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Physalaemus signifer (Girard's dwarf frog)
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli


Produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle (By similarity). May target bradykinin receptors (BDKRB).By similarity

GO - Molecular functioni

GO - Biological processi


Molecular functionAmphibian defense peptide, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

Names & Taxonomyi

Protein namesi
Recommended name:
[Ala1,Thr6]-bradykinyl-Ser,Lys1 Publication
OrganismiPhysalaemus signifer (Girard's dwarf frog)
Taxonomic identifieri364768 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaLeptodactylidaeLeiuperinaePhysalaemus

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti


PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00004046891 – 11[Ala1,Thr6]-bradykinyl-Ser,Lys1 PublicationAdd BLAST11


Tissue specificityi

Expressed by the skin glands.1 Publication


GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the bradykinin-related peptide family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR009608. Bradykinin.
PfamiView protein in Pfam
PF06753. Bradykinin. 1 hit.


Sequence statusi: Complete.

Mass (Da):1,204
Last modified:February 8, 2011 - v1

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiBRK4_PHYSG
AccessioniPrimary (citable) accession number: P86814
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 10, 2017
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program


Keywords - Technical termi

Direct protein sequencing


  1. SIMILARITY comments
    Index of protein domains and families