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P87014

- MAM4_SCHPO

UniProt

P87014 - MAM4_SCHPO

Protein

Protein-S-isoprenylcysteine O-methyltransferase

Gene

mam4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Mediates C-terminal methylation of the isoprenylated C-terminal cysteine in M-factor.

    Catalytic activityi

    S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.

    GO - Molecular functioni

    1. protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity Source: PomBase

    GO - Biological processi

    1. cellular protein localization Source: PomBase
    2. peptide mating pheromone maturation involved in conjugation with cellular fusion Source: PomBase
    3. peptidyl-cysteine methylation Source: PomBase
    4. peptidyl-L-cysteine methyl ester biosynthetic process from peptidyl-cysteine Source: PomBase
    5. response to pheromone involved in conjugation with cellular fusion Source: PomBase

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Pheromone response

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein-S-isoprenylcysteine O-methyltransferase (EC:2.1.1.100)
    Alternative name(s):
    Isoprenylcysteine carboxylmethyltransferase
    Prenylated protein carboxyl methyltransferase
    Short name:
    PPMT
    Prenylcysteine carboxyl methyltransferase
    Short name:
    pcCMT
    Gene namesi
    Name:mam4
    ORF Names:SPAC10F6.12c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC10F6.12c.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: PomBase
    2. endoplasmic reticulum membrane Source: PomBase
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 236236Protein-S-isoprenylcysteine O-methyltransferasePRO_0000209898Add
    BLAST

    Proteomic databases

    MaxQBiP87014.

    Interactioni

    Protein-protein interaction databases

    BioGridi279420. 1 interaction.
    MINTiMINT-4692101.
    STRINGi4896.SPAC10F6.12c-1.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei24 – 4421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei76 – 9621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei174 – 19421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2020.
    HOGENOMiHOG000213961.
    KOiK00587.
    OMAiGSAIVEC.
    OrthoDBiEOG7WHHPD.
    PhylomeDBiP87014.

    Family and domain databases

    InterProiIPR007269. ICMT_MeTrfase.
    IPR025770. PPMT_MeTrfase.
    [Graphical view]
    PfamiPF04140. ICMT. 1 hit.
    [Graphical view]
    PROSITEiPS51564. SAM_ICMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P87014-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNLHTSIAV ASICLTSAFL GCVFGLGFFV WIIYGYSIGG FFAFLSLFHL    50
    LEFYITARFQ GSQLSWDSFI LNNGKAYWLA MLVGLLECLL SGGKSFAKVI 100
    NCLRFPSFLI NFIFSVYQTS ALGFLCLGQY LRSSAMVQAG QSFSHIVASK 150
    RNKDHLLVTD GIYAYVRHPS YVGFFIWALG TQMLLGNFVS TLLFSLVLWK 200
    FFSQRITTEE AYLVSFFGDS YEQYRKKVPS GIPLIP 236
    Length:236
    Mass (Da):26,505
    Last modified:July 1, 1997 - v1
    Checksum:iBE22A8C80BAA16FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87749 Genomic DNA. Translation: BAA18999.1.
    CU329670 Genomic DNA. Translation: CAA15725.1.
    PIRiT43237.
    RefSeqiNP_593263.1. NM_001018660.2.

    Genome annotation databases

    EnsemblFungiiSPAC10F6.12c.1; SPAC10F6.12c.1:pep; SPAC10F6.12c.
    GeneIDi2542982.
    KEGGispo:SPAC10F6.12c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87749 Genomic DNA. Translation: BAA18999.1 .
    CU329670 Genomic DNA. Translation: CAA15725.1 .
    PIRi T43237.
    RefSeqi NP_593263.1. NM_001018660.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279420. 1 interaction.
    MINTi MINT-4692101.
    STRINGi 4896.SPAC10F6.12c-1.

    Proteomic databases

    MaxQBi P87014.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC10F6.12c.1 ; SPAC10F6.12c.1:pep ; SPAC10F6.12c .
    GeneIDi 2542982.
    KEGGi spo:SPAC10F6.12c.

    Organism-specific databases

    PomBasei SPAC10F6.12c.

    Phylogenomic databases

    eggNOGi COG2020.
    HOGENOMi HOG000213961.
    KOi K00587.
    OMAi GSAIVEC.
    OrthoDBi EOG7WHHPD.
    PhylomeDBi P87014.

    Miscellaneous databases

    NextBioi 20804015.
    PROi P87014.

    Family and domain databases

    InterProi IPR007269. ICMT_MeTrfase.
    IPR025770. PPMT_MeTrfase.
    [Graphical view ]
    Pfami PF04140. ICMT. 1 hit.
    [Graphical view ]
    PROSITEi PS51564. SAM_ICMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genes encoding farnesyl cysteine carboxyl methyltransferase in Schizosaccharomyces pombe and Xenopus laevis."
      Imai Y., Davey J., Kawagishi-Kobayashi M., Yamamoto M.
      Mol. Cell. Biol. 17:1543-1551(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiMAM4_SCHPO
    AccessioniPrimary (citable) accession number: P87014
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3