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Protein

ATP-dependent helicase fft1

Gene

fft1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for heterochromatin organization.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi439 – 4468ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent helicase fft1 (EC:3.6.4.12)
Alternative name(s):
Fun thirty-related protein 1
Gene namesi
Name:fft1
ORF Names:SPAC20G8.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC20G8.08c.
PomBaseiSPAC20G8.08c. fft1.

Subcellular locationi

GO - Cellular componenti

  • nuclear chromatin Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 944944ATP-dependent helicase fft1PRO_0000310747Add
BLAST

Proteomic databases

MaxQBiP87114.

Interactioni

Protein-protein interaction databases

BioGridi278468. 6 interactions.
MINTiMINT-4692360.

Structurei

3D structure databases

ProteinModelPortaliP87114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini426 – 592167Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini766 – 923158Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi543 – 5464DEGH box

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiP87114.
KOiK14439.
OMAiMAINAKY.
OrthoDBiEOG7WDNB3.
PhylomeDBiP87114.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P87114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRKDNKELI CIPSSSPPST PIREENYYLL TSSPIECSPI QQLDLSGSFK
60 70 80 90 100
NYSTTSSRAN GKKFGQLAMQ SRIFFDTTDH KKYVESSYAA YDPHDQPPER
110 120 130 140 150
DVSLKESSNK INPSNFFDSE QITKINAVKK RFPALDSEMI IATLEKFNWR
160 170 180 190 200
ENITIHKLTF QKLLGRGNST INKSAQKLNN QPIEKSSVDK ENAKRKRYVE
210 220 230 240 250
EGTKQGQKKK PLRVIELSDE ETNEDDLLGQ SPTACTTDAN IDNSIPENSD
260 270 280 290 300
KIEEVSIESS GPSEVEDEMS EYDVRVLNFL NESTLQEIVE VSGCESKVVE
310 320 330 340 350
YFISKRPFPS LEKAEALCQR NAHAATGKRK KSDGRNVGRK LVNSTYEVLQ
360 370 380 390 400
GFDAVDSLIA KCERYGAMIS NTMRSWHNLF DDKKMEQFLN TSTGSISYEY
410 420 430 440 450
NSQQPSSIAS GITLKSYQIV GLNWLCLMYK AKLSGILADE MGLGKTCQVI
460 470 480 490 500
SFLASLKEKG IQNRHLVVVP SSTLGNWLRE FEKFCPSLRV ESYSGTQSER
510 520 530 540 550
INKRYYLMDT DFDVLVTTYQ LASGSRDDRS FLRKQRFDIS IFDEGHYLKN
560 570 580 590 600
RMSERYKHLM NIPANFRLLI TGTPLQNNLK ELISLLAFML PKVFDNNMQG
610 620 630 640 650
LDIIYKIKTT SDGDIERAYL SQERISRAKT IMNPFILRRR KENVLSDLPP
660 670 680 690 700
KIQHVEYCHM EETQLSLYLS VLELKNLVNA NRENILMQLR KAALHQLLFR
710 720 730 740 750
SQYNLETLSL MSKRILREDA YLDANPQYIF EDMEVMSDFE LHKLADQYRH
760 770 780 790 800
LHPFALKGKP WMDSAKVKKL CSLLKKSRPN ERILIFSQFT QVLDILEYVL
810 820 830 840 850
NTLDLEFLRL DGSTPVETRQ QLIDDFHTNE NYKVFLLSTK SGGFGINLTC
860 870 880 890 900
ANIVILFDCS FNPFDDMQAE DRAHRVGQTR PVHVYRLITK NTIEENIRRL
910 920 930 940
ANTKLTLESS LTTDSEKIQK EISGELMKSL QMDGRVDTMD GSVV
Length:944
Mass (Da):108,252
Last modified:July 1, 1997 - v1
Checksum:i23A17A57C31F5E83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB08602.1.
PIRiT38130.
RefSeqiNP_593325.1. NM_001018756.2.

Genome annotation databases

EnsemblFungiiSPAC20G8.08c.1; SPAC20G8.08c.1:pep; SPAC20G8.08c.
GeneIDi2541983.
KEGGispo:SPAC20G8.08c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB08602.1.
PIRiT38130.
RefSeqiNP_593325.1. NM_001018756.2.

3D structure databases

ProteinModelPortaliP87114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278468. 6 interactions.
MINTiMINT-4692360.

Proteomic databases

MaxQBiP87114.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC20G8.08c.1; SPAC20G8.08c.1:pep; SPAC20G8.08c.
GeneIDi2541983.
KEGGispo:SPAC20G8.08c.

Organism-specific databases

EuPathDBiFungiDB:SPAC20G8.08c.
PomBaseiSPAC20G8.08c. fft1.

Phylogenomic databases

InParanoidiP87114.
KOiK14439.
OMAiMAINAKY.
OrthoDBiEOG7WDNB3.
PhylomeDBiP87114.

Miscellaneous databases

NextBioi20803065.
PROiP87114.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFFT1_SCHPO
AccessioniPrimary (citable) accession number: P87114
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 1, 1997
Last modified: November 11, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.