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P86793

- CC21C_MOUSE

UniProt

P86793 - CC21C_MOUSE

Protein

C-C motif chemokine 21c

Gene

Ccl21c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs.

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 21c
    Alternative name(s):
    6Ckine
    Beta-chemokine exodus-2
    Small-inducible cytokine A21c
    Thymus-derived chemotactic agent 4
    Short name:
    TCA4
    Gene namesi
    Name:Ccl21c
    Synonyms:Scya21c
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1891386. Ccl21c.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 133110C-C motif chemokine 21cPRO_0000403422Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 57By similarity
    Disulfide bondi32 ↔ 75By similarity
    Disulfide bondi103 ↔ 122Sequence Analysis

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP86793.

    Expressioni

    Tissue specificityi

    Expressed strongly in lung, spleen, thymus, peripheral and mesentric lymph nodes. Also expressed in the testis, kidney, liver, and heart.

    Gene expression databases

    BgeeiP86793.
    GenevestigatoriP84443.

    Interactioni

    Subunit structurei

    Binds to CCR7 and to CXCR3.

    Protein-protein interaction databases

    MINTiMINT-123866.

    Structurei

    3D structure databases

    ProteinModelPortaliP86793.
    SMRiP86793. Positions 24-92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni98 – 13336C-terminal basic extensionAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    GeneTreeiENSGT00730000111297.
    KOiK16062.
    PhylomeDBiP86793.
    TreeFamiTF338224.

    Family and domain databases

    InterProiIPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P86793-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQMMTLSLL SLVLALCIPW TQGSDGGGQD CCLKYSQKKI PYSIVRGYRK    50
    QEPSLGCPIP AILFLPRKHS KPELCANPEE GWVQNLMRRL DQPPAPGKQS 100
    PGCRKNRGTS KSGKKGKGSK GCKRTEQTQP SRG 133
    Length:133
    Mass (Da):14,584
    Last modified:January 11, 2011 - v1
    Checksum:i7071750A2089A70B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF307987 Genomic DNA. Translation: AAG45835.1.
    AL844494 Genomic DNA. No translation available.
    BC087957 mRNA. Translation: AAH87957.1.
    RefSeqiNP_001180595.1. NM_001193666.1.
    NP_001180597.1. NM_001193668.1.
    NP_001257289.1. NM_001270360.1.
    NP_035465.2. NM_011335.2.
    NP_075539.1. NM_023052.2.
    XP_001473308.1. XM_001473258.4.
    XP_001473444.1. XM_001473394.4.
    UniGeneiMm.407493.

    Genome annotation databases

    EnsembliENSMUST00000098123; ENSMUSP00000095727; ENSMUSG00000073878.
    ENSMUST00000098128; ENSMUSP00000095732; ENSMUSG00000094065.
    ENSMUST00000177695; ENSMUSP00000136267; ENSMUSG00000094121.
    ENSMUST00000178081; ENSMUSP00000137398; ENSMUSG00000096873.
    ENSMUST00000178168; ENSMUSP00000136903; ENSMUSG00000096596.
    ENSMUST00000178765; ENSMUSP00000137555; ENSMUSG00000096271.
    ENSMUST00000178864; ENSMUSP00000137149; ENSMUSG00000095675.
    GeneIDi100041504.
    100041593.
    100042493.
    100504239.
    100504346.
    100862177.
    65956.
    KEGGimmu:100041504.
    mmu:100041593.
    mmu:100042493.
    mmu:100504239.
    mmu:100504346.
    mmu:100862177.
    mmu:65956.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF307987 Genomic DNA. Translation: AAG45835.1 .
    AL844494 Genomic DNA. No translation available.
    BC087957 mRNA. Translation: AAH87957.1 .
    RefSeqi NP_001180595.1. NM_001193666.1.
    NP_001180597.1. NM_001193668.1.
    NP_001257289.1. NM_001270360.1.
    NP_035465.2. NM_011335.2.
    NP_075539.1. NM_023052.2.
    XP_001473308.1. XM_001473258.4.
    XP_001473444.1. XM_001473394.4.
    UniGenei Mm.407493.

    3D structure databases

    ProteinModelPortali P86793.
    SMRi P86793. Positions 24-92.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-123866.

    Proteomic databases

    PRIDEi P86793.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000098123 ; ENSMUSP00000095727 ; ENSMUSG00000073878 .
    ENSMUST00000098128 ; ENSMUSP00000095732 ; ENSMUSG00000094065 .
    ENSMUST00000177695 ; ENSMUSP00000136267 ; ENSMUSG00000094121 .
    ENSMUST00000178081 ; ENSMUSP00000137398 ; ENSMUSG00000096873 .
    ENSMUST00000178168 ; ENSMUSP00000136903 ; ENSMUSG00000096596 .
    ENSMUST00000178765 ; ENSMUSP00000137555 ; ENSMUSG00000096271 .
    ENSMUST00000178864 ; ENSMUSP00000137149 ; ENSMUSG00000095675 .
    GeneIDi 100041504.
    100041593.
    100042493.
    100504239.
    100504346.
    100862177.
    65956.
    KEGGi mmu:100041504.
    mmu:100041593.
    mmu:100042493.
    mmu:100504239.
    mmu:100504346.
    mmu:100862177.
    mmu:65956.

    Organism-specific databases

    CTDi 100042493.
    65956.
    MGIi MGI:1891386. Ccl21c.

    Phylogenomic databases

    GeneTreei ENSGT00730000111297.
    KOi K16062.
    PhylomeDBi P86793.
    TreeFami TF338224.

    Miscellaneous databases

    NextBioi 320370.
    PROi P86793.
    SOURCEi Search...

    Gene expression databases

    Bgeei P86793.
    Genevestigatori P84443.

    Family and domain databases

    InterProi IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation."
      Nakano H., Gunn M.D.
      J. Immunol. 166:361-369(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Ola.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.
    4. "A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes."
      Gunn M.D., Tangemann K., Tam C., Cyster J.G., Rosen S.D., Williams L.T.
      Proc. Natl. Acad. Sci. U.S.A. 95:258-263(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiCC21C_MOUSE
    AccessioniPrimary (citable) accession number: P86793
    Secondary accession number(s): O09002
    , O09006, P84443, Q5M8M5, Q91V84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2011
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Three genes code for Ccl21 in mouse. Ccl21b and Ccl21c produce identical proteins while the protein produced by Ccl21a differs at only one position. Ccl21b and Ccl21c have Leu-65 (6Ckine-Leu) while Ccl21a has 'Ser-65' (6Ckine-Ser).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3