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P87076 (BGLA_ASPKW) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-glucosidase A

EC=3.2.1.21
Alternative name(s):
Beta-D-glucoside glucohydrolase A
Cellobiase A
Gentiobiase A
Gene names
Name:bglA
Synonyms:bgl1
ORF Names:AKAW_01481
OrganismAspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus awamori var. kawachi) [Complete proteome]
Taxonomic identifier1033177 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length860 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose. Ref.1

Catalytic activity

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathway

Glycan metabolism; cellulose degradation.

Subcellular location

Secreted Probable Ref.1.

Sequence similarities

Belongs to the glycosyl hydrolase 3 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Cellulose degradation
Polysaccharide degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological_processcellulose catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-glucosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 860841Beta-glucosidase A
PRO_0000394096

Sites

Active site2801 By similarity

Amino acid modifications

Glycosylation611N-linked (GlcNAc...) Potential
Glycosylation2111N-linked (GlcNAc...) Potential
Glycosylation2521N-linked (GlcNAc...) Potential
Glycosylation3151N-linked (GlcNAc...) Potential
Glycosylation3221N-linked (GlcNAc...) Potential
Glycosylation3541N-linked (GlcNAc...) Potential
Glycosylation3871N-linked (GlcNAc...) Potential
Glycosylation4421N-linked (GlcNAc...) Potential
Glycosylation5231N-linked (GlcNAc...) Potential
Glycosylation5421N-linked (GlcNAc...) Potential
Glycosylation5641N-linked (GlcNAc...) Potential
Glycosylation6581N-linked (GlcNAc...) Potential
Glycosylation6901N-linked (GlcNAc...) Potential
Glycosylation7121N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict5221R → K in BAA19913. Ref.1
Sequence conflict8501L → P in BAA19913. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P87076 [UniParc].

Last modified March 21, 2012. Version 2.
Checksum: DA0FEF8C42CDBA37

FASTA86093,349
        10         20         30         40         50         60 
MRFTLIEAVA LTAVSLASAD ELAYSPPYYP SPWANGQGDW AQAYQRAVDI VSQMTLAEKV 

        70         80         90        100        110        120 
NLTTGTGWEL ELCVGQTGGV PRLGVPGMCL QDSPLGVRDS DYNSAFPSGM NVAATWDKNL 

       130        140        150        160        170        180 
AYLRGKAMGQ EFSDKGADIQ LGPAAGPLGR SPDGGRNWEG FSPDPALSGV LFAETIKGIQ 

       190        200        210        220        230        240 
DAGVVATAKH YIAYEQEHFR QAPEAQGYGF NISESGSANL DDKTMHELYL WPFADAIRAG 

       250        260        270        280        290        300 
AGAVMCSYNQ INNSYGCQNS YTLNKLLKAE LGFQGFVMSD WAAHHAGVSG ALAGLDMSMP 

       310        320        330        340        350        360 
GDVDYDSGTS YWGTNLTVSV LNGTVPQWRV DDMAVRIMAA YYKVGRDRLW TPPNFSSWTR 

       370        380        390        400        410        420 
DEYGYKYYYV SEGPYEKVNH YVNVQRNHSE LIRRIGADST VLLKNDGALP LTGKERLVAL 

       430        440        450        460        470        480 
IGEDAGSNPY GANGCSDRGC DNGTLAMGWG SGTANFPYLV TPEQAISNEV LKNKNGVFTA 

       490        500        510        520        530        540 
TDNWAIDQIE ALAKTASVSL VFVNADSGEG YINVDGNLGD RRNLTLWRNG DNVIKAAASN 

       550        560        570        580        590        600 
CNNTIVIIHS VGPVLVNEWY DNPNVTAILW GGLPGQESGN SLADVLYGRV NPGAKSPFTW 

       610        620        630        640        650        660 
GKTREAYQDY LVTEPNNGNG APQEDFVEGV FIDYRGFDKR NETPIYEFGY GLSYTTFNYS 

       670        680        690        700        710        720 
NLEVQVLSAP AYEPASGETE AAPTFGEVGN ASNYLYPDGL QKITKFIYPW LNSTDLEASS 

       730        740        750        760        770        780 
GDASYGQDSS DYLPEGATDG SAQPILPAGG GPGGNPRLYD ELIRVSVTIK NTGKVAGDEV 

       790        800        810        820        830        840 
PQLYVSLGGP NEPKIVLRQF ERITLQPSEE TKWSTTLTRR DLANWNVEKQ DWEITSYPKM 

       850        860 
VFVGSSSRKL PLRASLPTVH 

« Hide

References

« Hide 'large scale' references
[1]"The bglA gene of Aspergillus kawachii encodes both extracellular and cell wall-bound beta-glucosidases."
Iwashita K., Nagahara T., Kimura H., Takano M., Shimoi H., Ito K.
Appl. Environ. Microbiol. 65:5546-5553(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 178-189; 405-414 AND 603-618, SUBCELLULAR LOCATION, FUNCTION.
Strain: NBRC 4308.
[2]"Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used for brewing the Japanese distilled spirit shochu."
Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., Takashita H., Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.
Eukaryot. Cell 10:1586-1587(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NBRC 4308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB003470 Genomic DNA. Translation: BAA19913.1.
DF126449 Genomic DNA. Translation: GAA83366.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH3. Glycoside Hydrolase Family 3.
mycoCLAPBGL3A1_ASPKA.
BGL3A2_ASPKA.
BGL3A3_ASPKA.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG7HMS8F.

Enzyme and pathway databases

UniPathwayUPA00696.

Family and domain databases

Gene3D3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR019800. Glyco_hydro_3_AS.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR30620. PTHR30620. 1 hit.
PfamPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSPR00133. GLHYDRLASE3.
SUPFAMSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
PROSITEPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBGLA_ASPKW
AccessionPrimary (citable) accession number: P87076
Secondary accession number(s): G7X8K7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: March 21, 2012
Last modified: November 13, 2013
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries