
Modified residuei837Phosphoserine1 Publication1 Publication1
Modified residuei882Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP87141
PaxDbiP87141
PRIDEiP87141

PTM databases

iPTMnetiP87141

Interactioni

Subunit structurei

The target of rapamycin complex 1 (TORC1) is composed of at least mip1, pop3/wat1, tco89, toc1 and tor2.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi278868, 8 interactors
IntActiP87141, 1 interactor
STRINGi4896.SPAC57A7.11.1

Structurei

3D structure databases

ProteinModelPortaliP87141
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati986 – 1029WD 1Add BLAST44
Repeati1033 – 1074WD 2Add BLAST42
Repeati1087 – 1126WD 3Add BLAST40
Repeati1130 – 1170WD 4Add BLAST41
Repeati1176 – 1216WD 5Add BLAST41
Repeati1219 – 1259WD 6Add BLAST41
Repeati1268 – 1308WD 7Add BLAST41

Sequence similaritiesi

Belongs to the WD repeat RAPTOR family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000184479
InParanoidiP87141
KOiK07204
OMAiYIHLAAC
OrthoDBiEOG092C09V4
PhylomeDBiP87141

Family and domain databases

Gene3Di1.25.10.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR004083 Raptor
IPR029347 Raptor_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR12848 PTHR12848, 1 hit
PfamiView protein in Pfam
PF14538 Raptor_N, 1 hit
SMARTiView protein in SMART
SM01302 Raptor_N, 1 hit
SM00320 WD40, 6 hits
SUPFAMiSSF48371 SSF48371, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

P87141-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDRISEVSG SSRARRSVLS YGTTETGSDR YTENSNIATE NGVDTASSMI
60 70 80 90 100
DGIQSGFPQP RHGFEEEYNN AEYINMLEQV FYMYYTDKRH RGVISKKNAE
110 120 130 140 150
PTETIHDWRM RERLKTVSAA LLVCLNIGVD PPDVIKPNPA AKYECWIDPF
160 170 180 190 200
SLPASKALEA IGKNLQQQYE TLSMRTRYRH YLDPAIEEVK KLCIGQRRNA
210 220 230 240 250
KEERILFHYN GHGVPMPTAS GEIWVFNKNY TQYIPVSLYD LQSWLGAPCI
260 270 280 290 300
YVYDCSAAGN IIVNFNRFAE QRDKEALRIA KQNPNVLAMP SHTSCIQLAA
310 320 330 340 350
CGPKETLPMN PDLPADLFTS CLTSPIEISV RWYVLQNPFP NKLNLNMLLK
360 370 380 390 400
IPGRLQDRRT PLGELNWIFT AITDTIAWNV FPKHLFRRLF RQDLMVAALF
410 420 430 440 450
RNFLLAERIM LVHSCHPQSS PELPPTHDHP MWNSWDLAID NCLSQLPDML
460 470 480 490 500
DAESKGIAYE YKHSTFFSEQ LTAFEVWLSQ GLISRKPPDQ LPLVLQVLLS
510 520 530 540 550
QVHRLRALIL LSKFLDLGVW AVDLALSIGI FPYVLKLLQS PAIELKPVLV
560 570 580 590 600
FIWARILAVD DSCQADLLKD NGYGYFVQIL NPNSSIFPSS NISEHRAMCA
610 620 630 640 650
FILSVFCRGF PQGQLACLNP QVLSHCLSHL NSPDSLLRQW ACLCISQLWE
660 670 680 690 700
NYSEAKWSGT RDNAHVKLAE IIVDSVPEVR ASVLTAFTTF LGFPEKTEEV
710 720 730 740 750
VAVETYIAIA ALAALSDASP LVRHELVIFL SHFVVNYKKQ LMVVAYESSL
760 770 780 790 800
ADILEKKNHN SISASTIYET VWQAVLVLAA DPSIEISLAA EAIINYVYQS
810 820 830 840 850
MLNSELRESF LAFLLQHLPA LHKASLSKDT DTNSVTSDPK PHPFVPSVSE
860 870 880 890 900
NKILNRSFSL TRSLKGLALS LAGSDRASEL LSLNGENKPA ESNLNHLTSA
910 920 930 940 950
KVPGPPAFNE LEYQSELDMP LTSYLFDWSR KYFTEPQMRP NEDDEPGSIC
960 970 980 990 1000
YNQRLWRRNR NEKLIYRTRP LAEYSTNGRW NQQLMTFNNT IAPRKLMFHQ
1010 1020 1030 1040 1050
FEDQLITLGD KDIIQVWDWR RNRCLNSFKT SASATTNVTD MQLLNEDDVA
1060 1070 1080 1090 1100
LLMTGSSDGT IKLYRDYENE KVELVTSWNS LSDLVFGDRN ASLLMSWQQN
1110 1120 1130 1140 1150
CGHLLVAGDV RVIRIWDASK EICYANLPVR SSNSITSLTS DLVGCNIIVA
1160 1170 1180 1190 1200
GFSDGVLRVY DKRLPARDSL TDVWKEHSSE IVNVEMQSSG MRELISASSD
1210 1220 1230 1240 1250
GEVKLWDIRM NHSLQTFSTD NSGLTSLTVH SHAPVYATGS SNQSIKIWDT
1260 1270 1280 1290 1300
LGQNINTFRE NPRFLNQPKP SSLMCLKFHP HHLLLACGDN TDSRVNLYSC
1310
TKNEIHTDSP NEF
Length:1,313
Mass (Da):148,534
Last modified:July 1, 1997 - v1
Checksum:iC71B663B0171E7A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032552 Genomic DNA Translation: BAA84585.1
CU329670 Genomic DNA Translation: CAB08769.1
PIRiT38943
RefSeqiNP_593370.1, NM_001018802.2

Genome annotation databases

EnsemblFungiiSPAC57A7.11.1; SPAC57A7.11.1:pep; SPAC57A7.11
GeneIDi2542404
KEGGispo:SPAC57A7.11

Similar proteinsi

Entry informationi

Entry nameiMIP1_SCHPO
AccessioniPrimary (citable) accession number: P87141
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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