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P86793

- CC21C_MOUSE

UniProt

P86793 - CC21C_MOUSE

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Protein

C-C motif chemokine 21c

Gene

Ccl21c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs.

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_230248. Chemokine receptors bind chemokines.
REACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 21c
Alternative name(s):
6Ckine
Beta-chemokine exodus-2
Small-inducible cytokine A21c
Thymus-derived chemotactic agent 4
Short name:
TCA4
Gene namesi
Name:Ccl21c
Synonyms:Scya21c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4, UP000000589: Unplaced

Organism-specific databases

MGIiMGI:1891386. Ccl21c.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 133110C-C motif chemokine 21cPRO_0000403422Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 57By similarity
Disulfide bondi32 ↔ 75By similarity
Disulfide bondi103 ↔ 122Sequence Analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP86793.

Expressioni

Tissue specificityi

Expressed strongly in lung, spleen, thymus, peripheral and mesentric lymph nodes. Also expressed in the testis, kidney, liver, and heart.

Gene expression databases

BgeeiP86793.
ExpressionAtlasiP86793. baseline.
GenevestigatoriP84443.

Interactioni

Subunit structurei

Binds to CCR7 and to CXCR3.

Protein-protein interaction databases

MINTiMINT-123866.

Structurei

3D structure databases

ProteinModelPortaliP86793.
SMRiP86793. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni98 – 13336C-terminal basic extensionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00730000111297.
KOiK16062.
PhylomeDBiP86793.
TreeFamiTF338224.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P86793-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQMMTLSLL SLVLALCIPW TQGSDGGGQD CCLKYSQKKI PYSIVRGYRK
60 70 80 90 100
QEPSLGCPIP AILFLPRKHS KPELCANPEE GWVQNLMRRL DQPPAPGKQS
110 120 130
PGCRKNRGTS KSGKKGKGSK GCKRTEQTQP SRG
Length:133
Mass (Da):14,584
Last modified:January 11, 2011 - v1
Checksum:i7071750A2089A70B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF307987 Genomic DNA. Translation: AAG45835.1.
AL844494 Genomic DNA. No translation available.
BC087957 mRNA. Translation: AAH87957.1.
RefSeqiNP_001180595.1. NM_001193666.1.
NP_001180597.1. NM_001193668.1.
NP_001257289.1. NM_001270360.1.
NP_035465.2. NM_011335.2.
NP_075539.1. NM_023052.2.
XP_001473308.1. XM_001473258.4.
XP_001473444.1. XM_001473394.4.
UniGeneiMm.407493.

Genome annotation databases

EnsembliENSMUST00000098123; ENSMUSP00000095727; ENSMUSG00000073878.
ENSMUST00000098128; ENSMUSP00000095732; ENSMUSG00000094065.
ENSMUST00000177695; ENSMUSP00000136267; ENSMUSG00000094121.
ENSMUST00000178081; ENSMUSP00000137398; ENSMUSG00000096873.
ENSMUST00000178168; ENSMUSP00000136903; ENSMUSG00000096596.
ENSMUST00000178765; ENSMUSP00000137555; ENSMUSG00000096271.
ENSMUST00000178864; ENSMUSP00000137149; ENSMUSG00000095675.
GeneIDi100041504.
100041593.
100042493.
100504239.
100504346.
100862177.
65956.
KEGGimmu:100041504.
mmu:100041593.
mmu:100042493.
mmu:100504239.
mmu:100504346.
mmu:100862177.
mmu:65956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF307987 Genomic DNA. Translation: AAG45835.1 .
AL844494 Genomic DNA. No translation available.
BC087957 mRNA. Translation: AAH87957.1 .
RefSeqi NP_001180595.1. NM_001193666.1.
NP_001180597.1. NM_001193668.1.
NP_001257289.1. NM_001270360.1.
NP_035465.2. NM_011335.2.
NP_075539.1. NM_023052.2.
XP_001473308.1. XM_001473258.4.
XP_001473444.1. XM_001473394.4.
UniGenei Mm.407493.

3D structure databases

ProteinModelPortali P86793.
SMRi P86793. Positions 24-92.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-123866.

Proteomic databases

PRIDEi P86793.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000098123 ; ENSMUSP00000095727 ; ENSMUSG00000073878 .
ENSMUST00000098128 ; ENSMUSP00000095732 ; ENSMUSG00000094065 .
ENSMUST00000177695 ; ENSMUSP00000136267 ; ENSMUSG00000094121 .
ENSMUST00000178081 ; ENSMUSP00000137398 ; ENSMUSG00000096873 .
ENSMUST00000178168 ; ENSMUSP00000136903 ; ENSMUSG00000096596 .
ENSMUST00000178765 ; ENSMUSP00000137555 ; ENSMUSG00000096271 .
ENSMUST00000178864 ; ENSMUSP00000137149 ; ENSMUSG00000095675 .
GeneIDi 100041504.
100041593.
100042493.
100504239.
100504346.
100862177.
65956.
KEGGi mmu:100041504.
mmu:100041593.
mmu:100042493.
mmu:100504239.
mmu:100504346.
mmu:100862177.
mmu:65956.

Organism-specific databases

CTDi 100042493.
65956.
MGIi MGI:1891386. Ccl21c.

Phylogenomic databases

GeneTreei ENSGT00730000111297.
KOi K16062.
PhylomeDBi P86793.
TreeFami TF338224.

Enzyme and pathway databases

Reactomei REACT_230248. Chemokine receptors bind chemokines.
REACT_250376. G alpha (i) signalling events.

Miscellaneous databases

NextBioi 320370.
PROi P86793.
SOURCEi Search...

Gene expression databases

Bgeei P86793.
ExpressionAtlasi P86793. baseline.
Genevestigatori P84443.

Family and domain databases

InterProi IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation."
    Nakano H., Gunn M.D.
    J. Immunol. 166:361-369(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Ola.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  4. "A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes."
    Gunn M.D., Tangemann K., Tam C., Cyster J.G., Rosen S.D., Williams L.T.
    Proc. Natl. Acad. Sci. U.S.A. 95:258-263(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiCC21C_MOUSE
AccessioniPrimary (citable) accession number: P86793
Secondary accession number(s): O09002
, O09006, P84443, Q5M8M5, Q91V84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: January 11, 2011
Last modified: November 26, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Three genes code for Ccl21 in mouse. Ccl21b and Ccl21c produce identical proteins while the protein produced by Ccl21a differs at only one position. Ccl21b and Ccl21c have Leu-65 (6Ckine-Leu) while Ccl21a has 'Ser-65' (6Ckine-Ser).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3