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P87014

- MAM4_SCHPO

UniProt

P87014 - MAM4_SCHPO

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Protein

Protein-S-isoprenylcysteine O-methyltransferase

Gene

mam4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Mediates C-terminal methylation of the isoprenylated C-terminal cysteine in M-factor.

Catalytic activityi

S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.

GO - Molecular functioni

  1. protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity Source: PomBase

GO - Biological processi

  1. cellular protein localization Source: PomBase
  2. peptide mating pheromone maturation involved in conjugation with cellular fusion Source: PomBase
  3. peptidyl-cysteine methylation Source: PomBase
  4. peptidyl-L-cysteine methyl ester biosynthetic process from peptidyl-cysteine Source: PomBase
  5. response to pheromone involved in conjugation with cellular fusion Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Pheromone response

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-S-isoprenylcysteine O-methyltransferase (EC:2.1.1.100)
Alternative name(s):
Isoprenylcysteine carboxylmethyltransferase
Prenylated protein carboxyl methyltransferase
Short name:
PPMT
Prenylcysteine carboxyl methyltransferase
Short name:
pcCMT
Gene namesi
Name:mam4
ORF Names:SPAC10F6.12c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC10F6.12c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence AnalysisAdd
BLAST
Transmembranei24 – 4421HelicalSequence AnalysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence AnalysisAdd
BLAST
Transmembranei108 – 12821HelicalSequence AnalysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: PomBase
  2. endoplasmic reticulum membrane Source: PomBase
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Protein-S-isoprenylcysteine O-methyltransferasePRO_0000209898Add
BLAST

Proteomic databases

MaxQBiP87014.

Interactioni

Protein-protein interaction databases

BioGridi279420. 1 interaction.
MINTiMINT-4692101.
STRINGi4896.SPAC10F6.12c-1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2020.
HOGENOMiHOG000213961.
InParanoidiP87014.
KOiK00587.
OMAiGSAIVEC.
OrthoDBiEOG7WHHPD.
PhylomeDBiP87014.

Family and domain databases

InterProiIPR007269. ICMT_MeTrfase.
IPR025770. PPMT_MeTrfase.
[Graphical view]
PfamiPF04140. ICMT. 1 hit.
[Graphical view]
PROSITEiPS51564. SAM_ICMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P87014-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNLHTSIAV ASICLTSAFL GCVFGLGFFV WIIYGYSIGG FFAFLSLFHL
60 70 80 90 100
LEFYITARFQ GSQLSWDSFI LNNGKAYWLA MLVGLLECLL SGGKSFAKVI
110 120 130 140 150
NCLRFPSFLI NFIFSVYQTS ALGFLCLGQY LRSSAMVQAG QSFSHIVASK
160 170 180 190 200
RNKDHLLVTD GIYAYVRHPS YVGFFIWALG TQMLLGNFVS TLLFSLVLWK
210 220 230
FFSQRITTEE AYLVSFFGDS YEQYRKKVPS GIPLIP
Length:236
Mass (Da):26,505
Last modified:July 1, 1997 - v1
Checksum:iBE22A8C80BAA16FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87749 Genomic DNA. Translation: BAA18999.1.
CU329670 Genomic DNA. Translation: CAA15725.1.
PIRiT43237.
RefSeqiNP_593263.1. NM_001018660.2.

Genome annotation databases

EnsemblFungiiSPAC10F6.12c.1; SPAC10F6.12c.1:pep; SPAC10F6.12c.
GeneIDi2542982.
KEGGispo:SPAC10F6.12c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87749 Genomic DNA. Translation: BAA18999.1 .
CU329670 Genomic DNA. Translation: CAA15725.1 .
PIRi T43237.
RefSeqi NP_593263.1. NM_001018660.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279420. 1 interaction.
MINTi MINT-4692101.
STRINGi 4896.SPAC10F6.12c-1.

Proteomic databases

MaxQBi P87014.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC10F6.12c.1 ; SPAC10F6.12c.1:pep ; SPAC10F6.12c .
GeneIDi 2542982.
KEGGi spo:SPAC10F6.12c.

Organism-specific databases

PomBasei SPAC10F6.12c.

Phylogenomic databases

eggNOGi COG2020.
HOGENOMi HOG000213961.
InParanoidi P87014.
KOi K00587.
OMAi GSAIVEC.
OrthoDBi EOG7WHHPD.
PhylomeDBi P87014.

Miscellaneous databases

NextBioi 20804015.
PROi P87014.

Family and domain databases

InterProi IPR007269. ICMT_MeTrfase.
IPR025770. PPMT_MeTrfase.
[Graphical view ]
Pfami PF04140. ICMT. 1 hit.
[Graphical view ]
PROSITEi PS51564. SAM_ICMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genes encoding farnesyl cysteine carboxyl methyltransferase in Schizosaccharomyces pombe and Xenopus laevis."
    Imai Y., Davey J., Kawagishi-Kobayashi M., Yamamoto M.
    Mol. Cell. Biol. 17:1543-1551(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiMAM4_SCHPO
AccessioniPrimary (citable) accession number: P87014
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: July 1, 1997
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3