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Protein

Trihydroxynaphthalene reductase

Gene

THR1

Organism
Colletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422) (Cucumber anthracnose fungus) (Colletotrichum lagenarium)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of 1,3,8-trihydroxynaphthalene (T3HN) into (-)-vermelone. Essential for appressorial penetration of colletotrichum lagenarium.

Pathwayi: melanin biosynthesis

This protein is involved in the pathway melanin biosynthesis, which is part of Pigment biosynthesis.
View all proteins of this organism that are known to be involved in the pathway melanin biosynthesis and in Pigment biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei164SubstrateBy similarity1
Active sitei178Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi33 – 57NADPBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processMelanin biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00785

Names & Taxonomyi

Protein namesi
Recommended name:
Trihydroxynaphthalene reductase (EC:1.1.1.-)
Alternative name(s):
T3HN reductase
Gene namesi
Name:THR1
ORF Names:Cob_04570
OrganismiColletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422) (Cucumber anthracnose fungus) (Colletotrichum lagenarium)
Taxonomic identifieri1213857 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeGlomerellalesGlomerellaceaeColletotrichum
Proteomesi
  • UP000014480 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000547831 – 282Trihydroxynaphthalene reductaseAdd BLAST282

Proteomic databases

PRIDEiP87025

Interactioni

Subunit structurei

Homotetramer.

Structurei

3D structure databases

SMRiP87025
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OrthoDBiEOG092C3TSH

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

P87025-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGVTSQSAG SKYDAIPGPL GLASASLMGK VALVTGAGRG IGREMAMELG
60 70 80 90 100
RRGAKVIVNY ANSAETAEEV VQAIKKSGSD AASIKANVSD VDQIVKMFGE
110 120 130 140 150
AKQIWGRLDI VCSNSGVVSF GHVKDVTPEE FDRVFAINTR GQFFVAREAY
160 170 180 190 200
KHLEVGGRLI LMGSITGQAK GVPKHAVYSG SKGTIETFVR CMAIDFGDKK
210 220 230 240 250
ITVNAVAPGG IKTDMYRDVC REYIPNGGEL DDEGVDEFAA GWSPMHRVGL
260 270 280
PIDIARVVCF LASQDGEWIN GKVLGIDGAA CM
Length:282
Mass (Da):29,849
Last modified:September 18, 2013 - v4
Checksum:i69BDAB12F6DA9B23
GO

Sequence cautioni

The sequence BAA18962 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83988 Genomic DNA Translation: BAA18962.1 Sequence problems.
KB725704 Genomic DNA Translation: ENH87277.1

Genome annotation databases

EnsemblFungiiENH87277; ENH87277; Cob_04570

Similar proteinsi

Entry informationi

Entry nameiTHR1_COLOR
AccessioniPrimary (citable) accession number: P87025
Secondary accession number(s): N4VTL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: September 18, 2013
Last modified: May 23, 2018
This is version 80 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health