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P86792

- CC21B_MOUSE

UniProt

P86792 - CC21B_MOUSE

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Protein

C-C motif chemokine 21b

Gene
Ccl21b, Scya21, Scya21b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs.

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 21b
Alternative name(s):
6Ckine
Beta-chemokine exodus-2
Small-inducible cytokine A21b
Thymus-derived chemotactic agent 4
Short name:
TCA4
Gene namesi
Name:Ccl21b
Synonyms:Scya21, Scya21b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1349182. Ccl21b.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 133110C-C motif chemokine 21bPRO_0000005222Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 57 By similarity
Disulfide bondi32 ↔ 75 By similarity
Disulfide bondi103 ↔ 122 Reviewed prediction

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP86792.

Expressioni

Tissue specificityi

Expressed strongly in lung, spleen, thymus, peripheral and mesentric lymph nodes. Also expressed in the testis, kidney, liver, and heart.

Gene expression databases

BgeeiP86792.
GenevestigatoriP84443.

Interactioni

Subunit structurei

Binds to CCR7 and to CXCR3.

Structurei

3D structure databases

ProteinModelPortaliP86792.
SMRiP86792. Positions 24-92.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni98 – 13336C-terminal basic extensionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000036685.
KOiK16062.
OrthoDBiEOG7GXPDG.
PhylomeDBiP86792.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P86792-1 [UniParc]FASTAAdd to Basket

« Hide

MAQMMTLSLL SLVLALCIPW TQGSDGGGQD CCLKYSQKKI PYSIVRGYRK    50
QEPSLGCPIP AILFLPRKHS KPELCANPEE GWVQNLMRRL DQPPAPGKQS 100
PGCRKNRGTS KSGKKGKGSK GCKRTEQTQP SRG 133
Length:133
Mass (Da):14,584
Last modified:January 11, 2011 - v1
Checksum:i7071750A2089A70B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131V → D in AAC17929. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U88322 mRNA. Translation: AAC17929.1.
AF171085 Genomic DNA. Translation: AAF16900.1.
AF307986 Genomic DNA. Translation: AAG45834.1.
AL824709 Genomic DNA. Translation: CAM22843.1.
CCDSiCCDS51145.1.
RefSeqiNP_001180595.1. NM_001193666.1.
NP_001180597.1. NM_001193668.1.
NP_001257289.1. NM_001270360.1.
NP_035465.2. NM_011335.2.
NP_075539.1. NM_023052.2.
XP_001473308.1. XM_001473258.4.
XP_001473444.1. XM_001473394.4.
UniGeneiMm.407493.

Genome annotation databases

EnsembliENSMUST00000098123; ENSMUSP00000095727; ENSMUSG00000073878.
ENSMUST00000098128; ENSMUSP00000095732; ENSMUSG00000094065.
ENSMUST00000177695; ENSMUSP00000136267; ENSMUSG00000094121.
ENSMUST00000178081; ENSMUSP00000137398; ENSMUSG00000096873.
ENSMUST00000178168; ENSMUSP00000136903; ENSMUSG00000096596.
ENSMUST00000178765; ENSMUSP00000137555; ENSMUSG00000096271.
ENSMUST00000178864; ENSMUSP00000137149; ENSMUSG00000095675.
GeneIDi100041504.
100041593.
100042493.
100504239.
100504346.
100862177.
65956.
KEGGimmu:100041504.
mmu:100041593.
mmu:100042493.
mmu:100504239.
mmu:100504346.
mmu:100862177.
mmu:65956.
UCSCiuc008skt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U88322 mRNA. Translation: AAC17929.1 .
AF171085 Genomic DNA. Translation: AAF16900.1 .
AF307986 Genomic DNA. Translation: AAG45834.1 .
AL824709 Genomic DNA. Translation: CAM22843.1 .
CCDSi CCDS51145.1.
RefSeqi NP_001180595.1. NM_001193666.1.
NP_001180597.1. NM_001193668.1.
NP_001257289.1. NM_001270360.1.
NP_035465.2. NM_011335.2.
NP_075539.1. NM_023052.2.
XP_001473308.1. XM_001473258.4.
XP_001473444.1. XM_001473394.4.
UniGenei Mm.407493.

3D structure databases

ProteinModelPortali P86792.
SMRi P86792. Positions 24-92.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P86792.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000098123 ; ENSMUSP00000095727 ; ENSMUSG00000073878 .
ENSMUST00000098128 ; ENSMUSP00000095732 ; ENSMUSG00000094065 .
ENSMUST00000177695 ; ENSMUSP00000136267 ; ENSMUSG00000094121 .
ENSMUST00000178081 ; ENSMUSP00000137398 ; ENSMUSG00000096873 .
ENSMUST00000178168 ; ENSMUSP00000136903 ; ENSMUSG00000096596 .
ENSMUST00000178765 ; ENSMUSP00000137555 ; ENSMUSG00000096271 .
ENSMUST00000178864 ; ENSMUSP00000137149 ; ENSMUSG00000095675 .
GeneIDi 100041504.
100041593.
100042493.
100504239.
100504346.
100862177.
65956.
KEGGi mmu:100041504.
mmu:100041593.
mmu:100042493.
mmu:100504239.
mmu:100504346.
mmu:100862177.
mmu:65956.
UCSCi uc008skt.1. mouse.

Organism-specific databases

CTDi 100042493.
65956.
MGIi MGI:1349182. Ccl21b.

Phylogenomic databases

HOGENOMi HOG000036685.
KOi K16062.
OrthoDBi EOG7GXPDG.
PhylomeDBi P86792.

Miscellaneous databases

NextBioi 320370.
PROi P86792.
SOURCEi Search...

Gene expression databases

Bgeei P86792.
Genevestigatori P84443.

Family and domain databases

InterProi IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension."
    Hromas R., Kim C.H., Klemsz M., Krathwohl M., Fife K., Cooper S., Schnizlein-Bick C., Broxmeyer H.E.
    J. Immunol. 159:2554-2558(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetus.
  2. "The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genes."
    Vassileva G., Soto H., Zlotnik A., Nakano H., Kakiuchi T., Hedrick J.A., Lira S.A.
    J. Exp. Med. 190:1183-1188(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
    Tissue: Embryonic stem cell.
  3. "Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation."
    Nakano H., Gunn M.D.
    J. Immunol. 166:361-369(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Ola.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes."
    Gunn M.D., Tangemann K., Tam C., Cyster J.G., Rosen S.D., Williams L.T.
    Proc. Natl. Acad. Sci. U.S.A. 95:258-263(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiCC21B_MOUSE
AccessioniPrimary (citable) accession number: P86792
Secondary accession number(s): O09002
, O09006, P84443, Q5M8M5, Q91V84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Three genes code for Ccl21 in mouse. Ccl21b and Ccl21c produce identical proteins while the protein produced by Ccl21a differs at only one position. Ccl21b and Ccl21c have Leu-65 (6Ckine-Leu) while Ccl21a has 'Ser-65' (6Ckine-Ser).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi