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P86875

- HUGA_VESMG

UniProt

P86875 - HUGA_VESMG

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Protein

Hyaluronidase

Gene
N/A
Organism
Vespa magnifica (Hornet)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides By similarity.

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei135 – 1351Proton donor By similarityBy similarity

GO - Molecular functioni

  1. hyalurononglucosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. defense response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase (EC:3.2.1.35)
Short name:
Hya
Alternative name(s):
Hyaluronoglucosaminidase
Allergen: Vesp ma 2
OrganismiVespa magnifica (Hornet)
Taxonomic identifieri202807 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespa

Subcellular locationi

Secreted By similarity1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.2 Publications

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei9454. Vesp ma 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26261 PublicationAdd
BLAST
Chaini27 – 357331HyaluronidasePRO_0000405128Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 334 By similarityBy similarity
Glycosylationi105 – 1051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi125 – 1251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi153 – 1531N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi211 ↔ 223 By similarityBy similarity
Glycosylationi351 – 3511N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR001329. Venom_Hyaluronidase.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PRINTSiPR00846. GLHYDRLASE56.
PR00847. HYALURONDASE.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P86875-1 [UniParc]FASTAAdd to Basket

« Hide

MLLVTLFLFF LQALVNGDSC GSNCEKSERP KRVFNIYWNV PTFMCHQYGL    50
YFDEVTNFNI KHNSKDNFQG DKIAIFYDPG EFPALLPLNY GKYKIRNGGV 100
PQEGNITIHL QRFIEYLDKT YPNRNFSGIG VIDFERWRPI FRQNWGNMKI 150
YKNFSIDLVR KEHPFWNKKM IELEASKRFE KYARLFMEET LKLAKKTRKQ 200
ADWGYYGYPY CFNMSPTNFV PDCDVTARDE NNEMSWLFNN QNVLLPSVYI 250
RRELTPDQRI GLVQGRVKEA VRISNKLKHS PKVFSYWWYV YQDETNTFLT 300
ETDVKKTFQE IVINGGDGII IWGSSSDVNS LSKCTRLREY LLTVLGPIAV 350
NVTEAVN 357
Length:357
Mass (Da):41,948
Last modified:May 3, 2011 - v2
Checksum:i709A79B50DEE9A53
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1601R → P AA sequence 1 Publication
Sequence conflicti172 – 1721E → G AA sequence 1 Publication
Sequence conflicti314 – 3141N → S AA sequence 1 Publication
Sequence conflicti335 – 3351T → M AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR749885 mRNA. Translation: CBY83816.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR749885 mRNA. Translation: CBY83816.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 9454. Vesp ma 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR001329. Venom_Hyaluronidase.
[Graphical view ]
PANTHERi PTHR11769. PTHR11769. 1 hit.
Pfami PF01630. Glyco_hydro_56. 1 hit.
[Graphical view ]
PRINTSi PR00846. GLHYDRLASE56.
PR00847. HYALURONDASE.
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Purification and characterization of two new allergens from the venom of Vespa magnifica."
    An S., Chen L., Wei J.F., Yang X., Ma D., Xu X., Xu X., He S., Lu J., Lai R.
    PLoS ONE 7:E31920-E31920(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 27-54; 73-91; 125-135; 200-220; 283-304 AND 339-357, SUBCELLULAR LOCATION, ALLERGEN.
    Tissue: Venom and Venom gland.

Entry informationi

Entry nameiHUGA_VESMG
AccessioniPrimary (citable) accession number: P86875
Secondary accession number(s): E7BBB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: May 3, 2011
Last modified: December 11, 2013
This is version 13 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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