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Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Columba livia (Rock dove)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Zinc 1; catalyticBy similarity1
Metal bindingi68Zinc 1; catalyticBy similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi175Zinc 1; catalyticBy similarity1
Binding sitei224NADBy similarity1
Binding sitei229NADBy similarity1
Binding sitei370NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi200 – 205NADBy similarity6
Nucleotide bindingi293 – 295NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BRENDAi1.1.1.1. 1579.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1By similarity (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase IBy similarity
Gene namesi
Name:ADH1By similarity
OrganismiColumba livia (Rock dove)
Taxonomic identifieri8932 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeColumbiformesColumbidaeColumba

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004053111 – 375Alcohol dehydrogenase 1Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP86883.
SMRiP86883.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P86883-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ATSGKVIRCR AAVAWAVGKP LSVEEVEVAP PKAGEVRIKI VATGICRTDD
60 70 80 90 100
HVVKGCIANV EFPVIPGHEG AGIVESIGEG VTSVKPGDKV IPLCIPNCGE
110 120 130 140 150
CTFCLNPEAS YCVKSHFSEP QNLMPDKTSR FTCKGKQIHH FMWVSTFAEY
160 170 180 190 200
TVAPETAVAK IDSAAPLDKV CLLGCGFSTG YGAAINTAKV KPGSTCAVFG
210 220 230 240 250
LGGVGLSVVM GCKVAGASRI IAIDINKDKF AKAKELGATD CINPQDFNKP
260 270 280 290 300
IQEVVTEMTG HEVDYSFEVI GRADTMIAAL ASCNMNTGVF VMVGVAPSDA
310 320 330 340 350
VISVDPLLLL TGRTHKGTLV GGSKGRNFIP RLVSSYLEKK FNSDLLITHT
360 370
LPFAKVNEGF ALLHAGKSIR TVLLF
Length:375
Mass (Da):39,598
Last modified:March 8, 2011 - v1
Checksum:iF5BB4622D3FFF860
GO

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiADH1_COLLI
AccessioniPrimary (citable) accession number: P86883
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: May 10, 2017
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families