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Protein

Septum-promoting GTP-binding protein 1

Gene

spg1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTP-binding protein essential for the induction of septum formation at G2 and pre-START stages of mitosis. Acts via the cdc7 protein kinase pathway.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 24GTPBy similarity8
Nucleotide bindingi65 – 69GTPBy similarity5
Nucleotide bindingi122 – 125GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: PomBase

GO - Biological processi

  • cellular protein localization Source: PomBase
  • positive regulation of division septum assembly Source: PomBase
  • septation initiation signaling Source: PomBase

Keywordsi

Biological processCell cycle, Cell division, Mitosis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septum-promoting GTP-binding protein 1
Alternative name(s):
GTPase spg1
Sid3 protein
Gene namesi
Name:spg1
Synonyms:sid3
ORF Names:SPAC1565.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1565.06c.
PomBaseiSPAC1565.06c. spg1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224651 – 198Septum-promoting GTP-binding protein 1Add BLAST198

Proteomic databases

MaxQBiP87027.
PRIDEiP87027.

PTM databases

iPTMnetiP87027.

Interactioni

Subunit structurei

Interacts with cdc7 and cdc11.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
byr4Q109517EBI-1999803,EBI-1997311

Protein-protein interaction databases

BioGridi279211. 44 interactors.
IntActiP87027. 2 interactors.
MINTiMINT-4692114.
STRINGi4896.SPAC1565.06c.1.

Structurei

3D structure databases

ProteinModelPortaliP87027.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni6 – 198Small GTPase-likeAdd BLAST193

Phylogenomic databases

HOGENOMiHOG000216335.
InParanoidiP87027.
KOiK06682.
OMAiLKCVIPE.
OrthoDBiEOG092C4PMQ.
PhylomeDBiP87027.

Family and domain databases

CDDicd04128. Spg1. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR017231. Small_GTPase_Tem1/Spg1.
PANTHERiPTHR24073:SF875. PTHR24073:SF875. 1 hit.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
PIRSFiPIRSF037527. Small_GTPase_Tem1. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.

Sequencei

Sequence statusi: Complete.

P87027-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADARKNNVT IKVGMIGDSS IGKTSLMVTY VQGSFDEEST QTLGVNFMEK
60 70 80 90 100
TISIRNTEIT FSIWDLGGQR EFVNMLPMVC NDAVAILFMF DLSRKSTLNS
110 120 130 140 150
IKEWYRQARG FNKTAVPILI GTKYDHFMTF PREDQEEITK QARRYAKAMK
160 170 180 190
ASLVFCSTSH SINVQKIFKI VLAKVFDLKC TIPEIKNVGD PILEYIDR
Length:198
Mass (Da):22,543
Last modified:July 1, 1997 - v1
Checksum:iF9FFD08A5BF36316
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43L → LV in CAA04846 (PubMed:9649519).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12314 Genomic DNA. Translation: CAA72985.1.
AJ001587 Genomic DNA. Translation: CAA04846.1.
CU329670 Genomic DNA. Translation: CAB99273.1.
PIRiT45541.
RefSeqiNP_593285.1. NM_001018715.2.

Genome annotation databases

EnsemblFungiiSPAC1565.06c.1; SPAC1565.06c.1:pep; SPAC1565.06c.
GeneIDi2542761.
KEGGispo:SPAC1565.06c.

Similar proteinsi

Entry informationi

Entry nameiSPG1_SCHPO
AccessioniPrimary (citable) accession number: P87027
Secondary accession number(s): O14312
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: July 1, 1997
Last modified: November 22, 2017
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names