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Protein

Probable electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

Gene

SPAC20G8.04c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Accepts electrons from ETF and reduces ubiquinone.By similarity

Catalytic activityi

Reduced electron-transferring flavoprotein + ubiquinone = electron-transferring flavoprotein + ubiquinol.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi575 – 5751Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi601 – 6011Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi604 – 6041Iron-sulfur (4Fe-4S)Sequence analysis
Metal bindingi607 – 6071Iron-sulfur (4Fe-4S)Sequence analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi93 – 10715FADSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

4Fe-4S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Ubiquinone

Enzyme and pathway databases

ReactomeiR-SPO-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (EC:1.5.5.1)
Short name:
ETF-QO
Short name:
ETF-ubiquinone oxidoreductase
Alternative name(s):
Electron-transferring-flavoprotein dehydrogenase
Short name:
ETF dehydrogenase
Gene namesi
ORF Names:SPAC20G8.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC20G8.04c.
PomBaseiSPAC20G8.04c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 632Probable electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialPRO_0000008666
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiP87111.

Interactioni

Protein-protein interaction databases

BioGridi278470. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliP87111.
SMRiP87111. Positions 80-630.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini592 – 621304Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ETF-QO/FixC family.Curated
Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000259450.
InParanoidiP87111.
KOiK00311.
OMAiLRGMEPW.
OrthoDBiEOG71CFVN.
PhylomeDBiP87111.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR007859. ETFD_OxRdtase/FixX.
IPR023753. FAD/NAD-binding_dom.
[Graphical view]
PANTHERiPTHR10617:SF107. PTHR10617:SF107. 1 hit.
PfamiPF05187. ETF_QO. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
PROSITEiPS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P87111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYLSRSALA RSVGAKHLTG VLRKIGRRGG RSMHVLPLAS PSTLLKISSQ
60 70 80 90 100
TLRQDFTVLG ARNFHSSSVR LNELTDNLRK LDTIEREVED VDVCIVGAGP
110 120 130 140 150
AGLSAAIRIK QQAAKANRDI RVVVLEKAAE PGNHSVSGAV IQPTALDELL
160 170 180 190 200
PNWRDDPPEN CTAVTHDKMK FLIPKLHFPI PVPPAMKNHG NYVMSLAEFT
210 220 230 240 250
RWLAAKAEEY GVEIYPSFAA SEVLYNKDGS VIGVATNDFG VDSKGLPKDN
260 270 280 290 300
FERGMAFHAP VTLFAEGAHG SLSKSIIKRF NLRGNCEPQT YGLGVKEVWR
310 320 330 340 350
VPDENFRKGE VAHTLGWPMR NDTYGGGFMY QFGDNYVTVG LVVGLDYPNP
360 370 380 390 400
YVSPALEFQR MKQNPFFAKV LKGGKCLEYA ARALNEGGYQ AIPKLVFPGG
410 420 430 440 450
ALIGCSAGFV NVAKIKGTHT AMKSGIVAAD AIVDAFGRDA ASKPLLLNDY
460 470 480 490 500
EENLKNTYVF KELYSVRNIR PSFHSFLGNY GGMAYSAVEA YVLKGRVPWT
510 520 530 540 550
LKHKGGDAKA TKSASKYKPI NYPKPDNVLS FDIPTSVSRS ATMHAENQPC
560 570 580 590 600
HLFDHRPKDR KSCFETYKGV ENKFCPAGVY EYVNDEASSY GKRFVINSQN
610 620 630
CVHCKTCDIK DPLQGIQWKT PQGGDGPKYT LT
Length:632
Mass (Da):69,472
Last modified:July 1, 1997 - v1
Checksum:i1B0F22374E33771B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB08598.1.
PIRiT38126.
RefSeqiNP_593321.1. NM_001018752.2.

Genome annotation databases

EnsemblFungiiSPAC20G8.04c.1; SPAC20G8.04c.1:pep; SPAC20G8.04c.
GeneIDi2541985.
KEGGispo:SPAC20G8.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB08598.1.
PIRiT38126.
RefSeqiNP_593321.1. NM_001018752.2.

3D structure databases

ProteinModelPortaliP87111.
SMRiP87111. Positions 80-630.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278470. 5 interactions.

Proteomic databases

MaxQBiP87111.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC20G8.04c.1; SPAC20G8.04c.1:pep; SPAC20G8.04c.
GeneIDi2541985.
KEGGispo:SPAC20G8.04c.

Organism-specific databases

EuPathDBiFungiDB:SPAC20G8.04c.
PomBaseiSPAC20G8.04c.

Phylogenomic databases

HOGENOMiHOG000259450.
InParanoidiP87111.
KOiK00311.
OMAiLRGMEPW.
OrthoDBiEOG71CFVN.
PhylomeDBiP87111.

Enzyme and pathway databases

ReactomeiR-SPO-611105. Respiratory electron transport.

Miscellaneous databases

PROiP87111.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR007859. ETFD_OxRdtase/FixX.
IPR023753. FAD/NAD-binding_dom.
[Graphical view]
PANTHERiPTHR10617:SF107. PTHR10617:SF107. 1 hit.
PfamiPF05187. ETF_QO. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
PROSITEiPS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiETFD_SCHPO
AccessioniPrimary (citable) accession number: P87111
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.