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Protein

Vacuolar fusion protein CCZ1 homolog B

Gene

CCZ1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar fusion protein CCZ1 homolog B
Alternative name(s):
Vacuolar fusion protein CCZ1 homolog-like
Gene namesi
Name:CCZ1B
Synonyms:C7orf28B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21717. CCZ1B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiCCZ1B.
DMDMi310943081.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 482481Vacuolar fusion protein CCZ1 homolog BPRO_0000089584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei266 – 2661PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP86790.
PaxDbiP86790.
PRIDEiP86790.

PTM databases

iPTMnetiP86790.

Expressioni

Gene expression databases

BgeeiP86790.
ExpressionAtlasiP86790. baseline and differential.
GenevisibleiP86790. HS.

Organism-specific databases

HPAiHPA045114.
HPA050006.

Interactioni

Protein-protein interaction databases

BioGridi119643. 10 interactions.
128773. 3 interactions.
IntActiP86790. 1 interaction.
STRINGi9606.ENSP00000325681.

Structurei

3D structure databases

ProteinModelPortaliP86790.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CCZ1 family.Curated

Phylogenomic databases

eggNOGiKOG2622. Eukaryota.
ENOG410XRE1. LUCA.
InParanoidiP86790.
OrthoDBiEOG7J446N.
PhylomeDBiP86790.
TreeFamiTF314962.

Family and domain databases

InterProiIPR013176. DUF1712_fun.
[Graphical view]
PfamiPF08217. DUF1712. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P86790-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAAGAGS GPWAAQEKQF PPALLSFFIY NPRFGPREGQ EENKILFYHP
60 70 80 90 100
NEVEKNEKIR NVGLCEAIVQ FTRTFSPSKP AKSLHTQKNR QFFNEPEENF
110 120 130 140 150
WMVMVVRNPI IEKQSKDGKP VIEYQEEELL DKVYSSVLRQ CYSMYKLFNG
160 170 180 190 200
TFLKAMEDGG VKLLKERLEK FFHRYLQTLH LQSCDLLDIF GGISFFPLDK
210 220 230 240 250
MTYLKIQSFI NRMEESLNIV KYTAFLYNDQ LIWSGLEQDD MRILYKYLTT
260 270 280 290 300
SLFPRHIEPE LAGRDSPIRA EMPGNLQHYG RFLTGPLNLN DPDAKCRFPK
310 320 330 340 350
IFVNTDDTYE ELHLIVYKAM SAAVCFMIDA SVHPTLDFCR RLDSIVGPQL
360 370 380 390 400
TVLASDICEQ FNINKRMSGS EKEPQFKFIY FNHMNLAEKS TVHMRKTPSV
410 420 430 440 450
SLTSVHPDLM KILGDINSDF TRVDEDEEII VKAMSDYWVV GKKSDRRELY
460 470 480
VILNQKNANL IEVNEEVKKL CATQFNNIFF LD
Length:482
Mass (Da):55,866
Last modified:November 2, 2010 - v1
Checksum:iEE10E55EEC918C18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079882 Genomic DNA. Translation: AAQ93370.1.
BC010130 mRNA. Translation: AAH10130.1.
CCDSiCCDS5354.1.
PIRiT08806.
RefSeqiNP_056437.4. NM_015622.5.
NP_932765.1. NM_198097.3.
UniGeneiHs.530000.
Hs.567779.

Genome annotation databases

EnsembliENST00000316731; ENSP00000314544; ENSG00000146574.
GeneIDi221960.
51622.
KEGGihsa:221960.
hsa:51622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079882 Genomic DNA. Translation: AAQ93370.1.
BC010130 mRNA. Translation: AAH10130.1.
CCDSiCCDS5354.1.
PIRiT08806.
RefSeqiNP_056437.4. NM_015622.5.
NP_932765.1. NM_198097.3.
UniGeneiHs.530000.
Hs.567779.

3D structure databases

ProteinModelPortaliP86790.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119643. 10 interactions.
128773. 3 interactions.
IntActiP86790. 1 interaction.
STRINGi9606.ENSP00000325681.

PTM databases

iPTMnetiP86790.

Polymorphism and mutation databases

BioMutaiCCZ1B.
DMDMi310943081.

Proteomic databases

EPDiP86790.
PaxDbiP86790.
PRIDEiP86790.

Protocols and materials databases

DNASUi221960.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316731; ENSP00000314544; ENSG00000146574.
GeneIDi221960.
51622.
KEGGihsa:221960.
hsa:51622.

Organism-specific databases

CTDi221960.
51622.
GeneCardsiCCZ1B.
H-InvDBHIX0006458.
HGNCiHGNC:21717. CCZ1B.
HPAiHPA045114.
HPA050006.
neXtProtiNX_P86790.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2622. Eukaryota.
ENOG410XRE1. LUCA.
InParanoidiP86790.
OrthoDBiEOG7J446N.
PhylomeDBiP86790.
TreeFamiTF314962.

Miscellaneous databases

ChiTaRSiCCZ1B. human.
PROiP86790.

Gene expression databases

BgeeiP86790.
ExpressionAtlasiP86790. baseline and differential.
GenevisibleiP86790. HS.

Family and domain databases

InterProiIPR013176. DUF1712_fun.
[Graphical view]
PfamiPF08217. DUF1712. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Placenta.
  4. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCCZ1B_HUMAN
AccessioniPrimary (citable) accession number: P86790
Secondary accession number(s): A2RU45
, O95766, Q9UG65, Q9Y359
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: November 2, 2010
Last modified: June 8, 2016
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.