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Protein

La protein homolog

Gene

sla1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the precursors of polymerase III RNAs. Functions in tRNA maturation.

GO - Molecular functioni

GO - Biological processi

  • termination of RNA polymerase III transcription Source: PomBase
  • tRNA 3'-trailer cleavage Source: PomBase
  • tRNA 3'-trailer cleavage, endonucleolytic Source: PomBase
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
La protein homolog
Alternative name(s):
La autoantigen homolog
La ribonucleoprotein
Gene namesi
Name:sla1
Synonyms:lah1
ORF Names:SPAC57A10.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC57A10.10c.
PomBaseiSPAC57A10.10c. sla1.

Subcellular locationi

GO - Cellular componenti

  • intracellular ribonucleoprotein complex Source: InterPro
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298La protein homologPRO_0000207607Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611Phosphoserine1 Publication
Modified residuei124 – 1241Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP87058.

PTM databases

iPTMnetiP87058.

Interactioni

Protein-protein interaction databases

BioGridi278030. 22 interactions.
MINTiMINT-4692249.

Structurei

3D structure databases

ProteinModelPortaliP87058.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 14892HTH La-type RNA-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini154 – 23683RRMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH La-type RNA-binding domain.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000113277.
KOiK11090.
OMAiHEIRSIY.
PhylomeDBiP87058.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PRINTSiPR00302. LUPUSLA.
SMARTiSM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P87058-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTEEQKEEI KDISSKQENS SEVPKAEEAG KVVESQKDTT SEEKKEETTE
60 70 80 90 100
KKEDDGKKDL SFDEAEVLKQ VEFYFSDTNL PHDKFLWTTS QKNDGWVPIQ
110 120 130 140 150
TIANFKRMRR FQPLEAIVNA LRKSPELLEV DEAGEKVRRM IPLVRVDNKS
160 170 180 190 200
VMERSVYCKG FGDEKDDTQI ALEKFFEENA GPISAVRMRR DDDKKFKGSV
210 220 230 240 250
FVEFKEPDVA NKFLEKVKTA PLKWGEDELT IMSKKEYVDM KAELHKNDPP
260 270 280 290
KFSSKRRRFD AFKEMDRQRP GKYSNRGRKF KKQRSSNASE EKPSAASE
Length:298
Mass (Da):34,616
Last modified:July 1, 1997 - v1
Checksum:i64E6AB99940B87F4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti188 – 1881M → I (PubMed:9404894).Curated
Sequence conflicti188 – 1881M → I (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022949 mRNA. Translation: AAB82145.1.
AB011371 mRNA. Translation: BAA24981.1.
CU329670 Genomic DNA. Translation: CAB08173.1.
PIRiT38937.
T43542.
RefSeqiNP_593315.1. NM_001018746.2.

Genome annotation databases

EnsemblFungiiSPAC57A10.10c.1; SPAC57A10.10c.1:pep; SPAC57A10.10c.
GeneIDi2541530.
KEGGispo:SPAC57A10.10c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022949 mRNA. Translation: AAB82145.1.
AB011371 mRNA. Translation: BAA24981.1.
CU329670 Genomic DNA. Translation: CAB08173.1.
PIRiT38937.
T43542.
RefSeqiNP_593315.1. NM_001018746.2.

3D structure databases

ProteinModelPortaliP87058.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278030. 22 interactions.
MINTiMINT-4692249.

PTM databases

iPTMnetiP87058.

Proteomic databases

MaxQBiP87058.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC57A10.10c.1; SPAC57A10.10c.1:pep; SPAC57A10.10c.
GeneIDi2541530.
KEGGispo:SPAC57A10.10c.

Organism-specific databases

EuPathDBiFungiDB:SPAC57A10.10c.
PomBaseiSPAC57A10.10c. sla1.

Phylogenomic databases

HOGENOMiHOG000113277.
KOiK11090.
OMAiHEIRSIY.
PhylomeDBiP87058.

Miscellaneous databases

PROiP87058.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PRINTSiPR00302. LUPUSLA.
SMARTiSM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The La protein in Schizosaccharomyces pombe: a conserved yet dispensable phosphoprotein that functions in tRNA maturation."
    van Horn D.J., Yoo C.J., Xue D., Shi H., Wolin S.L.
    RNA 3:1434-1443(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Screening of S. pombe cDNA library using E. coli defective in signal transduction: cloning and DNA sequence of La-like protein (SLA1)."
    Utsumi R.R.U.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61 AND SER-124, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiLAH1_SCHPO
AccessioniPrimary (citable) accession number: P87058
Secondary accession number(s): O13362, Q10458
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: June 8, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.