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P87076

- BGLA_ASPKW

UniProt

P87076 - BGLA_ASPKW

Protein

Beta-glucosidase A

Gene

bglA

Organism
Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus awamori var. kawachi)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 2 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.1 Publication

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei280 – 2801By similarity

    GO - Molecular functioni

    1. beta-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Enzyme and pathway databases

    UniPathwayiUPA00696.

    Protein family/group databases

    CAZyiGH3. Glycoside Hydrolase Family 3.
    mycoCLAPiBGL3A1_ASPKA.
    BGL3A2_ASPKA.
    BGL3A3_ASPKA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-glucosidase A (EC:3.2.1.21)
    Alternative name(s):
    Beta-D-glucoside glucohydrolase A
    Cellobiase A
    Gentiobiase A
    Gene namesi
    Name:bglA
    Synonyms:bgl1
    ORF Names:AKAW_01481
    OrganismiAspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus awamori var. kawachi)
    Taxonomic identifieri1033177 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006812: Unassembled WGS sequence

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 860841Beta-glucosidase APRO_0000394096Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi322 – 3221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi354 – 3541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi442 – 4421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi523 – 5231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi542 – 5421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi564 – 5641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi658 – 6581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi690 – 6901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi712 – 7121N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 3 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OrthoDBiEOG7HMS8F.

    Family and domain databases

    Gene3Di3.20.20.300. 1 hit.
    3.40.50.1700. 1 hit.
    InterProiIPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR019800. Glyco_hydro_3_AS.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR30620. PTHR30620. 1 hit.
    PfamiPF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    [Graphical view]
    PRINTSiPR00133. GLHYDRLASE3.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 2 hits.
    PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P87076-1 [UniParc]FASTAAdd to Basket

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    MRFTLIEAVA LTAVSLASAD ELAYSPPYYP SPWANGQGDW AQAYQRAVDI    50
    VSQMTLAEKV NLTTGTGWEL ELCVGQTGGV PRLGVPGMCL QDSPLGVRDS 100
    DYNSAFPSGM NVAATWDKNL AYLRGKAMGQ EFSDKGADIQ LGPAAGPLGR 150
    SPDGGRNWEG FSPDPALSGV LFAETIKGIQ DAGVVATAKH YIAYEQEHFR 200
    QAPEAQGYGF NISESGSANL DDKTMHELYL WPFADAIRAG AGAVMCSYNQ 250
    INNSYGCQNS YTLNKLLKAE LGFQGFVMSD WAAHHAGVSG ALAGLDMSMP 300
    GDVDYDSGTS YWGTNLTVSV LNGTVPQWRV DDMAVRIMAA YYKVGRDRLW 350
    TPPNFSSWTR DEYGYKYYYV SEGPYEKVNH YVNVQRNHSE LIRRIGADST 400
    VLLKNDGALP LTGKERLVAL IGEDAGSNPY GANGCSDRGC DNGTLAMGWG 450
    SGTANFPYLV TPEQAISNEV LKNKNGVFTA TDNWAIDQIE ALAKTASVSL 500
    VFVNADSGEG YINVDGNLGD RRNLTLWRNG DNVIKAAASN CNNTIVIIHS 550
    VGPVLVNEWY DNPNVTAILW GGLPGQESGN SLADVLYGRV NPGAKSPFTW 600
    GKTREAYQDY LVTEPNNGNG APQEDFVEGV FIDYRGFDKR NETPIYEFGY 650
    GLSYTTFNYS NLEVQVLSAP AYEPASGETE AAPTFGEVGN ASNYLYPDGL 700
    QKITKFIYPW LNSTDLEASS GDASYGQDSS DYLPEGATDG SAQPILPAGG 750
    GPGGNPRLYD ELIRVSVTIK NTGKVAGDEV PQLYVSLGGP NEPKIVLRQF 800
    ERITLQPSEE TKWSTTLTRR DLANWNVEKQ DWEITSYPKM VFVGSSSRKL 850
    PLRASLPTVH 860
    Length:860
    Mass (Da):93,349
    Last modified:March 21, 2012 - v2
    Checksum:iDA0FEF8C42CDBA37
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti522 – 5221R → K in BAA19913. (PubMed:10584016)Curated
    Sequence conflicti850 – 8501L → P in BAA19913. (PubMed:10584016)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB003470 Genomic DNA. Translation: BAA19913.1.
    DF126449 Genomic DNA. Translation: GAA83366.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB003470 Genomic DNA. Translation: BAA19913.1 .
    DF126449 Genomic DNA. Translation: GAA83366.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH3. Glycoside Hydrolase Family 3.
    mycoCLAPi BGL3A1_ASPKA.
    BGL3A2_ASPKA.
    BGL3A3_ASPKA.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG7HMS8F.

    Enzyme and pathway databases

    UniPathwayi UPA00696 .

    Family and domain databases

    Gene3Di 3.20.20.300. 1 hit.
    3.40.50.1700. 1 hit.
    InterProi IPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR019800. Glyco_hydro_3_AS.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR30620. PTHR30620. 1 hit.
    Pfami PF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00133. GLHYDRLASE3.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 2 hits.
    PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The bglA gene of Aspergillus kawachii encodes both extracellular and cell wall-bound beta-glucosidases."
      Iwashita K., Nagahara T., Kimura H., Takano M., Shimoi H., Ito K.
      Appl. Environ. Microbiol. 65:5546-5553(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 178-189; 405-414 AND 603-618, SUBCELLULAR LOCATION, FUNCTION.
      Strain: NBRC 4308.
    2. "Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used for brewing the Japanese distilled spirit shochu."
      Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., Takashita H., Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.
      Eukaryot. Cell 10:1586-1587(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NBRC 4308.

    Entry informationi

    Entry nameiBGLA_ASPKW
    AccessioniPrimary (citable) accession number: P87076
    Secondary accession number(s): G7X8K7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 18, 2010
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 57 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3