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Protein

WD repeat-containing protein pop1

Gene

pop1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in maintenance of ploidy through proteasome dependent degradation of CDK inhibitor rum1 and S-phase initiator cdc18. Functions as a recognition factor for rum1 and cdc18, which are subsequently ubiquitinated and targeted to the 26S proteasome for degradation. Together with pop2, required for cig2 instability during G2 and M phase and cig2 degradation in exponentially growing cells. Regulates cell-cycle progression under starvation through the rum1 protein.4 Publications

GO - Molecular functioni

  • protein binding, bridging Source: PomBase

GO - Biological processi

  • anaphase-promoting complex-dependent catabolic process Source: PomBase
  • conjugation with cellular fusion Source: PomBase
  • ubiquitin-dependent protein catabolic process Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein pop1
Alternative name(s):
WD repeat-containing protein ste16
Gene namesi
Name:pop1
Synonyms:ste16
ORF Names:SPBC1718.01, SPBC2G2.18
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1718.01.
PomBaseiSPBC1718.01. pop1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: PomBase
  • SCF ubiquitin ligase complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511391 – 775WD repeat-containing protein pop1Add BLAST775

Proteomic databases

MaxQBiP87060.
PRIDEiP87060.

Interactioni

Subunit structurei

Homodimer and heterodimer with pop2. Binds to cdc18, phosphorylated cig2, cul1, pip1 and skp1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
cdc18P414113EBI-1185389,EBI-1207853
cig2P366304EBI-1185389,EBI-1149212
pop2O1417012EBI-1185389,EBI-1185414
skp1Q9Y7092EBI-1185389,EBI-1172248

GO - Molecular functioni

  • protein binding, bridging Source: PomBase

Protein-protein interaction databases

BioGridi277039. 11 interactors.
IntActiP87060. 7 interactors.
MINTiMINT-4692278.

Structurei

3D structure databases

ProteinModelPortaliP87060.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini298 – 345F-boxPROSITE-ProRule annotationAdd BLAST48
Repeati444 – 472WD 1Add BLAST29
Repeati484 – 538WD 2Add BLAST55
Repeati575 – 603WD 3Add BLAST29
Repeati615 – 645WD 4Add BLAST31
Repeati657 – 687WD 5Add BLAST31

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

InParanoidiP87060.
KOiK03361.
OMAiWIDHENE.
OrthoDBiEOG092C10HM.
PhylomeDBiP87060.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00256. FBOX. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P87060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEKKKDSLS VLDSNEFFGE TTMVSPSIDV SSSPRPNVER FSPCSTKKDL
60 70 80 90 100
LEGNNIMTRI PEELSRVSLQ FDSKGSQQSM IFTNNRCLSD KENLENLQNL
110 120 130 140 150
LYLHCDLNRP HLSCELPSEH REKCLKRRNS SLSSNLHANK RFLFNSQSDG
160 170 180 190 200
NKKNETFPST NYSNVFYPNN CDSKEVASET TFSLDAPNNS VNYSYFSPNL
210 220 230 240 250
LGNDSKTRQS FPPHSSSSSH NSLHEPVIYD FSSENPSIHP SNHLSSQKNA
260 270 280 290 300
VLKLAQLISS FEKLPESVRQ YLLFHLLSRC GKHAVQNIHK ILLPIFQKNF
310 320 330 340 350
LTGFPAEITN LVLTHLDAPS LCAVSQVSHH WYKLVSSNEE LWKSLFLKDG
360 370 380 390 400
FFWDSIDSKI RTMCLEQSLS ACAIMKRVYF RHFNLRERWL HAPEKIKRCS
410 420 430 440 450
FPIHGVRLIT KLQFDDDKII VSTCSPRINI YDTKTGVLIR SLEEHEGDVW
460 470 480 490 500
TFEYVGDTLV TGSTDRTVRV WDLRTGECKQ VFYGHTSTIR CIKIVQGNQS
510 520 530 540 550
TTDTDDVEKE NRPASNDANS MPPYIISSSR DCTIRLWSLP CLDDPPFVNV
560 570 580 590 600
NENPDQNNDF TSATTNPFYI RTLRGHTDSV REVACLGDLI VSASYDGTLR
610 620 630 640 650
VWKASTGVCL HVLRGHVGRV YSVTINPSRQ QCISAGTDAK IRIWNLESGE
660 670 680 690 700
LLQTLHGHSN LVSQVTFNQN ILVSASAPPD TSLRVWDLNT GSCRDILKCP
710 720 730 740 750
LGHIFFQHDE SKVVSGSHST LQLWDIRSGK LVRDLLTDLD IIWQVAYNEN
760 770
VCVAAVLRNN RFWIEVLEFG STKSS
Length:775
Mass (Da):87,817
Last modified:July 1, 1997 - v1
Checksum:iB06EDBA46553EEC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08391 Genomic DNA. Translation: CAA69671.1.
CU329671 Genomic DNA. Translation: CAB75991.1.
PIRiT45136.
T50329.
RefSeqiXP_001713146.1. XM_001713094.2.

Genome annotation databases

EnsemblFungiiSPBC1718.01.1; SPBC1718.01.1:pep; SPBC1718.01.
GeneIDi2540511.
KEGGispo:SPBC1718.01.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08391 Genomic DNA. Translation: CAA69671.1.
CU329671 Genomic DNA. Translation: CAB75991.1.
PIRiT45136.
T50329.
RefSeqiXP_001713146.1. XM_001713094.2.

3D structure databases

ProteinModelPortaliP87060.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277039. 11 interactors.
IntActiP87060. 7 interactors.
MINTiMINT-4692278.

Proteomic databases

MaxQBiP87060.
PRIDEiP87060.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1718.01.1; SPBC1718.01.1:pep; SPBC1718.01.
GeneIDi2540511.
KEGGispo:SPBC1718.01.

Organism-specific databases

EuPathDBiFungiDB:SPBC1718.01.
PomBaseiSPBC1718.01. pop1.

Phylogenomic databases

InParanoidiP87060.
KOiK03361.
OMAiWIDHENE.
OrthoDBiEOG092C10HM.
PhylomeDBiP87060.

Enzyme and pathway databases

ReactomeiR-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiP87060.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00256. FBOX. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPOP1_SCHPO
AccessioniPrimary (citable) accession number: P87060
Secondary accession number(s): Q9P7P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: November 30, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.