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Protein

Septum-promoting GTP-binding protein 1

Gene

spg1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTP-binding protein essential for the induction of septum formation at G2 and pre-START stages of mitosis. Acts via the cdc7 protein kinase pathway.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 24GTPBy similarity8
Nucleotide bindingi65 – 69GTPBy similarity5
Nucleotide bindingi122 – 125GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: PomBase
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • cellular protein localization Source: PomBase
  • mitotic nuclear division Source: UniProtKB-KW
  • positive regulation of barrier septum assembly Source: PomBase
  • septation initiation signaling Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septum-promoting GTP-binding protein 1
Alternative name(s):
GTPase spg1
Sid3 protein
Gene namesi
Name:spg1
Synonyms:sid3
ORF Names:SPAC1565.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1565.06c.
PomBaseiSPAC1565.06c. spg1.

Subcellular locationi

GO - Cellular componenti

  • mitotic spindle pole body Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224651 – 198Septum-promoting GTP-binding protein 1Add BLAST198

Proteomic databases

MaxQBiP87027.
PRIDEiP87027.

Interactioni

Subunit structurei

Interacts with cdc7 and cdc11.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
byr4Q109517EBI-1999803,EBI-1997311

Protein-protein interaction databases

BioGridi279211. 44 interactors.
IntActiP87027. 2 interactors.
MINTiMINT-4692114.

Structurei

3D structure databases

ProteinModelPortaliP87027.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni6 – 198Small GTPase-likeAdd BLAST193

Phylogenomic databases

HOGENOMiHOG000216335.
InParanoidiP87027.
KOiK06682.
OMAiEPILIYV.
OrthoDBiEOG092C4PMQ.
PhylomeDBiP87027.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P87027-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADARKNNVT IKVGMIGDSS IGKTSLMVTY VQGSFDEEST QTLGVNFMEK
60 70 80 90 100
TISIRNTEIT FSIWDLGGQR EFVNMLPMVC NDAVAILFMF DLSRKSTLNS
110 120 130 140 150
IKEWYRQARG FNKTAVPILI GTKYDHFMTF PREDQEEITK QARRYAKAMK
160 170 180 190
ASLVFCSTSH SINVQKIFKI VLAKVFDLKC TIPEIKNVGD PILEYIDR
Length:198
Mass (Da):22,543
Last modified:July 1, 1997 - v1
Checksum:iF9FFD08A5BF36316
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43L → LV in CAA04846 (PubMed:9649519).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12314 Genomic DNA. Translation: CAA72985.1.
AJ001587 Genomic DNA. Translation: CAA04846.1.
CU329670 Genomic DNA. Translation: CAB99273.1.
PIRiT45541.
RefSeqiNP_593285.1. NM_001018715.2.

Genome annotation databases

EnsemblFungiiSPAC1565.06c.1; SPAC1565.06c.1:pep; SPAC1565.06c.
GeneIDi2542761.
KEGGispo:SPAC1565.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12314 Genomic DNA. Translation: CAA72985.1.
AJ001587 Genomic DNA. Translation: CAA04846.1.
CU329670 Genomic DNA. Translation: CAB99273.1.
PIRiT45541.
RefSeqiNP_593285.1. NM_001018715.2.

3D structure databases

ProteinModelPortaliP87027.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279211. 44 interactors.
IntActiP87027. 2 interactors.
MINTiMINT-4692114.

Proteomic databases

MaxQBiP87027.
PRIDEiP87027.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1565.06c.1; SPAC1565.06c.1:pep; SPAC1565.06c.
GeneIDi2542761.
KEGGispo:SPAC1565.06c.

Organism-specific databases

EuPathDBiFungiDB:SPAC1565.06c.
PomBaseiSPAC1565.06c. spg1.

Phylogenomic databases

HOGENOMiHOG000216335.
InParanoidiP87027.
KOiK06682.
OMAiEPILIYV.
OrthoDBiEOG092C4PMQ.
PhylomeDBiP87027.

Miscellaneous databases

PROiP87027.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPG1_SCHPO
AccessioniPrimary (citable) accession number: P87027
Secondary accession number(s): O14312
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: July 1, 1997
Last modified: October 5, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.