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Protein

Myo-inositol transporter 2

Gene

itr2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transporter for myo-inositol.

GO - Molecular functioni

GO - Biological processi

  • glucose import Source: GO_Central
  • hexose transmembrane transport Source: GO_Central
  • myo-inositol import across plasma membrane Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-SPO-429593. Inositol transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Myo-inositol transporter 2
Gene namesi
Name:itr2
ORF Names:SPAC20G8.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC20G8.03.
PomBaseiSPAC20G8.03. itr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 76CytoplasmicSequence analysisAdd BLAST76
Transmembranei77 – 97Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini98 – 99ExtracellularSequence analysis2
Transmembranei100 – 120Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini121 – 123CytoplasmicSequence analysis3
Transmembranei124 – 144Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini145 – 157ExtracellularSequence analysisAdd BLAST13
Transmembranei158 – 178Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini179 – 180CytoplasmicSequence analysis2
Transmembranei181 – 201Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini202 – 209ExtracellularSequence analysis8
Transmembranei210 – 230Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini231 – 240CytoplasmicSequence analysis10
Transmembranei241 – 261Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini262 – 367ExtracellularSequence analysisAdd BLAST106
Transmembranei368 – 388Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini389 – 396CytoplasmicSequence analysis8
Transmembranei397 – 417Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini418 – 432ExtracellularSequence analysisAdd BLAST15
Transmembranei433 – 453Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini454 – 468CytoplasmicSequence analysisAdd BLAST15
Transmembranei469 – 489Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini490 – 498ExtracellularSequence analysis9
Transmembranei499 – 519Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini520 – 557CytoplasmicSequence analysisAdd BLAST38

GO - Cellular componenti

  • endoplasmic reticulum Source: PomBase
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504541 – 557Myo-inositol transporter 2Add BLAST557

Proteomic databases

MaxQBiP87110.
PRIDEiP87110.

Interactioni

Protein-protein interaction databases

BioGridi278318. 1 interactor.
MINTiMINT-4692327.

Structurei

3D structure databases

ProteinModelPortaliP87110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000202868.
InParanoidiP87110.
KOiK08150.
OrthoDBiEOG092C305R.
PhylomeDBiP87110.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P87110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFNNIPLAT IKSSDDKGKD FIVEMTTRPS ETKKKVPFSE DMREIPSLPN
60 70 80 90 100
EEEANATDPQ ANEVADENGE GFEAEKISSW IWVLSAVAGI SGLLFGYDTG
110 120 130 140 150
VISGALAVLG SDLGHVLSSG QKELITSATS FAALISATTS GWLADWVGRK
160 170 180 190 200
RLLLCADAIF VIGSVIMAAS RNVAMMVVGR FIVGYGIGLT SLIVPMYITE
210 220 230 240 250
LAPARLRGRL VIIYVVFITG GQLIAYSLNA AFEHVHQGWR IMFGIGAAPA
260 270 280 290 300
LGQLISLFWT PESPRYLLRH NHVEKVYKIL SRIHPEAKPA EIAYKVSLIQ
310 320 330 340 350
EGVKVDFPEG NKFQHFFHSL KVLFTVPSNR RSLFIGCFLQ WFQQFSGTNA
360 370 380 390 400
IQYFSAIIFQ SVGFKNSISV SIVVGATNFV FTIVAFMFID RIGRRRILLC
410 420 430 440 450
TSAVMIAGLA LCAIAYHFLP ADTTQNTNSG WQYVVLASII IFLASYASGI
460 470 480 490 500
GNIPWQQAEL FPMEVRALGA GFSTAINWVG NLIISASFLT MMESITPTGT
510 520 530 540 550
FALFAGFCFV GLVTSYFTYP ELAGMSIENI HKLLEKGFWQ AVKESTKRVR

KGRIDEA
Length:557
Mass (Da):61,137
Last modified:July 1, 1997 - v1
Checksum:i20875EC11B153175
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti271N → H in BAA13913 (PubMed:9501991).Curated1
Sequence conflicti372I → M in BAA13913 (PubMed:9501991).Curated1
Sequence conflicti428N → H in BAA13913 (PubMed:9501991).Curated1
Sequence conflicti436L → I in BAA13913 (PubMed:9501991).Curated1
Sequence conflicti526S → F in BAA13913 (PubMed:9501991).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99105 Genomic DNA. No translation available.
CU329670 Genomic DNA. Translation: CAB08597.1.
D89252 mRNA. Translation: BAA13913.1.
PIRiT38125.
T43176.
RefSeqiNP_593320.1. NM_001018751.2.

Genome annotation databases

EnsemblFungiiSPAC20G8.03.1; SPAC20G8.03.1:pep; SPAC20G8.03.
GeneIDi2541827.
KEGGispo:SPAC20G8.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99105 Genomic DNA. No translation available.
CU329670 Genomic DNA. Translation: CAB08597.1.
D89252 mRNA. Translation: BAA13913.1.
PIRiT38125.
T43176.
RefSeqiNP_593320.1. NM_001018751.2.

3D structure databases

ProteinModelPortaliP87110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278318. 1 interactor.
MINTiMINT-4692327.

Proteomic databases

MaxQBiP87110.
PRIDEiP87110.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC20G8.03.1; SPAC20G8.03.1:pep; SPAC20G8.03.
GeneIDi2541827.
KEGGispo:SPAC20G8.03.

Organism-specific databases

EuPathDBiFungiDB:SPAC20G8.03.
PomBaseiSPAC20G8.03. itr2.

Phylogenomic databases

HOGENOMiHOG000202868.
InParanoidiP87110.
KOiK08150.
OrthoDBiEOG092C305R.
PhylomeDBiP87110.

Enzyme and pathway databases

ReactomeiR-SPO-429593. Inositol transporters.

Miscellaneous databases

PROiP87110.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITR2_SCHPO
AccessioniPrimary (citable) accession number: P87110
Secondary accession number(s): P78901
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.