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Protein

Trihydroxynaphthalene reductase

Gene

THR1

Organism
Colletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422) (Cucumber anthracnose fungus) (Colletotrichum lagenarium)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of 1,3,8-trihydroxynaphthalene (T3HN) into (-)-vermelone. Essential for appressorial penetration of colletotrichum lagenarium.

Pathwayi: melanin biosynthesis

This protein is involved in the pathway melanin biosynthesis, which is part of Pigment biosynthesis.
View all proteins of this organism that are known to be involved in the pathway melanin biosynthesis and in Pigment biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei164SubstrateBy similarity1
Active sitei178Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi33 – 57NADPBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00785.

Names & Taxonomyi

Protein namesi
Recommended name:
Trihydroxynaphthalene reductase (EC:1.1.1.-)
Alternative name(s):
T3HN reductase
Gene namesi
Name:THR1
ORF Names:Cob_04570
OrganismiColletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422) (Cucumber anthracnose fungus) (Colletotrichum lagenarium)
Taxonomic identifieri1213857 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeGlomerellalesGlomerellaceaeColletotrichum
Proteomesi
  • UP000014480 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000547831 – 282Trihydroxynaphthalene reductaseAdd BLAST282

Interactioni

Subunit structurei

Homotetramer.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OrthoDBiEOG092C3TSH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

P87025-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGVTSQSAG SKYDAIPGPL GLASASLMGK VALVTGAGRG IGREMAMELG
60 70 80 90 100
RRGAKVIVNY ANSAETAEEV VQAIKKSGSD AASIKANVSD VDQIVKMFGE
110 120 130 140 150
AKQIWGRLDI VCSNSGVVSF GHVKDVTPEE FDRVFAINTR GQFFVAREAY
160 170 180 190 200
KHLEVGGRLI LMGSITGQAK GVPKHAVYSG SKGTIETFVR CMAIDFGDKK
210 220 230 240 250
ITVNAVAPGG IKTDMYRDVC REYIPNGGEL DDEGVDEFAA GWSPMHRVGL
260 270 280
PIDIARVVCF LASQDGEWIN GKVLGIDGAA CM
Length:282
Mass (Da):29,849
Last modified:September 18, 2013 - v4
Checksum:i69BDAB12F6DA9B23
GO

Sequence cautioni

The sequence BAA18962 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83988 Genomic DNA. Translation: BAA18962.1. Sequence problems.
KB725704 Genomic DNA. Translation: ENH87277.1.

Genome annotation databases

EnsemblFungiiENH87277; ENH87277; Cob_04570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83988 Genomic DNA. Translation: BAA18962.1. Sequence problems.
KB725704 Genomic DNA. Translation: ENH87277.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiENH87277; ENH87277; Cob_04570.

Phylogenomic databases

OrthoDBiEOG092C3TSH.

Enzyme and pathway databases

UniPathwayiUPA00785.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTHR1_COLOR
AccessioniPrimary (citable) accession number: P87025
Secondary accession number(s): N4VTL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: September 18, 2013
Last modified: September 7, 2016
This is version 74 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.