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P86792

- CC21B_MOUSE

UniProt

P86792 - CC21B_MOUSE

Protein

C-C motif chemokine 21b

Gene

Ccl21b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs.

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 21b
    Alternative name(s):
    6Ckine
    Beta-chemokine exodus-2
    Small-inducible cytokine A21b
    Thymus-derived chemotactic agent 4
    Short name:
    TCA4
    Gene namesi
    Name:Ccl21b
    Synonyms:Scya21, Scya21b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1349182. Ccl21b.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 133110C-C motif chemokine 21bPRO_0000005222Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 57By similarity
    Disulfide bondi32 ↔ 75By similarity
    Disulfide bondi103 ↔ 122Sequence Analysis

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP86792.

    Expressioni

    Tissue specificityi

    Expressed strongly in lung, spleen, thymus, peripheral and mesentric lymph nodes. Also expressed in the testis, kidney, liver, and heart.

    Gene expression databases

    BgeeiP86792.
    GenevestigatoriP84443.

    Interactioni

    Subunit structurei

    Binds to CCR7 and to CXCR3.

    Structurei

    3D structure databases

    ProteinModelPortaliP86792.
    SMRiP86792. Positions 24-92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni98 – 13336C-terminal basic extensionAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOGENOMiHOG000036685.
    KOiK16062.
    OrthoDBiEOG7GXPDG.
    PhylomeDBiP86792.

    Family and domain databases

    InterProiIPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P86792-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQMMTLSLL SLVLALCIPW TQGSDGGGQD CCLKYSQKKI PYSIVRGYRK    50
    QEPSLGCPIP AILFLPRKHS KPELCANPEE GWVQNLMRRL DQPPAPGKQS 100
    PGCRKNRGTS KSGKKGKGSK GCKRTEQTQP SRG 133
    Length:133
    Mass (Da):14,584
    Last modified:January 11, 2011 - v1
    Checksum:i7071750A2089A70B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti13 – 131V → D in AAC17929. (PubMed:9300671)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U88322 mRNA. Translation: AAC17929.1.
    AF171085 Genomic DNA. Translation: AAF16900.1.
    AF307986 Genomic DNA. Translation: AAG45834.1.
    AL824709 Genomic DNA. Translation: CAM22843.1.
    CCDSiCCDS51145.1.
    RefSeqiNP_001180595.1. NM_001193666.1.
    NP_001180597.1. NM_001193668.1.
    NP_001257289.1. NM_001270360.1.
    NP_035465.2. NM_011335.2.
    NP_075539.1. NM_023052.2.
    XP_001473308.1. XM_001473258.4.
    XP_001473444.1. XM_001473394.4.
    UniGeneiMm.407493.

    Genome annotation databases

    EnsembliENSMUST00000098123; ENSMUSP00000095727; ENSMUSG00000073878.
    ENSMUST00000098128; ENSMUSP00000095732; ENSMUSG00000094065.
    ENSMUST00000177695; ENSMUSP00000136267; ENSMUSG00000094121.
    ENSMUST00000178081; ENSMUSP00000137398; ENSMUSG00000096873.
    ENSMUST00000178168; ENSMUSP00000136903; ENSMUSG00000096596.
    ENSMUST00000178765; ENSMUSP00000137555; ENSMUSG00000096271.
    ENSMUST00000178864; ENSMUSP00000137149; ENSMUSG00000095675.
    GeneIDi100041504.
    100041593.
    100042493.
    100504239.
    100504346.
    100862177.
    65956.
    KEGGimmu:100041504.
    mmu:100041593.
    mmu:100042493.
    mmu:100504239.
    mmu:100504346.
    mmu:100862177.
    mmu:65956.
    UCSCiuc008skt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U88322 mRNA. Translation: AAC17929.1 .
    AF171085 Genomic DNA. Translation: AAF16900.1 .
    AF307986 Genomic DNA. Translation: AAG45834.1 .
    AL824709 Genomic DNA. Translation: CAM22843.1 .
    CCDSi CCDS51145.1.
    RefSeqi NP_001180595.1. NM_001193666.1.
    NP_001180597.1. NM_001193668.1.
    NP_001257289.1. NM_001270360.1.
    NP_035465.2. NM_011335.2.
    NP_075539.1. NM_023052.2.
    XP_001473308.1. XM_001473258.4.
    XP_001473444.1. XM_001473394.4.
    UniGenei Mm.407493.

    3D structure databases

    ProteinModelPortali P86792.
    SMRi P86792. Positions 24-92.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P86792.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000098123 ; ENSMUSP00000095727 ; ENSMUSG00000073878 .
    ENSMUST00000098128 ; ENSMUSP00000095732 ; ENSMUSG00000094065 .
    ENSMUST00000177695 ; ENSMUSP00000136267 ; ENSMUSG00000094121 .
    ENSMUST00000178081 ; ENSMUSP00000137398 ; ENSMUSG00000096873 .
    ENSMUST00000178168 ; ENSMUSP00000136903 ; ENSMUSG00000096596 .
    ENSMUST00000178765 ; ENSMUSP00000137555 ; ENSMUSG00000096271 .
    ENSMUST00000178864 ; ENSMUSP00000137149 ; ENSMUSG00000095675 .
    GeneIDi 100041504.
    100041593.
    100042493.
    100504239.
    100504346.
    100862177.
    65956.
    KEGGi mmu:100041504.
    mmu:100041593.
    mmu:100042493.
    mmu:100504239.
    mmu:100504346.
    mmu:100862177.
    mmu:65956.
    UCSCi uc008skt.1. mouse.

    Organism-specific databases

    CTDi 100042493.
    65956.
    MGIi MGI:1349182. Ccl21b.

    Phylogenomic databases

    HOGENOMi HOG000036685.
    KOi K16062.
    OrthoDBi EOG7GXPDG.
    PhylomeDBi P86792.

    Miscellaneous databases

    NextBioi 320370.
    PROi P86792.
    SOURCEi Search...

    Gene expression databases

    Bgeei P86792.
    Genevestigatori P84443.

    Family and domain databases

    InterProi IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension."
      Hromas R., Kim C.H., Klemsz M., Krathwohl M., Fife K., Cooper S., Schnizlein-Bick C., Broxmeyer H.E.
      J. Immunol. 159:2554-2558(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetus.
    2. "The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genes."
      Vassileva G., Soto H., Zlotnik A., Nakano H., Kakiuchi T., Hedrick J.A., Lira S.A.
      J. Exp. Med. 190:1183-1188(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
      Tissue: Embryonic stem cell.
    3. "Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation."
      Nakano H., Gunn M.D.
      J. Immunol. 166:361-369(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Ola.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes."
      Gunn M.D., Tangemann K., Tam C., Cyster J.G., Rosen S.D., Williams L.T.
      Proc. Natl. Acad. Sci. U.S.A. 95:258-263(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiCC21B_MOUSE
    AccessioniPrimary (citable) accession number: P86792
    Secondary accession number(s): O09002
    , O09006, P84443, Q5M8M5, Q91V84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2011
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Three genes code for Ccl21 in mouse. Ccl21b and Ccl21c produce identical proteins while the protein produced by Ccl21a differs at only one position. Ccl21b and Ccl21c have Leu-65 (6Ckine-Leu) while Ccl21a has 'Ser-65' (6Ckine-Ser).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3