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Protein

Vacuolar fusion protein CCZ1 homolog

Gene

CCZ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar fusion protein CCZ1 homolog
Gene namesi
Name:CCZ1
Synonyms:C7orf28A
ORF Names:CGI-43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21691. CCZ1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi310943082.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 482481Vacuolar fusion protein CCZ1 homologPRO_0000401065Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei266 – 2661PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP86791.
MaxQBiP86791.
PaxDbiP86791.
PRIDEiP86791.

PTM databases

iPTMnetiP86791.
PhosphoSiteiP86791.

Expressioni

Gene expression databases

BgeeiP86791.
ExpressionAtlasiP86791. baseline and differential.
GenevisibleiP86791. HS.

Organism-specific databases

HPAiHPA045114.
HPA050006.

Interactioni

Protein-protein interaction databases

BioGridi119643. 10 interactions.
128773. 3 interactions.
MINTiMINT-3003231.
STRINGi9606.ENSP00000325681.

Structurei

3D structure databases

ProteinModelPortaliP86791.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CCZ1 family.Curated

Phylogenomic databases

eggNOGiKOG2622. Eukaryota.
ENOG410XRE1. LUCA.
GeneTreeiENSGT00390000004713.
InParanoidiP86791.
OrthoDBiEOG7J446N.
PhylomeDBiP86791.
TreeFamiTF314962.

Family and domain databases

InterProiIPR013176. DUF1712_fun.
[Graphical view]
PfamiPF08217. DUF1712. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P86791-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAAGAGS GPWAAQEKQF PPALLSFFIY NPRFGPREGQ EENKILFYHP
60 70 80 90 100
NEVEKNEKIR NVGLCEAIVQ FTRTFSPSKP AKSLHTQKNR QFFNEPEENF
110 120 130 140 150
WMVMVVRNPI IEKQSKDGKP VIEYQEEELL DKVYSSVLRQ CYSMYKLFNG
160 170 180 190 200
TFLKAMEDGG VKLLKERLEK FFHRYLQTLH LQSCDLLDIF GGISFFPLDK
210 220 230 240 250
MTYLKIQSFI NRMEESLNIV KYTAFLYNDQ LIWSGLEQDD MRILYKYLTT
260 270 280 290 300
SLFPRHIEPE LAGRDSPIRA EMPGNLQHYG RFLTGPLNLN DPDAKCRFPK
310 320 330 340 350
IFVNTDDTYE ELHLIVYKAM SAAVCFMIDA SVHPTLDFCR RLDSIVGPQL
360 370 380 390 400
TVLASDICEQ FNINKRMSGS EKEPQFKFIY FNHMNLAEKS TVHMRKTPSV
410 420 430 440 450
SLTSVHPDLM KILGDINSDF TRVDEDEEII VKAMSDYWVV GKKSDRRELY
460 470 480
VILNQKNANL IEVNEEVKKL CATQFNNIFF LD
Length:482
Mass (Da):55,866
Last modified:November 2, 2010 - v1
Checksum:iEE10E55EEC918C18
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 1511AAGAGSGPWAA → QRRPGPGAGLGG in AAD34038 (PubMed:10810093).CuratedAdd
BLAST
Sequence conflicti108 – 1081N → C in AAD34038 (PubMed:10810093).Curated
Sequence conflicti153 – 16210LKAMEDGGVK → PESHGRRRVQ in AAD34038 (PubMed:10810093).Curated
Sequence conflicti448 – 4492EL → DS in AAD34038 (PubMed:10810093).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151801 mRNA. Translation: AAD34038.1.
AK292326 mRNA. Translation: BAF85015.1.
AC004983 Genomic DNA. Translation: AAQ96868.1.
BC132749 mRNA. Translation: AAI32750.1.
BC132751 mRNA. Translation: AAI32752.1.
CCDSiCCDS34597.1.
PIRiT08806.
RefSeqiNP_056437.4. NM_015622.5.
NP_932765.1. NM_198097.3.
UniGeneiHs.530000.
Hs.567779.

Genome annotation databases

EnsembliENST00000325974; ENSP00000325681; ENSG00000122674.
GeneIDi221960.
51622.
KEGGihsa:221960.
hsa:51622.
UCSCiuc003spf.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151801 mRNA. Translation: AAD34038.1.
AK292326 mRNA. Translation: BAF85015.1.
AC004983 Genomic DNA. Translation: AAQ96868.1.
BC132749 mRNA. Translation: AAI32750.1.
BC132751 mRNA. Translation: AAI32752.1.
CCDSiCCDS34597.1.
PIRiT08806.
RefSeqiNP_056437.4. NM_015622.5.
NP_932765.1. NM_198097.3.
UniGeneiHs.530000.
Hs.567779.

3D structure databases

ProteinModelPortaliP86791.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119643. 10 interactions.
128773. 3 interactions.
MINTiMINT-3003231.
STRINGi9606.ENSP00000325681.

PTM databases

iPTMnetiP86791.
PhosphoSiteiP86791.

Polymorphism and mutation databases

DMDMi310943082.

Proteomic databases

EPDiP86791.
MaxQBiP86791.
PaxDbiP86791.
PRIDEiP86791.

Protocols and materials databases

DNASUi221960.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325974; ENSP00000325681; ENSG00000122674.
GeneIDi221960.
51622.
KEGGihsa:221960.
hsa:51622.
UCSCiuc003spf.4. human.

Organism-specific databases

CTDi221960.
51622.
GeneCardsiCCZ1.
H-InvDBHIX0006475.
HGNCiHGNC:21691. CCZ1.
HPAiHPA045114.
HPA050006.
neXtProtiNX_P86791.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2622. Eukaryota.
ENOG410XRE1. LUCA.
GeneTreeiENSGT00390000004713.
InParanoidiP86791.
OrthoDBiEOG7J446N.
PhylomeDBiP86791.
TreeFamiTF314962.

Miscellaneous databases

ChiTaRSiCCZ1. human.
PROiP86791.

Gene expression databases

BgeeiP86791.
ExpressionAtlasiP86791. baseline and differential.
GenevisibleiP86791. HS.

Family and domain databases

InterProiIPR013176. DUF1712_fun.
[Graphical view]
PfamiPF08217. DUF1712. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Placenta.
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCCZ1_HUMAN
AccessioniPrimary (citable) accession number: P86791
Secondary accession number(s): A2RU45
, O95766, Q9UG65, Q9Y359
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: November 2, 2010
Last modified: June 8, 2016
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.