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Protein

ATP-dependent helicase fft1

Gene

fft1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for heterochromatin organization.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi439 – 446ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, DNA-binding, Helicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent helicase fft1 (EC:3.6.4.12)
Alternative name(s):
Fun thirty-related protein 1
Gene namesi
Name:fft1
ORF Names:SPAC20G8.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC20G8.08c
PomBaseiSPAC20G8.08c fft1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003107471 – 944ATP-dependent helicase fft1Add BLAST944

Proteomic databases

MaxQBiP87114
PaxDbiP87114
PRIDEiP87114

Interactioni

Protein-protein interaction databases

BioGridi278468, 6 interactors
STRINGi4896.SPAC20G8.08c.1

Structurei

3D structure databases

ProteinModelPortaliP87114
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini426 – 592Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST167
Domaini766 – 923Helicase C-terminalPROSITE-ProRule annotationAdd BLAST158

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi543 – 546DEGH box4

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Phylogenomic databases

InParanoidiP87114
KOiK14439
OrthoDBiEOG092C0RAA
PhylomeDBiP87114

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

P87114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRKDNKELI CIPSSSPPST PIREENYYLL TSSPIECSPI QQLDLSGSFK
60 70 80 90 100
NYSTTSSRAN GKKFGQLAMQ SRIFFDTTDH KKYVESSYAA YDPHDQPPER
110 120 130 140 150
DVSLKESSNK INPSNFFDSE QITKINAVKK RFPALDSEMI IATLEKFNWR
160 170 180 190 200
ENITIHKLTF QKLLGRGNST INKSAQKLNN QPIEKSSVDK ENAKRKRYVE
210 220 230 240 250
EGTKQGQKKK PLRVIELSDE ETNEDDLLGQ SPTACTTDAN IDNSIPENSD
260 270 280 290 300
KIEEVSIESS GPSEVEDEMS EYDVRVLNFL NESTLQEIVE VSGCESKVVE
310 320 330 340 350
YFISKRPFPS LEKAEALCQR NAHAATGKRK KSDGRNVGRK LVNSTYEVLQ
360 370 380 390 400
GFDAVDSLIA KCERYGAMIS NTMRSWHNLF DDKKMEQFLN TSTGSISYEY
410 420 430 440 450
NSQQPSSIAS GITLKSYQIV GLNWLCLMYK AKLSGILADE MGLGKTCQVI
460 470 480 490 500
SFLASLKEKG IQNRHLVVVP SSTLGNWLRE FEKFCPSLRV ESYSGTQSER
510 520 530 540 550
INKRYYLMDT DFDVLVTTYQ LASGSRDDRS FLRKQRFDIS IFDEGHYLKN
560 570 580 590 600
RMSERYKHLM NIPANFRLLI TGTPLQNNLK ELISLLAFML PKVFDNNMQG
610 620 630 640 650
LDIIYKIKTT SDGDIERAYL SQERISRAKT IMNPFILRRR KENVLSDLPP
660 670 680 690 700
KIQHVEYCHM EETQLSLYLS VLELKNLVNA NRENILMQLR KAALHQLLFR
710 720 730 740 750
SQYNLETLSL MSKRILREDA YLDANPQYIF EDMEVMSDFE LHKLADQYRH
760 770 780 790 800
LHPFALKGKP WMDSAKVKKL CSLLKKSRPN ERILIFSQFT QVLDILEYVL
810 820 830 840 850
NTLDLEFLRL DGSTPVETRQ QLIDDFHTNE NYKVFLLSTK SGGFGINLTC
860 870 880 890 900
ANIVILFDCS FNPFDDMQAE DRAHRVGQTR PVHVYRLITK NTIEENIRRL
910 920 930 940
ANTKLTLESS LTTDSEKIQK EISGELMKSL QMDGRVDTMD GSVV
Length:944
Mass (Da):108,252
Last modified:July 1, 1997 - v1
Checksum:i23A17A57C31F5E83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB08602.1
PIRiT38130
RefSeqiNP_593325.1, NM_001018756.2

Genome annotation databases

EnsemblFungiiSPAC20G8.08c.1; SPAC20G8.08c.1:pep; SPAC20G8.08c
GeneIDi2541983
KEGGispo:SPAC20G8.08c

Similar proteinsi

Entry informationi

Entry nameiFFT1_SCHPO
AccessioniPrimary (citable) accession number: P87114
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 1, 1997
Last modified: April 25, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health