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P86956

- HEX_PINMA

UniProt

P86956 - HEX_PINMA

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Protein

Putative beta-hexosaminidase

Gene
N/A
Organism
Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.By similarity

Pathwayi

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC
  2. polysaccharide binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. chitin catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00349.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative beta-hexosaminidase (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase
Chitobiase
N-acetyl-beta-glucosaminidase
OrganismiPinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster)
Taxonomic identifieri104660 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaPterioidaPterioideaPteriidaePinctada

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 11301107Putative beta-hexosaminidasePRO_0000413087Add
BLAST

Expressioni

Tissue specificityi

Prismatic layer of shell (at protein level). Expressed primarily in the mantle with highest level in the mantle edge and lower level in the mantle pallium.1 Publication

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi936 – 100166Pro-richAdd
BLAST
Compositional biasi1003 – 1128126Gln-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.40.290. 1 hit.
3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProiIPR025705. Beta_hexosaminidase_sua/sub.
IPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR004866. CHB/HEX_N_dom.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF03173. CHB_HEX. 1 hit.
PF00728. Glyco_hydro_20. 1 hit.
[Graphical view]
PRINTSiPR00738. GLHYDRLASE20.
SUPFAMiSSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 2 hits.
SSF55545. SSF55545. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P86956-1 [UniParc]FASTAAdd to Basket

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MKWVKSGVGI LGILLIICHA VTSQRRILDI TDNLKITFKT ISNFGPRAQS     50
IQNVTIENVG IKDIPDFGWR CYFCHDQLLF PGTFNLARSQ YFLRPILDNY 100
VVLSDGFLLE FIKGCMYRIT PIPRNAPIKT RDKREFTLLA EQFSVSKYDS 150
FPNWYCETIS GGNTEVANIR STENLKYVED FDSSYNWFRI PHDFRSVPLQ 200
PQDRYSANHK ASSVEECKYK VIPTPVKASV RKVQRNFGTT VYYGTTDTSI 250
RGKLFKVAEK LALKHKLGLV EMTPGQPVNN GISLVVTGNY IERNIPSPDE 300
AYRLSVSADL ISIEAPALPG LINGIETMHS LSAWDMALPY GGVKDFPRFP 350
FRGIFLDIAS NFPGYNYMMK FLTVMAQYKL NKLVLPLYNN EGFRLELNDS 400
PGYEFQALHL VGGNRCHDLK EENCLFSQLG SFAGNSDGYL TKGDMVDLIK 450
TADLLNIEII MSLNIGESAR GAIVPLKTSK HNRLLYDPED TDFVDRFYPQ 500
KDSSMNPCRE ETMIFYDHML KQLKAIYKAA SVPLKTIMIG SKVNFDQVLN 550
SKYCYPKNLN STQRLMEREN LERNINGFKL NFTKRLVKTA HDNGINEVMA 600
IDDVFTTEFD AAGNTPNTVY DTVDSETNKT RFNATVTAVH SRYDTVRDER 650
LWKRGDRFAE LGYKVIISPP ILDFNYAVEP DPDRPGDYDS VIRNISFSKL 700
FRFVPDSHCC NIPNAIQHDC ALESDCTTAG PPDSYIGTLG KLDTRKLRSL 750
KDWNELLFPR LLIFAERSWH KSSWEDSFEP HRVRMNNITR QIITNYTVPN 800
WNDIIQEESK VLGCISRKEK LRLMHEDGLK PYVEPPGARL LGGNTMRIAA 850
STTEDSFWVQ ASVNGNPWTD NVKVLDVNPT DSVRLRTVHP AKAELRSKEV 900
KLNLTSLPTP REQFRKIAQD ALSRRIGIDI QRARMPPMPV NPTYRPPVPL 950
PSFDPADDRA PDLAAIAAAH PPPLPPGMPP HMMPNMPFPP RPPFVPPLLP 1000
PGQMRALGQQ AGQALRGQGQ QTGQQTLPAQ PRGPMGLTGQ AAGTGVAGQS 1050
GQQPSAAGQG TQQGLPGQQR TGVVPGQWPF FPGMPAAQFP PMFNPQMQRA 1100
LQMRGQGQIP QTQGAVAGAG QSRVPQQQAG 1130
Length:1,130
Mass (Da):126,718
Last modified:October 19, 2011 - v1
Checksum:i9F180107C5016EA5
GO

Sequence cautioni

The sequence GT284443 differs from that shown. Reason: Premature stop codon at position 218.
The sequence GT279548 differs from that shown. Reason: Frameshift at position 694.
The sequence GT280934 differs from that shown. Reason: Frameshift at position 615.
The sequence GT282050 differs from that shown. Reason: Frameshift at position 756.
The sequence GT282702 differs from that shown. Reason: Frameshift at position 812.
The sequence GT282776 differs from that shown. Reason: Frameshift at positions 675, 684, 687 and 690.
The sequence GT283781 differs from that shown. Reason: Frameshift at position 1069.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti391 – 3911E → Q in GT281097. 1 Publication
Sequence conflicti487 – 4871D → S in GT279548. 1 Publication
Sequence conflicti538 – 5381M → L in GT282050. 1 Publication
Sequence conflicti614 – 6141N → H in GT280934. 1 Publication
Sequence conflicti623 – 6231V → M in GT281082. 1 Publication
Sequence conflicti623 – 6231V → M in GT282050. 1 Publication
Sequence conflicti623 – 6231V → M in GT281480. 1 Publication
Sequence conflicti623 – 6231V → M in GT279953. 1 Publication
Sequence conflicti653 – 6531K → E in GT284045. 1 Publication
Sequence conflicti658 – 6581F → V in GT279353. 1 Publication
Sequence conflicti687 – 6871D → E in GT279548. 1 Publication
Sequence conflicti691 – 6911V → R in GT279548. 1 Publication
Sequence conflicti743 – 7431D → N in GT278127. 1 Publication
Sequence conflicti752 – 7521D → E in GT282050. 1 Publication
Sequence conflicti806 – 8061Q → P in GT282702. 1 Publication
Sequence conflicti806 – 8061Q → P in GT281480. 1 Publication
Sequence conflicti807 – 8071E → G in GT282702. 1 Publication
Sequence conflicti863 – 8653VNG → PSW in GT284045. 1 Publication
Sequence conflicti866 – 87611NPWTDNVKVLD → SP in GT283781. 1 PublicationAdd
BLAST
Sequence conflicti870 – 8712DN → GH in GT284045. 1 Publication
Sequence conflicti957 – 9571D → N in GT279087. 1 Publication
Sequence conflicti964 – 9641A → T in GT279087. 1 Publication
Sequence conflicti1104 – 11041R → K in GT283348. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GT277795 mRNA. No translation available.
GT278040 mRNA. No translation available.
GT278051 mRNA. No translation available.
GT278127 mRNA. No translation available.
GT278167 mRNA. No translation available.
GT278276 mRNA. No translation available.
GT278283 mRNA. No translation available.
GT278457 mRNA. No translation available.
GT278599 mRNA. No translation available.
GT279087 mRNA. No translation available.
GT279290 mRNA. No translation available.
GT279353 mRNA. No translation available.
GT279393 mRNA. No translation available.
GT279548 mRNA. No translation available.
GT279589 mRNA. No translation available.
GT279825 mRNA. No translation available.
GT279940 mRNA. No translation available.
GT279953 mRNA. No translation available.
GT280934 mRNA. No translation available.
GT280997 mRNA. No translation available.
GT281082 mRNA. No translation available.
GT281097 mRNA. No translation available.
GT281480 mRNA. No translation available.
GT281527 mRNA. No translation available.
GT281701 mRNA. No translation available.
GT281791 mRNA. No translation available.
GT281846 mRNA. No translation available.
GT282021 mRNA. No translation available.
GT282046 mRNA. No translation available.
GT282050 mRNA. No translation available.
GT282275 mRNA. No translation available.
GT282639 mRNA. No translation available.
GT282702 mRNA. No translation available.
GT282719 mRNA. No translation available.
GT282776 mRNA. No translation available.
GT283348 mRNA. No translation available.
GT283584 mRNA. No translation available.
GT283781 mRNA. No translation available.
GT284045 mRNA. No translation available.
GT284443 mRNA. No translation available.
EZ420123 mRNA. No translation available.
EZ420192 mRNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GT277795 mRNA. No translation available.
GT278040 mRNA. No translation available.
GT278051 mRNA. No translation available.
GT278127 mRNA. No translation available.
GT278167 mRNA. No translation available.
GT278276 mRNA. No translation available.
GT278283 mRNA. No translation available.
GT278457 mRNA. No translation available.
GT278599 mRNA. No translation available.
GT279087 mRNA. No translation available.
GT279290 mRNA. No translation available.
GT279353 mRNA. No translation available.
GT279393 mRNA. No translation available.
GT279548 mRNA. No translation available.
GT279589 mRNA. No translation available.
GT279825 mRNA. No translation available.
GT279940 mRNA. No translation available.
GT279953 mRNA. No translation available.
GT280934 mRNA. No translation available.
GT280997 mRNA. No translation available.
GT281082 mRNA. No translation available.
GT281097 mRNA. No translation available.
GT281480 mRNA. No translation available.
GT281527 mRNA. No translation available.
GT281701 mRNA. No translation available.
GT281791 mRNA. No translation available.
GT281846 mRNA. No translation available.
GT282021 mRNA. No translation available.
GT282046 mRNA. No translation available.
GT282050 mRNA. No translation available.
GT282275 mRNA. No translation available.
GT282639 mRNA. No translation available.
GT282702 mRNA. No translation available.
GT282719 mRNA. No translation available.
GT282776 mRNA. No translation available.
GT283348 mRNA. No translation available.
GT283584 mRNA. No translation available.
GT283781 mRNA. No translation available.
GT284045 mRNA. No translation available.
GT284443 mRNA. No translation available.
EZ420123 mRNA. No translation available.
EZ420192 mRNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00349 .

Family and domain databases

Gene3Di 2.60.40.290. 1 hit.
3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProi IPR025705. Beta_hexosaminidase_sua/sub.
IPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR004866. CHB/HEX_N_dom.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF03173. CHB_HEX. 1 hit.
PF00728. Glyco_hydro_20. 1 hit.
[Graphical view ]
PRINTSi PR00738. GLHYDRLASE20.
SUPFAMi SSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 2 hits.
SSF55545. SSF55545. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION.
    Tissue: Mantle.
  2. "Different secretory repertoires control the biomineralization processes of prism and nacre deposition of the pearl oyster shell."
    Marie B., Joubert C., Tayale A., Zanella-Cleon I., Belliard C., Piquemal D., Cochennec-Laureau N., Marin F., Gueguen Y., Montagnani C.
    Proc. Natl. Acad. Sci. U.S.A. 109:20986-20991(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 658-664; 761-767 AND 1005-1016, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Shell.

Entry informationi

Entry nameiHEX_PINMA
AccessioniPrimary (citable) accession number: P86956
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 19, 2011
Last modified: June 11, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi