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Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Zinc 1; catalyticBy similarity1
Metal bindingi67Zinc 1; catalyticBy similarity1
Metal bindingi97Zinc 2By similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi111Zinc 2By similarity1
Metal bindingi174Zinc 1; catalyticBy similarity1
Binding sitei223NADBy similarity1
Binding sitei228NADBy similarity1
Binding sitei369NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi199 – 204NADBy similarity6
Nucleotide bindingi292 – 294NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1By similarity (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase A subunitBy similarity
Gene namesi
Name:ADH1By similarity
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetus
Proteomesi
  • UP000189706 Componenti: Genome assembly

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004053101 – 374Alcohol dehydrogenase 1Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylserineBy similarity1
Modified residuei233N6-succinyllysineBy similarity1
Modified residuei339N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP86885.
SMRiP86885.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P86885-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
STAGKVIKCK AAVLWETNKP FSIEEIEVAP PKAHEVRIKM VATGICRTDD
60 70 80 90 100
HAATGNFVTP LPIVLGHEGA GIVESVGEGV TSVKPGDKVI PLFSPQCGKC
110 120 130 140 150
RVCKHPESNL CIKNDLAAPR GTLLDGTCRF TCKGKSIHNF LSTSTYSQYT
160 170 180 190 200
VVDEMAVAKI DEASPLEKVC LIGCGFTTGY GSAVQFAKVT PGSSCAVFGL
210 220 230 240 250
GGVGLSVIIG CKTAGAARII GVDTNKDKFA KAKELGATEC INPLDYNKPI
260 270 280 290 300
AEVLQEMTDG GVDFSFEVVG QLDTMMSALD SCHAACGVSV IIGVPPNAQN
310 320 330 340 350
LSVNPMLLLG GRTWKGAIFG GYKSKDAVPK LVADFMAKKF PLEPLITHVL
360 370
PFEKINEGFD LLRSGKSIRT VLTF
Length:374
Mass (Da):39,541
Last modified:March 8, 2011 - v1
Checksum:i994698F484792BE5
GO

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiADH1_MESAU
AccessioniPrimary (citable) accession number: P86885
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: July 5, 2017
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families