ID   CC21C_MOUSE             Reviewed;         133 AA.
AC   P86793; O09002; O09006; P84443; Q5M8M5; Q91V84;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 1.
DT   27-MAR-2024, entry version 91.
DE   RecName: Full=C-C motif chemokine 21c;
DE   AltName: Full=6Ckine;
DE   AltName: Full=Beta-chemokine exodus-2;
DE   AltName: Full=Small-inducible cytokine A21c;
DE   AltName: Full=Thymus-derived chemotactic agent 4;
DE            Short=TCA4;
DE   Flags: Precursor;
GN   Name=Ccl21c; Synonyms=Scya21c;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=129/Ola;
RX   PubMed=11123313; DOI=10.4049/jimmunol.166.1.361;
RA   Nakano H., Gunn M.D.;
RT   "Gene duplications at the chemokine locus on mouse chromosome 4: multiple
RT   strain-specific haplotypes and the deletion of secondary lymphoid-organ
RT   chemokine and EBI-1 ligand chemokine genes in the plt mutation.";
RL   J. Immunol. 166:361-369(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   CHARACTERIZATION.
RX   PubMed=9419363; DOI=10.1073/pnas.95.1.258;
RA   Gunn M.D., Tangemann K., Tam C., Cyster J.G., Rosen S.D., Williams L.T.;
RT   "A chemokine expressed in lymphoid high endothelial venules promotes the
RT   adhesion and chemotaxis of naive T lymphocytes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:258-263(1998).
CC   -!- FUNCTION: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic
CC       in vitro for thymocytes and activated T-cells, but not for B-cells,
CC       macrophages, or neutrophils. Potent mesangial cell chemoattractant.
CC       Shows preferential activity towards naive T-cells. May play a role in
CC       mediating homing of lymphocytes to secondary lymphoid organs.
CC   -!- SUBUNIT: Binds to CCR7 and to CXCR3. Interacts with PDPN; relocalizes
CC       PDPN to the basolateral membrane. Interacts with GPR174.
CC       {ECO:0000250|UniProtKB:O00585, ECO:0000250|UniProtKB:P84444}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed strongly in lung, spleen, thymus,
CC       peripheral and mesentric lymph nodes. Also expressed in the testis,
CC       kidney, liver, and heart.
CC   -!- MISCELLANEOUS: Three genes code for Ccl21 in mouse. Ccl21b and Ccl21c
CC       produce identical proteins while the protein produced by Ccl21a differs
CC       at only one position. Ccl21b and Ccl21c have Leu-65 (6Ckine-Leu) while
CC       Ccl21a has 'Ser-65' (6Ckine-Ser).
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; AF307987; AAG45835.1; -; Genomic_DNA.
DR   EMBL; AL844494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC087957; AAH87957.1; -; mRNA.
DR   RefSeq; NP_001180595.1; NM_001193666.1.
DR   RefSeq; NP_001180597.1; NM_001193668.1.
DR   RefSeq; NP_001257289.1; NM_001270360.1.
DR   RefSeq; NP_035465.2; NM_011335.2.
DR   RefSeq; NP_075539.1; NM_023052.2.
DR   RefSeq; XP_001473308.1; XM_001473258.5.
DR   RefSeq; XP_001473444.1; XM_001473394.6.
DR   AlphaFoldDB; P86793; -.
DR   SMR; P86793; -.
DR   PhosphoSitePlus; P86793; -.
DR   jPOST; P86793; -.
DR   MaxQB; P86793; -.
DR   ProteomicsDB; 265588; -.
DR   DNASU; 65956; -.
DR   Ensembl; ENSMUST00000098123.4; ENSMUSP00000095727.4; ENSMUSG00000073878.4.
DR   Ensembl; ENSMUST00000098128.4; ENSMUSP00000095732.4; ENSMUSG00000094065.2.
DR   Ensembl; ENSMUST00000178168.3; ENSMUSP00000136903.2; ENSMUSG00000096596.3.
DR   Ensembl; ENSMUST00000178864.3; ENSMUSP00000137149.2; ENSMUSG00000095675.3.
DR   GeneID; 100042493; -.
DR   GeneID; 100504239; -.
DR   GeneID; 100504346; -.
DR   GeneID; 100862177; -.
DR   KEGG; mmu:100042493; -.
DR   KEGG; mmu:100504239; -.
DR   KEGG; mmu:100504346; -.
DR   KEGG; mmu:100862177; -.
DR   AGR; MGI:1891386; -.
DR   CTD; 100042493; -.
DR   CTD; 100862177; -.
DR   MGI; MGI:1891386; Ccl21c.
DR   VEuPathDB; HostDB:ENSMUSG00000073878; -.
DR   VEuPathDB; HostDB:ENSMUSG00000094065; -.
DR   VEuPathDB; HostDB:ENSMUSG00000094121; -.
DR   VEuPathDB; HostDB:ENSMUSG00000095675; -.
DR   VEuPathDB; HostDB:ENSMUSG00000096271; -.
DR   VEuPathDB; HostDB:ENSMUSG00000096596; -.
DR   VEuPathDB; HostDB:ENSMUSG00000096873; -.
DR   GeneTree; ENSGT01100000263557; -.
DR   HOGENOM; CLU_141716_3_2_1; -.
DR   InParanoid; P86793; -.
DR   OMA; SDCCLKH; -.
DR   OrthoDB; 5265378at2759; -.
DR   PhylomeDB; P86793; -.
DR   TreeFam; TF338224; -.
DR   BioGRID-ORCS; 100042493; 4 hits in 37 CRISPR screens.
DR   BioGRID-ORCS; 100504239; 0 hits in 11 CRISPR screens.
DR   BioGRID-ORCS; 100504346; 0 hits in 12 CRISPR screens.
DR   BioGRID-ORCS; 100862177; 2 hits in 23 CRISPR screens.
DR   BioGRID-ORCS; 65956; 0 hits in 4 CRISPR screens.
DR   PRO; PR:P86793; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; P86793; Protein.
DR   Bgee; ENSMUSG00000073878; Expressed in urinary bladder and 29 other cell types or tissues.
DR   ExpressionAtlas; P86793; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0071346; P:cellular response to type II interferon; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   Gene3D; 2.40.50.40; -; 1.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015:SF72; C-C MOTIF CHEMOKINE 21; 1.
DR   PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
DR   Genevisible; P86793; MM.
PE   1: Evidence at protein level;
KW   Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..133
FT                   /note="C-C motif chemokine 21c"
FT                   /id="PRO_0000403422"
FT   REGION          87..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          98..133
FT                   /note="C-terminal basic extension"
FT   DISULFID        31..57
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..75
FT                   /evidence="ECO:0000250"
FT   DISULFID        103..122
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   133 AA;  14584 MW;  7071750A2089A70B CRC64;
     MAQMMTLSLL SLVLALCIPW TQGSDGGGQD CCLKYSQKKI PYSIVRGYRK QEPSLGCPIP
     AILFLPRKHS KPELCANPEE GWVQNLMRRL DQPPAPGKQS PGCRKNRGTS KSGKKGKGSK
     GCKRTEQTQP SRG
//