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Protein

Myo-inositol transporter 2

Gene

itr2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transporter for myo-inositol.

GO - Molecular functioni

GO - Biological processi

  • glucose import Source: GO_Central
  • hexose transmembrane transport Source: GO_Central
  • myo-inositol import across plasma membrane Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-SPO-429593. Inositol transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Myo-inositol transporter 2
Gene namesi
Name:itr2
ORF Names:SPAC20G8.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC20G8.03.
PomBaseiSPAC20G8.03. itr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7676CytoplasmicSequence analysisAdd
BLAST
Transmembranei77 – 9721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini98 – 992ExtracellularSequence analysis
Transmembranei100 – 12021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini121 – 1233CytoplasmicSequence analysis
Transmembranei124 – 14421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini145 – 15713ExtracellularSequence analysisAdd
BLAST
Transmembranei158 – 17821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini179 – 1802CytoplasmicSequence analysis
Transmembranei181 – 20121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini202 – 2098ExtracellularSequence analysis
Transmembranei210 – 23021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini231 – 24010CytoplasmicSequence analysis
Transmembranei241 – 26121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini262 – 367106ExtracellularSequence analysisAdd
BLAST
Transmembranei368 – 38821Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini389 – 3968CytoplasmicSequence analysis
Transmembranei397 – 41721Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini418 – 43215ExtracellularSequence analysisAdd
BLAST
Transmembranei433 – 45321Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini454 – 46815CytoplasmicSequence analysisAdd
BLAST
Transmembranei469 – 48921Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini490 – 4989ExtracellularSequence analysis
Transmembranei499 – 51921Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini520 – 55738CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: PomBase
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Myo-inositol transporter 2PRO_0000050454Add
BLAST

Proteomic databases

MaxQBiP87110.

Interactioni

Protein-protein interaction databases

BioGridi278318. 1 interaction.
MINTiMINT-4692327.

Structurei

3D structure databases

ProteinModelPortaliP87110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000202868.
InParanoidiP87110.
KOiK08150.
OrthoDBiEOG7QG4D1.
PhylomeDBiP87110.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P87110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFNNIPLAT IKSSDDKGKD FIVEMTTRPS ETKKKVPFSE DMREIPSLPN
60 70 80 90 100
EEEANATDPQ ANEVADENGE GFEAEKISSW IWVLSAVAGI SGLLFGYDTG
110 120 130 140 150
VISGALAVLG SDLGHVLSSG QKELITSATS FAALISATTS GWLADWVGRK
160 170 180 190 200
RLLLCADAIF VIGSVIMAAS RNVAMMVVGR FIVGYGIGLT SLIVPMYITE
210 220 230 240 250
LAPARLRGRL VIIYVVFITG GQLIAYSLNA AFEHVHQGWR IMFGIGAAPA
260 270 280 290 300
LGQLISLFWT PESPRYLLRH NHVEKVYKIL SRIHPEAKPA EIAYKVSLIQ
310 320 330 340 350
EGVKVDFPEG NKFQHFFHSL KVLFTVPSNR RSLFIGCFLQ WFQQFSGTNA
360 370 380 390 400
IQYFSAIIFQ SVGFKNSISV SIVVGATNFV FTIVAFMFID RIGRRRILLC
410 420 430 440 450
TSAVMIAGLA LCAIAYHFLP ADTTQNTNSG WQYVVLASII IFLASYASGI
460 470 480 490 500
GNIPWQQAEL FPMEVRALGA GFSTAINWVG NLIISASFLT MMESITPTGT
510 520 530 540 550
FALFAGFCFV GLVTSYFTYP ELAGMSIENI HKLLEKGFWQ AVKESTKRVR

KGRIDEA
Length:557
Mass (Da):61,137
Last modified:July 1, 1997 - v1
Checksum:i20875EC11B153175
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti271 – 2711N → H in BAA13913 (PubMed:9501991).Curated
Sequence conflicti372 – 3721I → M in BAA13913 (PubMed:9501991).Curated
Sequence conflicti428 – 4281N → H in BAA13913 (PubMed:9501991).Curated
Sequence conflicti436 – 4361L → I in BAA13913 (PubMed:9501991).Curated
Sequence conflicti526 – 5261S → F in BAA13913 (PubMed:9501991).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99105 Genomic DNA. No translation available.
CU329670 Genomic DNA. Translation: CAB08597.1.
D89252 mRNA. Translation: BAA13913.1.
PIRiT38125.
T43176.
RefSeqiNP_593320.1. NM_001018751.2.

Genome annotation databases

EnsemblFungiiSPAC20G8.03.1; SPAC20G8.03.1:pep; SPAC20G8.03.
GeneIDi2541827.
KEGGispo:SPAC20G8.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99105 Genomic DNA. No translation available.
CU329670 Genomic DNA. Translation: CAB08597.1.
D89252 mRNA. Translation: BAA13913.1.
PIRiT38125.
T43176.
RefSeqiNP_593320.1. NM_001018751.2.

3D structure databases

ProteinModelPortaliP87110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278318. 1 interaction.
MINTiMINT-4692327.

Proteomic databases

MaxQBiP87110.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC20G8.03.1; SPAC20G8.03.1:pep; SPAC20G8.03.
GeneIDi2541827.
KEGGispo:SPAC20G8.03.

Organism-specific databases

EuPathDBiFungiDB:SPAC20G8.03.
PomBaseiSPAC20G8.03. itr2.

Phylogenomic databases

HOGENOMiHOG000202868.
InParanoidiP87110.
KOiK08150.
OrthoDBiEOG7QG4D1.
PhylomeDBiP87110.

Enzyme and pathway databases

ReactomeiR-SPO-429593. Inositol transporters.

Miscellaneous databases

PROiP87110.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Exogenous inositol and genes responsible for inositol transport are required for mating and sporulation in Shizosaccharomyces pombe."
    Niederberger C., Graub R., Schweingruber A.-M., Fankhauser H., Rusu M., Poitelea M., Edenharter L., Schweingruber M.E.
    Curr. Genet. 33:255-261(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 38364 / 968.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 166-541.
    Strain: PR745.

Entry informationi

Entry nameiITR2_SCHPO
AccessioniPrimary (citable) accession number: P87110
Secondary accession number(s): P78901
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.