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P86793 (CC21C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 21c
Alternative name(s):
6Ckine
Beta-chemokine exodus-2
Small-inducible cytokine A21c
Thymus-derived chemotactic agent 4
Short name=TCA4
Gene names
Name:Ccl21c
Synonyms:Scya21c
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length133 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs.

Subunit structure

Binds to CCR7 and to CXCR3.

Subcellular location

Secreted.

Tissue specificity

Expressed strongly in lung, spleen, thymus, peripheral and mesentric lymph nodes. Also expressed in the testis, kidney, liver, and heart.

Miscellaneous

Three genes code for Ccl21 in mouse. Ccl21b and Ccl21c produce identical proteins while the protein produced by Ccl21a differs at only one position. Ccl21b and Ccl21c have Leu-65 (6Ckine-Leu) while Ccl21a has 'Ser-65' (6Ckine-Ser).

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 133110C-C motif chemokine 21c
PRO_0000403422

Regions

Region98 – 13336C-terminal basic extension

Amino acid modifications

Disulfide bond31 ↔ 57 By similarity
Disulfide bond32 ↔ 75 By similarity
Disulfide bond103 ↔ 122 Potential

Sequences

Sequence LengthMass (Da)Tools
P86793 [UniParc].

Last modified January 11, 2011. Version 1.
Checksum: 7071750A2089A70B

FASTA13314,584
        10         20         30         40         50         60 
MAQMMTLSLL SLVLALCIPW TQGSDGGGQD CCLKYSQKKI PYSIVRGYRK QEPSLGCPIP 

        70         80         90        100        110        120 
AILFLPRKHS KPELCANPEE GWVQNLMRRL DQPPAPGKQS PGCRKNRGTS KSGKKGKGSK 

       130 
GCKRTEQTQP SRG 

« Hide

References

« Hide 'large scale' references
[1]"Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation."
Nakano H., Gunn M.D.
J. Immunol. 166:361-369(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Ola.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
[4]"A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes."
Gunn M.D., Tangemann K., Tam C., Cyster J.G., Rosen S.D., Williams L.T.
Proc. Natl. Acad. Sci. U.S.A. 95:258-263(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF307987 Genomic DNA. Translation: AAG45835.1.
AL844494 Genomic DNA. No translation available.
BC087957 mRNA. Translation: AAH87957.1.
RefSeqNP_001180595.1. NM_001193666.1.
NP_001180597.1. NM_001193668.1.
NP_001257289.1. NM_001270360.1.
NP_035465.2. NM_011335.2.
NP_075539.1. NM_023052.2.
XP_001473308.1. XM_001473258.4.
XP_001473444.1. XM_001473394.4.
UniGeneMm.407493.

3D structure databases

ProteinModelPortalP86793.
SMRP86793. Positions 24-92.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-123866.

Proteomic databases

PRIDEP86793.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000098123; ENSMUSP00000095727; ENSMUSG00000073878.
ENSMUST00000098128; ENSMUSP00000095732; ENSMUSG00000094065.
ENSMUST00000177695; ENSMUSP00000136267; ENSMUSG00000094121.
ENSMUST00000178081; ENSMUSP00000137398; ENSMUSG00000096873.
ENSMUST00000178168; ENSMUSP00000136903; ENSMUSG00000096596.
ENSMUST00000178765; ENSMUSP00000137555; ENSMUSG00000096271.
ENSMUST00000178864; ENSMUSP00000137149; ENSMUSG00000095675.
GeneID100041504.
100041593.
100042493.
100504239.
100504346.
100862177.
65956.
KEGGmmu:100041504.
mmu:100041593.
mmu:100042493.
mmu:100504239.
mmu:100504346.
mmu:100862177.
mmu:65956.

Organism-specific databases

CTD100042493.
65956.
MGIMGI:1891386. Ccl21c.

Phylogenomic databases

GeneTreeENSGT00730000111297.
KOK16062.
PhylomeDBP86793.
TreeFamTF338224.

Gene expression databases

BgeeP86793.
GenevestigatorP84443.

Family and domain databases

InterProIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
ProtoNetSearch...

Other

NextBio320370.
PROP86793.
SOURCESearch...

Entry information

Entry nameCC21C_MOUSE
AccessionPrimary (citable) accession number: P86793
Secondary accession number(s): O09002 expand/collapse secondary AC list , O09006, P84443, Q5M8M5, Q91V84
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot