Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA-directed RNA polymerase II subunit RPB11

Gene

rpb11

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • transcription by RNA polymerase II Source: PomBase

Keywordsi

Biological processTranscription

Enzyme and pathway databases

ReactomeiR-SPO-113418 Formation of the Early Elongation Complex
R-SPO-674695 RNA Polymerase II Pre-transcription Events
R-SPO-6781823 Formation of TC-NER Pre-Incision Complex
R-SPO-6782135 Dual incision in TC-NER
R-SPO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-SPO-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-SPO-72086 mRNA Capping
R-SPO-72165 mRNA Splicing - Minor Pathway
R-SPO-73776 RNA Polymerase II Promoter Escape
R-SPO-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-SPO-75953 RNA Polymerase II Transcription Initiation
R-SPO-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-SPO-77075 RNA Pol II CTD phosphorylation and interaction with CE

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase II subunit RPB11
Short name:
RNA polymerase II subunit B11
Alternative name(s):
DNA-directed RNA polymerase II 14.1 kDa polypeptide
Gene namesi
Name:rpb11
ORF Names:SPAC3A12.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3A12.07
PomBaseiSPAC3A12.07 rpb11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001493141 – 123DNA-directed RNA polymerase II subunit RPB11Add BLAST123

Proteomic databases

MaxQBiP87123
PaxDbiP87123
PRIDEiP87123

PTM databases

iPTMnetiP87123

Interactioni

Subunit structurei

Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi279544, 9 interactors
IntActiP87123, 2 interactors
STRINGi4896.SPAC3A12.07.1

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H0GX-ray3.65K/W1-123[»]
5U0Selectron microscopy7.80k1-123[»]
ProteinModelPortaliP87123
SMRiP87123
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP87123

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000179862
InParanoidiP87123
KOiK03008
OMAiMAGYKIA
OrthoDBiEOG092C5QHE
PhylomeDBiP87123

Family and domain databases

CDDicd06926 RNAP_II_RPB11, 1 hit
Gene3Di3.30.1360.10, 1 hit
InterProiView protein in InterPro
IPR037685 RBP11
IPR036603 RBP11-like
IPR009025 RBP11-like_dimer
IPR008193 RNA_pol_Rpb11_13-16kDa_CS
PfamiView protein in Pfam
PF13656 RNA_pol_L_2, 1 hit
SUPFAMiSSF55257 SSF55257, 1 hit
PROSITEiView protein in PROSITE
PS01154 RNA_POL_L_13KD, 1 hit

Sequencei

Sequence statusi: Complete.

P87123-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQPERYELI ELMGLPKVTY ELDSKSPNAA VVTLEKEDHT LANMLANQLL
60 70 80 90 100
SDERVLFAGY KVPHPLNHNF ILRVQTVEDC SPKQVIVDAA KSLITHLEEI
110 120
KVNFMREWEL KMISVEGVEM EFS
Length:123
Mass (Da):14,127
Last modified:July 1, 1997 - v1
Checksum:i73FAFDF2F468386E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89597 Genomic DNA Translation: BAA22806.1
D85902 mRNA Translation: BAA22801.1
AF027822 mRNA Translation: AAB92517.1
CU329670 Genomic DNA Translation: CAB08752.1
PIRiT38675
RefSeqiNP_593333.1, NM_001018765.2

Genome annotation databases

EnsemblFungiiSPAC3A12.07.1; SPAC3A12.07.1:pep; SPAC3A12.07
GeneIDi2543112
KEGGispo:SPAC3A12.07

Similar proteinsi

Entry informationi

Entry nameiRPB11_SCHPO
AccessioniPrimary (citable) accession number: P87123
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health