ID   TIM17_SCHPO             Reviewed;         164 AA.
AC   P87130;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   27-MAR-2024, entry version 139.
DE   RecName: Full=Mitochondrial import inner membrane translocase subunit tim17;
DE   AltName: Full=Mitochondrial protein import protein 2;
GN   Name=tim17; ORFNames=SPAC3A12.16c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Essential component of the TIM23 complex, a complex that
CC       mediates the translocation of transit peptide-containing proteins
CC       across the mitochondrial inner membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the TIM23 complex, at least composed of tim23,
CC       tim17, tim50 and tim50. The complex interacts with the tim44 component
CC       of the PAM complex (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB08744.1; -; Genomic_DNA.
DR   PIR; T38684; T38684.
DR   RefSeq; NP_593342.1; NM_001018774.2.
DR   AlphaFoldDB; P87130; -.
DR   SMR; P87130; -.
DR   ComplexPortal; CPX-540; Mitochondrial inner membrane pre-sequence translocase complex.
DR   STRING; 284812.P87130; -.
DR   MaxQB; P87130; -.
DR   PaxDb; 4896-SPAC3A12-16c-1; -.
DR   EnsemblFungi; SPAC3A12.16c.1; SPAC3A12.16c.1:pep; SPAC3A12.16c.
DR   GeneID; 2543163; -.
DR   KEGG; spo:SPAC3A12.16c; -.
DR   PomBase; SPAC3A12.16c; tim17.
DR   VEuPathDB; FungiDB:SPAC3A12.16c; -.
DR   eggNOG; KOG1652; Eukaryota.
DR   HOGENOM; CLU_087811_3_0_1; -.
DR   InParanoid; P87130; -.
DR   OMA; CPWVILS; -.
DR   PhylomeDB; P87130; -.
DR   Reactome; R-SPO-1268020; Mitochondrial protein import.
DR   PRO; PR:P87130; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR   GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IBA:GO_Central.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IC:PomBase.
DR   GO; GO:0015450; F:protein-transporting ATPase activity; ISS:PomBase.
DR   GO; GO:0006886; P:intracellular protein transport; NAS:ComplexPortal.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; ISS:PomBase.
DR   InterPro; IPR005678; Tim17.
DR   NCBIfam; TIGR00980; 3a0801so1tim17; 1.
DR   PANTHER; PTHR10485:SF0; AT05822P-RELATED; 1.
DR   PANTHER; PTHR10485; MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17; 1.
DR   Pfam; PF02466; Tim17; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Protein transport; Reference proteome; Translocation; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..164
FT                   /note="Mitochondrial import inner membrane translocase
FT                   subunit tim17"
FT                   /id="PRO_0000210295"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DISULFID        11..78
FT                   /evidence="ECO:0000250|UniProtKB:P39515"
SQ   SEQUENCE   164 AA;  16901 MW;  4826B4895F115BCF CRC64;
     MASADHTRDP CPYVILNDFG AAFSMGTIGG AIWHSIKGWR NSPPGEKRIS AIAAAKTRAP
     VLGGNFGVWG GLFSTFDCAV KGVRRKEDPW NAIIAGFFTG GALAVRGGWR ATRNGAIGCA
     CILAVFEGLG IALGRMNAEY NRPVAPVIPD APASGSTSAA PAAV
//