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P86956

- HEX_PINMA

UniProt

P86956 - HEX_PINMA

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Protein

Putative beta-hexosaminidase

Gene
N/A
Organism
Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.By similarity

Pathwayi

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC
  2. polysaccharide binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. chitin catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00349.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative beta-hexosaminidase (EC:3.2.1.52By similarity)
Alternative name(s):
Beta-N-acetylhexosaminidaseBy similarity
ChitobiaseBy similarity
N-acetyl-beta-glucosaminidaseBy similarity
OrganismiPinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster)
Taxonomic identifieri104660 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaPterioidaPterioideaPteriidaePinctada

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 11301107Putative beta-hexosaminidaseSequence AnalysisPRO_0000413087Add
BLAST

Expressioni

Tissue specificityi

Prismatic layer of shell (at protein level). Expressed primarily in the mantle with highest level in the mantle edge and lower level in the mantle pallium.1 Publication

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi936 – 100166Pro-richSequence AnalysisAdd
BLAST
Compositional biasi1003 – 1128126Gln-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 20 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.40.290. 1 hit.
3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProiIPR025705. Beta_hexosaminidase_sua/sub.
IPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR004866. CHB/HEX_N_dom.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF03173. CHB_HEX. 1 hit.
PF00728. Glyco_hydro_20. 1 hit.
[Graphical view]
PRINTSiPR00738. GLHYDRLASE20.
SUPFAMiSSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 2 hits.
SSF55545. SSF55545. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P86956-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKWVKSGVGI LGILLIICHA VTSQRRILDI TDNLKITFKT ISNFGPRAQS
60 70 80 90 100
IQNVTIENVG IKDIPDFGWR CYFCHDQLLF PGTFNLARSQ YFLRPILDNY
110 120 130 140 150
VVLSDGFLLE FIKGCMYRIT PIPRNAPIKT RDKREFTLLA EQFSVSKYDS
160 170 180 190 200
FPNWYCETIS GGNTEVANIR STENLKYVED FDSSYNWFRI PHDFRSVPLQ
210 220 230 240 250
PQDRYSANHK ASSVEECKYK VIPTPVKASV RKVQRNFGTT VYYGTTDTSI
260 270 280 290 300
RGKLFKVAEK LALKHKLGLV EMTPGQPVNN GISLVVTGNY IERNIPSPDE
310 320 330 340 350
AYRLSVSADL ISIEAPALPG LINGIETMHS LSAWDMALPY GGVKDFPRFP
360 370 380 390 400
FRGIFLDIAS NFPGYNYMMK FLTVMAQYKL NKLVLPLYNN EGFRLELNDS
410 420 430 440 450
PGYEFQALHL VGGNRCHDLK EENCLFSQLG SFAGNSDGYL TKGDMVDLIK
460 470 480 490 500
TADLLNIEII MSLNIGESAR GAIVPLKTSK HNRLLYDPED TDFVDRFYPQ
510 520 530 540 550
KDSSMNPCRE ETMIFYDHML KQLKAIYKAA SVPLKTIMIG SKVNFDQVLN
560 570 580 590 600
SKYCYPKNLN STQRLMEREN LERNINGFKL NFTKRLVKTA HDNGINEVMA
610 620 630 640 650
IDDVFTTEFD AAGNTPNTVY DTVDSETNKT RFNATVTAVH SRYDTVRDER
660 670 680 690 700
LWKRGDRFAE LGYKVIISPP ILDFNYAVEP DPDRPGDYDS VIRNISFSKL
710 720 730 740 750
FRFVPDSHCC NIPNAIQHDC ALESDCTTAG PPDSYIGTLG KLDTRKLRSL
760 770 780 790 800
KDWNELLFPR LLIFAERSWH KSSWEDSFEP HRVRMNNITR QIITNYTVPN
810 820 830 840 850
WNDIIQEESK VLGCISRKEK LRLMHEDGLK PYVEPPGARL LGGNTMRIAA
860 870 880 890 900
STTEDSFWVQ ASVNGNPWTD NVKVLDVNPT DSVRLRTVHP AKAELRSKEV
910 920 930 940 950
KLNLTSLPTP REQFRKIAQD ALSRRIGIDI QRARMPPMPV NPTYRPPVPL
960 970 980 990 1000
PSFDPADDRA PDLAAIAAAH PPPLPPGMPP HMMPNMPFPP RPPFVPPLLP
1010 1020 1030 1040 1050
PGQMRALGQQ AGQALRGQGQ QTGQQTLPAQ PRGPMGLTGQ AAGTGVAGQS
1060 1070 1080 1090 1100
GQQPSAAGQG TQQGLPGQQR TGVVPGQWPF FPGMPAAQFP PMFNPQMQRA
1110 1120 1130
LQMRGQGQIP QTQGAVAGAG QSRVPQQQAG
Length:1,130
Mass (Da):126,718
Last modified:October 19, 2011 - v1
Checksum:i9F180107C5016EA5
GO

Sequence cautioni

The sequence GT279548 differs from that shown. Reason: Frameshift at position 694. Curated
The sequence GT280934 differs from that shown. Reason: Frameshift at position 615. Curated
The sequence GT282050 differs from that shown. Reason: Frameshift at position 756. Curated
The sequence GT282702 differs from that shown. Reason: Frameshift at position 812. Curated
The sequence GT282776 differs from that shown. Reason: Frameshift at positions 675, 684, 687 and 690. Curated
The sequence GT283781 differs from that shown. Reason: Frameshift at position 1069. Curated
The sequence GT284443 differs from that shown. Reason: Premature stop codon at position 218.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti391 – 3911E → Q in GT281097. (PubMed:19915030)Curated
Sequence conflicti487 – 4871D → S in GT279548. (PubMed:19915030)Curated
Sequence conflicti538 – 5381M → L in GT282050. (PubMed:19915030)Curated
Sequence conflicti614 – 6141N → H in GT280934. (PubMed:19915030)Curated
Sequence conflicti623 – 6231V → M in GT281082. (PubMed:19915030)Curated
Sequence conflicti623 – 6231V → M in GT282050. (PubMed:19915030)Curated
Sequence conflicti623 – 6231V → M in GT281480. (PubMed:19915030)Curated
Sequence conflicti623 – 6231V → M in GT279953. (PubMed:19915030)Curated
Sequence conflicti653 – 6531K → E in GT284045. (PubMed:19915030)Curated
Sequence conflicti658 – 6581F → V in GT279353. (PubMed:19915030)Curated
Sequence conflicti687 – 6871D → E in GT279548. (PubMed:19915030)Curated
Sequence conflicti691 – 6911V → R in GT279548. (PubMed:19915030)Curated
Sequence conflicti743 – 7431D → N in GT278127. (PubMed:19915030)Curated
Sequence conflicti752 – 7521D → E in GT282050. (PubMed:19915030)Curated
Sequence conflicti806 – 8061Q → P in GT282702. (PubMed:19915030)Curated
Sequence conflicti806 – 8061Q → P in GT281480. (PubMed:19915030)Curated
Sequence conflicti807 – 8071E → G in GT282702. (PubMed:19915030)Curated
Sequence conflicti863 – 8653VNG → PSW in GT284045. (PubMed:19915030)Curated
Sequence conflicti866 – 87611NPWTDNVKVLD → SP in GT283781. (PubMed:19915030)CuratedAdd
BLAST
Sequence conflicti870 – 8712DN → GH in GT284045. (PubMed:19915030)Curated
Sequence conflicti957 – 9571D → N in GT279087. (PubMed:19915030)Curated
Sequence conflicti964 – 9641A → T in GT279087. (PubMed:19915030)Curated
Sequence conflicti1104 – 11041R → K in GT283348. (PubMed:19915030)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GT277795 mRNA. No translation available.
GT278040 mRNA. No translation available.
GT278051 mRNA. No translation available.
GT278127 mRNA. No translation available.
GT278167 mRNA. No translation available.
GT278276 mRNA. No translation available.
GT278283 mRNA. No translation available.
GT278457 mRNA. No translation available.
GT278599 mRNA. No translation available.
GT279087 mRNA. No translation available.
GT279290 mRNA. No translation available.
GT279353 mRNA. No translation available.
GT279393 mRNA. No translation available.
GT279548 mRNA. No translation available.
GT279589 mRNA. No translation available.
GT279825 mRNA. No translation available.
GT279940 mRNA. No translation available.
GT279953 mRNA. No translation available.
GT280934 mRNA. No translation available.
GT280997 mRNA. No translation available.
GT281082 mRNA. No translation available.
GT281097 mRNA. No translation available.
GT281480 mRNA. No translation available.
GT281527 mRNA. No translation available.
GT281701 mRNA. No translation available.
GT281791 mRNA. No translation available.
GT281846 mRNA. No translation available.
GT282021 mRNA. No translation available.
GT282046 mRNA. No translation available.
GT282050 mRNA. No translation available.
GT282275 mRNA. No translation available.
GT282639 mRNA. No translation available.
GT282702 mRNA. No translation available.
GT282719 mRNA. No translation available.
GT282776 mRNA. No translation available.
GT283348 mRNA. No translation available.
GT283584 mRNA. No translation available.
GT283781 mRNA. No translation available.
GT284045 mRNA. No translation available.
GT284443 mRNA. No translation available.
EZ420123 mRNA. No translation available.
EZ420192 mRNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GT277795 mRNA. No translation available.
GT278040 mRNA. No translation available.
GT278051 mRNA. No translation available.
GT278127 mRNA. No translation available.
GT278167 mRNA. No translation available.
GT278276 mRNA. No translation available.
GT278283 mRNA. No translation available.
GT278457 mRNA. No translation available.
GT278599 mRNA. No translation available.
GT279087 mRNA. No translation available.
GT279290 mRNA. No translation available.
GT279353 mRNA. No translation available.
GT279393 mRNA. No translation available.
GT279548 mRNA. No translation available.
GT279589 mRNA. No translation available.
GT279825 mRNA. No translation available.
GT279940 mRNA. No translation available.
GT279953 mRNA. No translation available.
GT280934 mRNA. No translation available.
GT280997 mRNA. No translation available.
GT281082 mRNA. No translation available.
GT281097 mRNA. No translation available.
GT281480 mRNA. No translation available.
GT281527 mRNA. No translation available.
GT281701 mRNA. No translation available.
GT281791 mRNA. No translation available.
GT281846 mRNA. No translation available.
GT282021 mRNA. No translation available.
GT282046 mRNA. No translation available.
GT282050 mRNA. No translation available.
GT282275 mRNA. No translation available.
GT282639 mRNA. No translation available.
GT282702 mRNA. No translation available.
GT282719 mRNA. No translation available.
GT282776 mRNA. No translation available.
GT283348 mRNA. No translation available.
GT283584 mRNA. No translation available.
GT283781 mRNA. No translation available.
GT284045 mRNA. No translation available.
GT284443 mRNA. No translation available.
EZ420123 mRNA. No translation available.
EZ420192 mRNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00349 .

Family and domain databases

Gene3Di 2.60.40.290. 1 hit.
3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProi IPR025705. Beta_hexosaminidase_sua/sub.
IPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR004866. CHB/HEX_N_dom.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF03173. CHB_HEX. 1 hit.
PF00728. Glyco_hydro_20. 1 hit.
[Graphical view ]
PRINTSi PR00738. GLHYDRLASE20.
SUPFAMi SSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 2 hits.
SSF55545. SSF55545. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION.
    Tissue: Mantle1 Publication.
  2. "Different secretory repertoires control the biomineralization processes of prism and nacre deposition of the pearl oyster shell."
    Marie B., Joubert C., Tayale A., Zanella-Cleon I., Belliard C., Piquemal D., Cochennec-Laureau N., Marin F., Gueguen Y., Montagnani C.
    Proc. Natl. Acad. Sci. U.S.A. 109:20986-20991(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 658-664; 761-767 AND 1005-1016, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Shell.

Entry informationi

Entry nameiHEX_PINMA
AccessioniPrimary (citable) accession number: P86956
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 19, 2011
Last modified: October 29, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3