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P87014 (MAM4_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein-S-isoprenylcysteine O-methyltransferase

EC=2.1.1.100
Alternative name(s):
Isoprenylcysteine carboxylmethyltransferase
Prenylated protein carboxyl methyltransferase
Short name=PPMT
Prenylcysteine carboxyl methyltransferase
Short name=pcCMT
Gene names
Name:mam4
ORF Names:SPAC10F6.12c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length236 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Mediates C-terminal methylation of the isoprenylated C-terminal cysteine in M-factor.

Catalytic activity

S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 236236Protein-S-isoprenylcysteine O-methyltransferase
PRO_0000209898

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane24 – 4421Helical; Potential
Transmembrane76 – 9621Helical; Potential
Transmembrane108 – 12821Helical; Potential
Transmembrane174 – 19421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P87014 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: BE22A8C80BAA16FD

FASTA23626,505
        10         20         30         40         50         60 
MGNLHTSIAV ASICLTSAFL GCVFGLGFFV WIIYGYSIGG FFAFLSLFHL LEFYITARFQ 

        70         80         90        100        110        120 
GSQLSWDSFI LNNGKAYWLA MLVGLLECLL SGGKSFAKVI NCLRFPSFLI NFIFSVYQTS 

       130        140        150        160        170        180 
ALGFLCLGQY LRSSAMVQAG QSFSHIVASK RNKDHLLVTD GIYAYVRHPS YVGFFIWALG 

       190        200        210        220        230 
TQMLLGNFVS TLLFSLVLWK FFSQRITTEE AYLVSFFGDS YEQYRKKVPS GIPLIP 

« Hide

References

« Hide 'large scale' references
[1]"Genes encoding farnesyl cysteine carboxyl methyltransferase in Schizosaccharomyces pombe and Xenopus laevis."
Imai Y., Davey J., Kawagishi-Kobayashi M., Yamamoto M.
Mol. Cell. Biol. 17:1543-1551(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D87749 Genomic DNA. Translation: BAA18999.1.
CU329670 Genomic DNA. Translation: CAA15725.1.
PIRT43237.
RefSeqNP_593263.1. NM_001018660.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid279420. 1 interaction.
MINTMINT-4692101.
STRING4896.SPAC10F6.12c-1.

Proteomic databases

MaxQBP87014.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC10F6.12c.1; SPAC10F6.12c.1:pep; SPAC10F6.12c.
GeneID2542982.
KEGGspo:SPAC10F6.12c.

Organism-specific databases

PomBaseSPAC10F6.12c.

Phylogenomic databases

eggNOGCOG2020.
HOGENOMHOG000213961.
KOK00587.
OMAGSAIVEC.
OrthoDBEOG7WHHPD.
PhylomeDBP87014.

Family and domain databases

InterProIPR007269. ICMT_MeTrfase.
IPR025770. PPMT_MeTrfase.
[Graphical view]
PfamPF04140. ICMT. 1 hit.
[Graphical view]
PROSITEPS51564. SAM_ICMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20804015.
PROP87014.

Entry information

Entry nameMAM4_SCHPO
AccessionPrimary (citable) accession number: P87014
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: July 1, 1997
Last modified: May 14, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names