Probable L-asparaginase 1 precursor - Schizosaccharomyces pombe (Fission yeast)

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Reviewed, UniProtKB/Swiss-Prot P87015 (ASPG1_SCHPO)

Last modified November 3, 2009. Version 54. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Probable L-asparaginase 1
    EC=3.5.1.1
Alternative name(s):
    L-asparagine amidohydrolase 1

Gene names

ORF Names:

SPAC186.03

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-asparagine + H₂O = L-aspartate + NH₃.
Subcellular location	Secreted › cell wall By similarity.
Sequence similarities	Belongs to the asparaginase 1 family.

Ontologies

Keywords
Cellular component	Cell wall Secreted
Domain	Signal
Molecular function	Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	asparagine metabolic process Inferred from electronic annotation. Source: InterPro cellular response to stress Inferred from expression pattern. Source: GeneDB_SPombe
Cellular component	Golgi apparatus Inferred from direct assay. Source: GeneDB_SPombe cell wall Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	asparaginase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

16

Potential

Chain

344

Probable L-asparaginase 1

PRO_0000002363

Sites

Active site

1

By similarity

Active site

1

By similarity

Active site

1

By similarity

Active site

1

By similarity

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

P87015-1 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: D5448F487CFB14BE
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360

38,748

        10         20         30         40         50         60 
MWRSIISFLF FSVALCQPFL FQKRSSNISD FISFNASLPN VTIFAMGGTI AGYASSSTET 

        70         80         90        100        110        120 
VDYAAGSVGI ATLVDAVPAI KNFSNIRGVQ VTNVGSEELT PANVLNLTQL ILAEVAKPDV 

       130        140        150        160        170        180 
HGIVVTHGTD SLEETAMFLD MTVNTTKPIV VVGAMRPSTA ISADGPMNLL NAVVVAASNR 

       190        200        210        220        230        240 
SIGRGTMILL NDRIGSAFYT TKTNGNMLDT FKSYEAGFLG MILDQRPHFF YSPATPTGKV 

       250        260        270        280        290        300 
HFDVSNTTEL PAVEILYGYQ GLNPNLAKAA VDLGAKGLVL AGMGAASWTD PGNEVIDGLI 

       310        320        330        340        350        360 
SNQSIPVVYS HRTMDGFSDY YYNGIPSYFQ NPQKARYMLM LSINAGYSIQ NITDIFSLEY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Bonthron D.T. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 38366 / 972.
[2]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

Cross-references

Sequence databases
	Y11944 Genomic DNA. Translation: CAA72692.1. CU329670 Genomic DNA. Translation: CAB75867.1.
PIR	T43404.
RefSeq	NP_595021.1.
3D structure databases
HSSP	HSSP built from PDB template 1WSA based on UniProtKB P50286.
ModBase	Search...
Protein-protein interaction databases
STRING	P87015.
Genome annotation databases
GeneID	2542491.
KEGG	spo:SPAC186.03.
NMPDR	fig\|4896.1.peg.4991.
Organism-specific databases
GeneDB_Spombe	SPAC186.03.
Phylogenomic databases
OMA	QVANVGS.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-003077-MON.
BRENDA	3.5.1.1. 653.
Gene expression databases
ArrayExpress	P87015.
Family and domain databases
InterPro	IPR004550. AsnASE_II. IPR006034. Asp/Glutamnse. [Graphical view]
PANTHER	PTHR11707. Asp/Glutamnse. 1 hit.
Pfam	PF00710. Asparaginase. 1 hit. [Graphical view]
PRINTS	PR00139. ASNGLNASE.
ProDom	PD003221. Asp/Glutamnse. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00520. asnASE_II. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ASPG1_SCHPO

Accession

Primary (citable) accession number: P87015

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	July 1, 1997
Last modified:	November 3, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents