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Thunnus albacares (Yellowfin tuna) (Neothunnus macropterus)
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli


Catalytic activityi

2-phospho-D-glycerate = phosphoenolpyruvate + H2O.By similarity


Mg2+By similarityNote: Mg2+ is required for catalysis and for stabilizing the dimer.By similarity

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.By similarity
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Alpha-enolase (ENO1), Beta-enolase (ENO3)
  5. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi


Molecular functionLyase
Biological processGlycolysis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00187.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-enolase1 Publication (EC: similarity)
Alternative name(s):
2-phospho-D-glycerate hydro-lyaseBy similarity
Enolase 3By similarity
Muscle-specific enolaseBy similarity
Short name:
MSEBy similarity
Skeletal muscle enolaseBy similarity
Gene namesi
Name:ENO3By similarity
OrganismiThunnus albacares (Yellowfin tuna) (Neothunnus macropterus)
Taxonomic identifieri8236 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPelagiariaScombriformesScombridaeThunnus

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti


Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.1 Publication

Keywords - Diseasei


Protein family/group databases

Allergomei10132. Thu a 2.
10153. Thu a 2.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004250771 – ›12Beta-enolaseAdd BLAST›12


Subunit structurei

Dimer.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the enolase family.Sequence analysis


Sequence statusi: Fragment.

Mass (Da):1,387
Last modified:January 22, 2014 - v1

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei121 Publication1

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiENOB_THUAL
AccessioniPrimary (citable) accession number: P86978
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 22, 2014
Last sequence update: January 22, 2014
Last modified: January 7, 2015
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program


Keywords - Technical termi

Direct protein sequencing


  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families