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Protein

C-C motif chemokine 21b

Gene

Ccl21b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs.

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 21b
Alternative name(s):
6Ckine
Beta-chemokine exodus-2
Small-inducible cytokine A21b
Thymus-derived chemotactic agent 4
Short name:
TCA4
Gene namesi
Name:Ccl21b
Synonyms:Scya21, Scya21b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componentsi: Chromosome 4, Unplaced

Organism-specific databases

MGIiMGI:1349182. Ccl21b.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 133110C-C motif chemokine 21bPRO_0000005222Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 57By similarity
Disulfide bondi32 ↔ 75By similarity
Disulfide bondi103 ↔ 122Sequence Analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP86792.

Expressioni

Tissue specificityi

Expressed strongly in lung, spleen, thymus, peripheral and mesentric lymph nodes. Also expressed in the testis, kidney, liver, and heart.

Gene expression databases

BgeeiP86792.
ExpressionAtlasiP86792. baseline.
GenevestigatoriP84443.

Interactioni

Subunit structurei

Binds to CCR7 and to CXCR3.

Structurei

3D structure databases

ProteinModelPortaliP86792.
SMRiP86792. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni98 – 13336C-terminal basic extensionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000036685.
InParanoidiP86792.
KOiK16062.
OrthoDBiEOG7GXPDG.
PhylomeDBiP86792.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P86792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQMMTLSLL SLVLALCIPW TQGSDGGGQD CCLKYSQKKI PYSIVRGYRK
60 70 80 90 100
QEPSLGCPIP AILFLPRKHS KPELCANPEE GWVQNLMRRL DQPPAPGKQS
110 120 130
PGCRKNRGTS KSGKKGKGSK GCKRTEQTQP SRG
Length:133
Mass (Da):14,584
Last modified:January 11, 2011 - v1
Checksum:i7071750A2089A70B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131V → D in AAC17929 (PubMed:9300671).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88322 mRNA. Translation: AAC17929.1.
AF171085 Genomic DNA. Translation: AAF16900.1.
AF307986 Genomic DNA. Translation: AAG45834.1.
AL824709 Genomic DNA. Translation: CAM22843.1.
CCDSiCCDS51145.1.
RefSeqiNP_001180595.1. NM_001193666.1.
NP_001180597.1. NM_001193668.1.
NP_001257289.1. NM_001270360.1.
NP_035465.2. NM_011335.2.
NP_075539.1. NM_023052.2.
XP_001473308.1. XM_001473258.4.
XP_001473444.1. XM_001473394.5.
UniGeneiMm.407493.

Genome annotation databases

EnsembliENSMUST00000098123; ENSMUSP00000095727; ENSMUSG00000073878.
ENSMUST00000098128; ENSMUSP00000095732; ENSMUSG00000094065.
ENSMUST00000177695; ENSMUSP00000136267; ENSMUSG00000094121.
ENSMUST00000178081; ENSMUSP00000137398; ENSMUSG00000096873.
ENSMUST00000178168; ENSMUSP00000136903; ENSMUSG00000096596.
ENSMUST00000178765; ENSMUSP00000137555; ENSMUSG00000096271.
ENSMUST00000178864; ENSMUSP00000137149; ENSMUSG00000095675.
GeneIDi100041504.
100041593.
100042493.
100504239.
100504346.
100862177.
65956.
KEGGimmu:100041504.
mmu:100041593.
mmu:100042493.
mmu:100504239.
mmu:100504346.
mmu:100862177.
mmu:65956.
UCSCiuc008skt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88322 mRNA. Translation: AAC17929.1.
AF171085 Genomic DNA. Translation: AAF16900.1.
AF307986 Genomic DNA. Translation: AAG45834.1.
AL824709 Genomic DNA. Translation: CAM22843.1.
CCDSiCCDS51145.1.
RefSeqiNP_001180595.1. NM_001193666.1.
NP_001180597.1. NM_001193668.1.
NP_001257289.1. NM_001270360.1.
NP_035465.2. NM_011335.2.
NP_075539.1. NM_023052.2.
XP_001473308.1. XM_001473258.4.
XP_001473444.1. XM_001473394.5.
UniGeneiMm.407493.

3D structure databases

ProteinModelPortaliP86792.
SMRiP86792. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP86792.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098123; ENSMUSP00000095727; ENSMUSG00000073878.
ENSMUST00000098128; ENSMUSP00000095732; ENSMUSG00000094065.
ENSMUST00000177695; ENSMUSP00000136267; ENSMUSG00000094121.
ENSMUST00000178081; ENSMUSP00000137398; ENSMUSG00000096873.
ENSMUST00000178168; ENSMUSP00000136903; ENSMUSG00000096596.
ENSMUST00000178765; ENSMUSP00000137555; ENSMUSG00000096271.
ENSMUST00000178864; ENSMUSP00000137149; ENSMUSG00000095675.
GeneIDi100041504.
100041593.
100042493.
100504239.
100504346.
100862177.
65956.
KEGGimmu:100041504.
mmu:100041593.
mmu:100042493.
mmu:100504239.
mmu:100504346.
mmu:100862177.
mmu:65956.
UCSCiuc008skt.1. mouse.

Organism-specific databases

CTDi100042493.
65956.
MGIiMGI:1349182. Ccl21b.

Phylogenomic databases

HOGENOMiHOG000036685.
InParanoidiP86792.
KOiK16062.
OrthoDBiEOG7GXPDG.
PhylomeDBiP86792.

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Miscellaneous databases

NextBioi320370.
PROiP86792.
SOURCEiSearch...

Gene expression databases

BgeeiP86792.
ExpressionAtlasiP86792. baseline.
GenevestigatoriP84443.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension."
    Hromas R., Kim C.H., Klemsz M., Krathwohl M., Fife K., Cooper S., Schnizlein-Bick C., Broxmeyer H.E.
    J. Immunol. 159:2554-2558(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetus.
  2. "The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genes."
    Vassileva G., Soto H., Zlotnik A., Nakano H., Kakiuchi T., Hedrick J.A., Lira S.A.
    J. Exp. Med. 190:1183-1188(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
    Tissue: Embryonic stem cell.
  3. "Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation."
    Nakano H., Gunn M.D.
    J. Immunol. 166:361-369(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Ola.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes."
    Gunn M.D., Tangemann K., Tam C., Cyster J.G., Rosen S.D., Williams L.T.
    Proc. Natl. Acad. Sci. U.S.A. 95:258-263(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiCC21B_MOUSE
AccessioniPrimary (citable) accession number: P86792
Secondary accession number(s): O09002
, O09006, P84443, Q5M8M5, Q91V84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: January 11, 2011
Last modified: April 1, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Three genes code for Ccl21 in mouse. Ccl21b and Ccl21c produce identical proteins while the protein produced by Ccl21a differs at only one position. Ccl21b and Ccl21c have Leu-65 (6Ckine-Leu) while Ccl21a has 'Ser-65' (6Ckine-Ser).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.