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P86792 (CC21B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 21b
Alternative name(s):
6Ckine
Beta-chemokine exodus-2
Small-inducible cytokine A21b
Thymus-derived chemotactic agent 4
Short name=TCA4
Gene names
Name:Ccl21b
Synonyms:Scya21, Scya21b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length133 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs.

Subunit structure

Binds to CCR7 and to CXCR3.

Subcellular location

Secreted.

Tissue specificity

Expressed strongly in lung, spleen, thymus, peripheral and mesentric lymph nodes. Also expressed in the testis, kidney, liver, and heart.

Miscellaneous

Three genes code for Ccl21 in mouse. Ccl21b and Ccl21c produce identical proteins while the protein produced by Ccl21a differs at only one position. Ccl21b and Ccl21c have Leu-65 (6Ckine-Leu) while Ccl21a has 'Ser-65' (6Ckine-Ser).

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 133110C-C motif chemokine 21b
PRO_0000005222

Regions

Region98 – 13336C-terminal basic extension

Amino acid modifications

Disulfide bond31 ↔ 57 By similarity
Disulfide bond32 ↔ 75 By similarity
Disulfide bond103 ↔ 122 Potential

Experimental info

Sequence conflict131V → D in AAC17929. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P86792 [UniParc].

Last modified January 11, 2011. Version 1.
Checksum: 7071750A2089A70B

FASTA13314,584
        10         20         30         40         50         60 
MAQMMTLSLL SLVLALCIPW TQGSDGGGQD CCLKYSQKKI PYSIVRGYRK QEPSLGCPIP 

        70         80         90        100        110        120 
AILFLPRKHS KPELCANPEE GWVQNLMRRL DQPPAPGKQS PGCRKNRGTS KSGKKGKGSK 

       130 
GCKRTEQTQP SRG 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension."
Hromas R., Kim C.H., Klemsz M., Krathwohl M., Fife K., Cooper S., Schnizlein-Bick C., Broxmeyer H.E.
J. Immunol. 159:2554-2558(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetus.
[2]"The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genes."
Vassileva G., Soto H., Zlotnik A., Nakano H., Kakiuchi T., Hedrick J.A., Lira S.A.
J. Exp. Med. 190:1183-1188(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
Tissue: Embryonic stem cell.
[3]"Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation."
Nakano H., Gunn M.D.
J. Immunol. 166:361-369(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Ola.
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[5]"A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes."
Gunn M.D., Tangemann K., Tam C., Cyster J.G., Rosen S.D., Williams L.T.
Proc. Natl. Acad. Sci. U.S.A. 95:258-263(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U88322 mRNA. Translation: AAC17929.1.
AF171085 Genomic DNA. Translation: AAF16900.1.
AF307986 Genomic DNA. Translation: AAG45834.1.
AL824709 Genomic DNA. Translation: CAM22843.1.
CCDSCCDS51145.1.
RefSeqNP_001180595.1. NM_001193666.1.
NP_001180597.1. NM_001193668.1.
NP_001257289.1. NM_001270360.1.
NP_035465.2. NM_011335.2.
NP_075539.1. NM_023052.2.
XP_001473308.1. XM_001473258.4.
XP_001473444.1. XM_001473394.4.
UniGeneMm.407493.

3D structure databases

ProteinModelPortalP86792.
SMRP86792. Positions 24-92.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP86792.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000098123; ENSMUSP00000095727; ENSMUSG00000073878.
ENSMUST00000098128; ENSMUSP00000095732; ENSMUSG00000094065.
ENSMUST00000177695; ENSMUSP00000136267; ENSMUSG00000094121.
ENSMUST00000178081; ENSMUSP00000137398; ENSMUSG00000096873.
ENSMUST00000178168; ENSMUSP00000136903; ENSMUSG00000096596.
ENSMUST00000178765; ENSMUSP00000137555; ENSMUSG00000096271.
ENSMUST00000178864; ENSMUSP00000137149; ENSMUSG00000095675.
GeneID100041504.
100041593.
100042493.
100504239.
100504346.
100862177.
65956.
KEGGmmu:100041504.
mmu:100041593.
mmu:100042493.
mmu:100504239.
mmu:100504346.
mmu:100862177.
mmu:65956.
UCSCuc008skt.1. mouse.

Organism-specific databases

CTD100042493.
65956.
MGIMGI:1349182. Ccl21b.

Phylogenomic databases

HOGENOMHOG000036685.
KOK16062.
OrthoDBEOG7GXPDG.
PhylomeDBP86792.

Gene expression databases

BgeeP86792.
GenevestigatorP84443.

Family and domain databases

InterProIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
ProtoNetSearch...

Other

NextBio320370.
PROP86792.
SOURCESearch...

Entry information

Entry nameCC21B_MOUSE
AccessionPrimary (citable) accession number: P86792
Secondary accession number(s): O09002 expand/collapse secondary AC list , O09006, P84443, Q5M8M5, Q91V84
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot