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Protein

C-C motif chemokine 21c

Gene

Ccl21c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs.

Miscellaneous

Three genes code for Ccl21 in mouse. Ccl21b and Ccl21c produce identical proteins while the protein produced by Ccl21a differs at only one position. Ccl21b and Ccl21c have Leu-65 (6Ckine-Leu) while Ccl21a has 'Ser-65' (6Ckine-Ser).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 21c
Alternative name(s):
6Ckine
Beta-chemokine exodus-2
Small-inducible cytokine A21c
Thymus-derived chemotactic agent 4
Short name:
TCA4
Gene namesi
Name:Ccl21c
Synonyms:Scya21c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1891386 Ccl21c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000040342224 – 133C-C motif chemokine 21cAdd BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 57By similarity
Disulfide bondi32 ↔ 75By similarity
Disulfide bondi103 ↔ 122Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP86793
PRIDEiP86793

PTM databases

PhosphoSitePlusiP86793

Expressioni

Tissue specificityi

Expressed strongly in lung, spleen, thymus, peripheral and mesentric lymph nodes. Also expressed in the testis, kidney, liver, and heart.

Gene expression databases

BgeeiENSMUSG00000073878
ExpressionAtlasiP86793 baseline
GenevisibleiP86793 MM

Interactioni

Subunit structurei

Binds to CCR7 and to CXCR3. Interacts with PDPN; relocalizes PDPN to the basolateral membrane.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP86793
SMRiP86793
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 133C-terminal basic extensionAdd BLAST36

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3QM Eukaryota
ENOG410Z7F2 LUCA
GeneTreeiENSGT00730000111297
KOiK16062
OrthoDBiEOG091G14NY
PhylomeDBiP86793
TreeFamiTF338224

Family and domain databases

InterProiView protein in InterPro
IPR030593 CCL21
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015:SF72 PTHR12015:SF72, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P86793-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQMMTLSLL SLVLALCIPW TQGSDGGGQD CCLKYSQKKI PYSIVRGYRK
60 70 80 90 100
QEPSLGCPIP AILFLPRKHS KPELCANPEE GWVQNLMRRL DQPPAPGKQS
110 120 130
PGCRKNRGTS KSGKKGKGSK GCKRTEQTQP SRG
Length:133
Mass (Da):14,584
Last modified:January 11, 2011 - v1
Checksum:i7071750A2089A70B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF307987 Genomic DNA Translation: AAG45835.1
AL844494 Genomic DNA No translation available.
BC087957 mRNA Translation: AAH87957.1
RefSeqiNP_001180595.1, NM_001193666.1
NP_001180597.1, NM_001193668.1
NP_001257289.1, NM_001270360.1
NP_035465.2, NM_011335.2
NP_075539.1, NM_023052.2
XP_001473308.1, XM_001473258.5
XP_001473444.1, XM_001473394.6
UniGeneiMm.407493

Genome annotation databases

EnsembliENSMUST00000098123; ENSMUSP00000095727; ENSMUSG00000073878
ENSMUST00000098128; ENSMUSP00000095732; ENSMUSG00000094065
ENSMUST00000177695; ENSMUSP00000136267; ENSMUSG00000094121
ENSMUST00000178081; ENSMUSP00000137398; ENSMUSG00000096873
ENSMUST00000178168; ENSMUSP00000136903; ENSMUSG00000096596
ENSMUST00000178765; ENSMUSP00000137555; ENSMUSG00000096271
ENSMUST00000178864; ENSMUSP00000137149; ENSMUSG00000095675
GeneIDi100041504
100041593
100042493
100504239
100504346
100862177
65956
KEGGimmu:100041504
mmu:100041593
mmu:100042493
mmu:100504239
mmu:100504346
mmu:100862177
mmu:65956

Similar proteinsi

Entry informationi

Entry nameiCC21C_MOUSE
AccessioniPrimary (citable) accession number: P86793
Secondary accession number(s): O09002
, O09006, P84443, Q5M8M5, Q91V84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: January 11, 2011
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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