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Protein

Target of rapamycin complex 1 subunit mip1

Gene

mip1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Tor2 is essential for growth. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Represses mating, meiosis and sporulation efficiency by interfering with the functions of the transcription factor ste11 and the meiosis-promoting RNA-binding protein mei2.3 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Meiosis, Sporulation

Enzyme and pathway databases

ReactomeiR-SPO-3371571. HSF1-dependent transactivation.

Names & Taxonomyi

Protein namesi
Recommended name:
Target of rapamycin complex 1 subunit mip11 Publication
Short name:
TORC1 subunit mip1
Gene namesi
Name:mip11 Publication
ORF Names:SPAC57A7.11Imported
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC57A7.11.
PomBaseiSPAC57A7.11. mip1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • TORC1 complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13131313Target of rapamycin complex 1 subunit mip1PRO_0000051078Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei834 – 8341Phosphoserine1 Publication
Modified residuei837 – 8371Phosphoserine1 Publication1 Publication
Modified residuei882 – 8821Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP87141.

PTM databases

iPTMnetiP87141.

Interactioni

Subunit structurei

The target of rapamycin complex 1 (TORC1) is composed of at least mip1, pop3/wat1, tco89, toc1 and tor2.3 Publications

Protein-protein interaction databases

BioGridi278868. 8 interactions.
IntActiP87141. 1 interaction.
MINTiMINT-4692547.

Structurei

3D structure databases

ProteinModelPortaliP87141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati986 – 102944WD 1Add
BLAST
Repeati1033 – 107442WD 2Add
BLAST
Repeati1087 – 112640WD 3Add
BLAST
Repeati1130 – 117041WD 4Add
BLAST
Repeati1176 – 121641WD 5Add
BLAST
Repeati1219 – 125941WD 6Add
BLAST
Repeati1268 – 130841WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat RAPTOR family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000184479.
InParanoidiP87141.
KOiK07204.
OMAiNINTFRE.
PhylomeDBiP87141.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.130.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR004083. Raptor.
IPR029347. Raptor_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR12848. PTHR12848. 1 hit.
PfamiPF14538. Raptor_N. 1 hit.
[Graphical view]
SMARTiSM01302. Raptor_N. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P87141-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDRISEVSG SSRARRSVLS YGTTETGSDR YTENSNIATE NGVDTASSMI
60 70 80 90 100
DGIQSGFPQP RHGFEEEYNN AEYINMLEQV FYMYYTDKRH RGVISKKNAE
110 120 130 140 150
PTETIHDWRM RERLKTVSAA LLVCLNIGVD PPDVIKPNPA AKYECWIDPF
160 170 180 190 200
SLPASKALEA IGKNLQQQYE TLSMRTRYRH YLDPAIEEVK KLCIGQRRNA
210 220 230 240 250
KEERILFHYN GHGVPMPTAS GEIWVFNKNY TQYIPVSLYD LQSWLGAPCI
260 270 280 290 300
YVYDCSAAGN IIVNFNRFAE QRDKEALRIA KQNPNVLAMP SHTSCIQLAA
310 320 330 340 350
CGPKETLPMN PDLPADLFTS CLTSPIEISV RWYVLQNPFP NKLNLNMLLK
360 370 380 390 400
IPGRLQDRRT PLGELNWIFT AITDTIAWNV FPKHLFRRLF RQDLMVAALF
410 420 430 440 450
RNFLLAERIM LVHSCHPQSS PELPPTHDHP MWNSWDLAID NCLSQLPDML
460 470 480 490 500
DAESKGIAYE YKHSTFFSEQ LTAFEVWLSQ GLISRKPPDQ LPLVLQVLLS
510 520 530 540 550
QVHRLRALIL LSKFLDLGVW AVDLALSIGI FPYVLKLLQS PAIELKPVLV
560 570 580 590 600
FIWARILAVD DSCQADLLKD NGYGYFVQIL NPNSSIFPSS NISEHRAMCA
610 620 630 640 650
FILSVFCRGF PQGQLACLNP QVLSHCLSHL NSPDSLLRQW ACLCISQLWE
660 670 680 690 700
NYSEAKWSGT RDNAHVKLAE IIVDSVPEVR ASVLTAFTTF LGFPEKTEEV
710 720 730 740 750
VAVETYIAIA ALAALSDASP LVRHELVIFL SHFVVNYKKQ LMVVAYESSL
760 770 780 790 800
ADILEKKNHN SISASTIYET VWQAVLVLAA DPSIEISLAA EAIINYVYQS
810 820 830 840 850
MLNSELRESF LAFLLQHLPA LHKASLSKDT DTNSVTSDPK PHPFVPSVSE
860 870 880 890 900
NKILNRSFSL TRSLKGLALS LAGSDRASEL LSLNGENKPA ESNLNHLTSA
910 920 930 940 950
KVPGPPAFNE LEYQSELDMP LTSYLFDWSR KYFTEPQMRP NEDDEPGSIC
960 970 980 990 1000
YNQRLWRRNR NEKLIYRTRP LAEYSTNGRW NQQLMTFNNT IAPRKLMFHQ
1010 1020 1030 1040 1050
FEDQLITLGD KDIIQVWDWR RNRCLNSFKT SASATTNVTD MQLLNEDDVA
1060 1070 1080 1090 1100
LLMTGSSDGT IKLYRDYENE KVELVTSWNS LSDLVFGDRN ASLLMSWQQN
1110 1120 1130 1140 1150
CGHLLVAGDV RVIRIWDASK EICYANLPVR SSNSITSLTS DLVGCNIIVA
1160 1170 1180 1190 1200
GFSDGVLRVY DKRLPARDSL TDVWKEHSSE IVNVEMQSSG MRELISASSD
1210 1220 1230 1240 1250
GEVKLWDIRM NHSLQTFSTD NSGLTSLTVH SHAPVYATGS SNQSIKIWDT
1260 1270 1280 1290 1300
LGQNINTFRE NPRFLNQPKP SSLMCLKFHP HHLLLACGDN TDSRVNLYSC
1310
TKNEIHTDSP NEF
Length:1,313
Mass (Da):148,534
Last modified:July 1, 1997 - v1
Checksum:iC71B663B0171E7A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032552 Genomic DNA. Translation: BAA84585.1.
CU329670 Genomic DNA. Translation: CAB08769.1.
PIRiT38943.
RefSeqiNP_593370.1. NM_001018802.2.

Genome annotation databases

EnsemblFungiiSPAC57A7.11.1; SPAC57A7.11.1:pep; SPAC57A7.11.
GeneIDi2542404.
KEGGispo:SPAC57A7.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032552 Genomic DNA. Translation: BAA84585.1.
CU329670 Genomic DNA. Translation: CAB08769.1.
PIRiT38943.
RefSeqiNP_593370.1. NM_001018802.2.

3D structure databases

ProteinModelPortaliP87141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278868. 8 interactions.
IntActiP87141. 1 interaction.
MINTiMINT-4692547.

PTM databases

iPTMnetiP87141.

Proteomic databases

MaxQBiP87141.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC57A7.11.1; SPAC57A7.11.1:pep; SPAC57A7.11.
GeneIDi2542404.
KEGGispo:SPAC57A7.11.

Organism-specific databases

EuPathDBiFungiDB:SPAC57A7.11.
PomBaseiSPAC57A7.11. mip1.

Phylogenomic databases

HOGENOMiHOG000184479.
InParanoidiP87141.
KOiK07204.
OMAiNINTFRE.
PhylomeDBiP87141.

Enzyme and pathway databases

ReactomeiR-SPO-3371571. HSF1-dependent transactivation.

Miscellaneous databases

PROiP87141.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.130.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR004083. Raptor.
IPR029347. Raptor_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR12848. PTHR12848. 1 hit.
PfamiPF14538. Raptor_N. 1 hit.
[Graphical view]
SMARTiSM01302. Raptor_N. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel WD-repeat protein Mip1p facilitates function of the meiotic regulator Mei2p in fission yeast."
    Shinozaki-Yabana S., Watanabe Y., Yamamoto M.
    Mol. Cell. Biol. 20:1234-1242(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Fission yeast Tor2 promotes cell growth and represses cell differentiation."
    Alvarez B., Moreno S.
    J. Cell Sci. 119:4475-4485(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TOR2.
  4. "Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits."
    Hayashi T., Hatanaka M., Nagao K., Nakaseko Y., Kanoh J., Kokubu A., Ebe M., Yanagida M.
    Genes Cells 12:1357-1370(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE TORC1 COMPLEX, PHOSPHORYLATION AT SER-834 AND SER-882, IDENTIFICATION BY MASS SPECTROMETRY.
  5. "Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast."
    Matsuo T., Otsubo Y., Urano J., Tamanoi F., Yamamoto M.
    Mol. Cell. Biol. 27:3154-3164(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TOR2.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-837, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiMIP1_SCHPO
AccessioniPrimary (citable) accession number: P87141
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 1, 1997
Last modified: June 8, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.