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Protein

Probable L-asparaginase 1

Gene

SPAC186.03

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-asparagine + H2O = L-aspartate + NH3.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49O-isoaspartyl threonine intermediateBy similarity1
Binding sitei96SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-SPO-70614 Amino acid synthesis and interconversion (transamination)

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-asparaginase 1 (EC:3.5.1.1)
Alternative name(s):
L-asparagine amidohydrolase 1
Gene namesi
ORF Names:SPAC186.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC186.03
PomBaseiSPAC186.03

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000000236317 – 360Probable L-asparaginase 1Add BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi351N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP87015
PRIDEiP87015

Interactioni

Protein-protein interaction databases

BioGridi278950, 1 interactor
STRINGi4896.SPAC186.03.1

Structurei

3D structure databases

ProteinModelPortaliP87015
SMRiP87015
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 359Asparaginase/glutaminasePROSITE-ProRule annotationAdd BLAST321

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni129 – 130Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the asparaginase 1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000044165
InParanoidiP87015
KOiK01424
OMAiNVYSTGR
OrthoDBiEOG092C3Z6Q
PhylomeDBiP87015

Family and domain databases

Gene3Di3.40.50.1170, 1 hit
3.40.50.40, 1 hit
InterProiView protein in InterPro
IPR004550 AsnASE_II
IPR036152 Asp/glu_Ase-like_sf
IPR006034 Asparaginase/glutaminase-like
IPR027473 L-asparaginase_C
IPR027474 L-asparaginase_N
IPR037152 L-asparaginase_N_sf
PfamiView protein in Pfam
PF00710 Asparaginase, 1 hit
PIRSFiPIRSF001220 L-ASNase_gatD, 1 hit
PRINTSiPR00139 ASNGLNASE
SMARTiView protein in SMART
SM00870 Asparaginase, 1 hit
SUPFAMiSSF53774 SSF53774, 1 hit
TIGRFAMsiTIGR00520 asnASE_II, 1 hit
PROSITEiView protein in PROSITE
PS51732 ASN_GLN_ASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P87015-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRSIISFLF FSVALCQPFL FQKRSSNISD FISFNASLPN VTIFAMGGTI
60 70 80 90 100
AGYASSSTET VDYAAGSVGI ATLVDAVPAI KNFSNIRGVQ VTNVGSEELT
110 120 130 140 150
PANVLNLTQL ILAEVAKPDV HGIVVTHGTD SLEETAMFLD MTVNTTKPIV
160 170 180 190 200
VVGAMRPSTA ISADGPMNLL NAVVVAASNR SIGRGTMILL NDRIGSAFYT
210 220 230 240 250
TKTNGNMLDT FKSYEAGFLG MILDQRPHFF YSPATPTGKV HFDVSNTTEL
260 270 280 290 300
PAVEILYGYQ GLNPNLAKAA VDLGAKGLVL AGMGAASWTD PGNEVIDGLI
310 320 330 340 350
SNQSIPVVYS HRTMDGFSDY YYNGIPSYFQ NPQKARYMLM LSINAGYSIQ
360
NITDIFSLEY
Length:360
Mass (Da):38,748
Last modified:July 1, 1997 - v1
Checksum:iD5448F487CFB14BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11944 Genomic DNA Translation: CAA72692.1
CU329670 Genomic DNA Translation: CAB75867.1
PIRiT43404
RefSeqiNP_595021.1, NM_001020452.2

Genome annotation databases

EnsemblFungiiSPAC186.03.1; SPAC186.03.1:pep; SPAC186.03
GeneIDi2542491
KEGGispo:SPAC186.03

Similar proteinsi

Entry informationi

Entry nameiASPG1_SCHPO
AccessioniPrimary (citable) accession number: P87015
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health