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Protein

La protein homolog

Gene

sla1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the precursors of polymerase III RNAs. Functions in tRNA maturation.

GO - Molecular functioni

  • RNA strand annealing activity Source: PomBase
  • tRNA binding Source: PomBase

GO - Biological processi

  • termination of RNA polymerase III transcription Source: PomBase
  • tRNA 3'-end processing Source: CAFA
  • tRNA 3'-trailer cleavage Source: PomBase
  • tRNA 3'-trailer cleavage, endonucleolytic Source: PomBase
  • tRNA 5'-leader removal Source: CAFA
  • tRNA export from nucleus Source: CAFA
  • tRNA folding Source: PomBase
  • tRNA processing Source: CAFA

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
La protein homolog
Alternative name(s):
La autoantigen homolog
La ribonucleoprotein
Gene namesi
Name:sla1
Synonyms:lah1
ORF Names:SPAC57A10.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC57A10.10c
PomBaseiSPAC57A10.10c sla1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002076071 – 298La protein homologAdd BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61Phosphoserine1 Publication1
Modified residuei124Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP87058
PaxDbiP87058
PRIDEiP87058

PTM databases

iPTMnetiP87058

Interactioni

Protein-protein interaction databases

BioGridi278030, 22 interactors
STRINGi4896.SPAC57A10.10c.1

Structurei

3D structure databases

ProteinModelPortaliP87058
SMRiP87058
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 148HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST92
Domaini154 – 236RRMPROSITE-ProRule annotationAdd BLAST83

Phylogenomic databases

HOGENOMiHOG000113277
KOiK11090
OMAiNDGWVEL
OrthoDBiEOG092C4I3J
PhylomeDBiP87058

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006630 La_HTH
IPR002344 Lupus_La
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF05383 La, 1 hit
PF00076 RRM_1, 1 hit
PRINTSiPR00302 LUPUSLA
SMARTiView protein in SMART
SM00715 LA, 1 hit
SM00360 RRM, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50961 HTH_LA, 1 hit
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

P87058-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTEEQKEEI KDISSKQENS SEVPKAEEAG KVVESQKDTT SEEKKEETTE
60 70 80 90 100
KKEDDGKKDL SFDEAEVLKQ VEFYFSDTNL PHDKFLWTTS QKNDGWVPIQ
110 120 130 140 150
TIANFKRMRR FQPLEAIVNA LRKSPELLEV DEAGEKVRRM IPLVRVDNKS
160 170 180 190 200
VMERSVYCKG FGDEKDDTQI ALEKFFEENA GPISAVRMRR DDDKKFKGSV
210 220 230 240 250
FVEFKEPDVA NKFLEKVKTA PLKWGEDELT IMSKKEYVDM KAELHKNDPP
260 270 280 290
KFSSKRRRFD AFKEMDRQRP GKYSNRGRKF KKQRSSNASE EKPSAASE
Length:298
Mass (Da):34,616
Last modified:July 1, 1997 - v1
Checksum:i64E6AB99940B87F4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188M → I (PubMed:9404894).Curated1
Sequence conflicti188M → I (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022949 mRNA Translation: AAB82145.1
AB011371 mRNA Translation: BAA24981.1
CU329670 Genomic DNA Translation: CAB08173.1
PIRiT38937
T43542
RefSeqiNP_593315.1, NM_001018746.2

Genome annotation databases

EnsemblFungiiSPAC57A10.10c.1; SPAC57A10.10c.1:pep; SPAC57A10.10c
GeneIDi2541530
KEGGispo:SPAC57A10.10c

Similar proteinsi

Entry informationi

Entry nameiLAH1_SCHPO
AccessioniPrimary (citable) accession number: P87058
Secondary accession number(s): O13362, Q10458
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

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