Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Parvalbumin beta 3

Gene
N/A
Organism
Merluccius australis australis (Austral hake)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity).By similarity

Miscellaneous

Is regarded as an important allergen.By similarity1 Publication
On the 2D-gel the determined pI of this protein is: 4.14, its MW is: 11.53 kDa.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi51Calcium 1By similarity1
Metal bindingi53Calcium 1By similarity1
Metal bindingi55Calcium 1By similarity1
Metal bindingi57Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi59Calcium 1By similarity1
Metal bindingi62Calcium 1By similarity1
Metal bindingi90Calcium 2By similarity1
Metal bindingi92Calcium 2By similarity1
Metal bindingi94Calcium 2By similarity1
Metal bindingi96Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi101Calcium 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi51 – 621PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi90 – 1012PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

Molecular functionMuscle protein
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin beta 31 Publication
OrganismiMerluccius australis australis (Austral hake)
Taxonomic identifieri307686 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiMerlucciidaeMerluccius

Pathology & Biotechi

Keywords - Diseasei

Allergen

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003994071 – 108Parvalbumin beta 3Add BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

PTM databases

iPTMnetiP86748.

Structurei

3D structure databases

SMRiP86748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 73EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini77 – 108EF-hand 2PROSITE-ProRule annotationAdd BLAST32

Sequence similaritiesi

Belongs to the parvalbumin family.Sequence analysis

Keywords - Domaini

Repeat

Family and domain databases

InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiView protein in Pfam
PF13499. EF-hand_7. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.

Sequencei

Sequence statusi: Complete.

P86748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AFSGILAEAD IAAALKACEA ADSFNYKAFF AKVGLSAKSA DDIKKAFFVI
60 70 80 90 100
DQDKSGFIEE DELKLFLQVF SAGARALTDA ETKAFLKAGD SDGDGAIGVD

EFAVLVKA
Length:108
Mass (Da):11,320
Last modified:October 5, 2010 - v1
Checksum:iDBA2AE6C2F5A01B6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence uncertaintyi5I or L1 Publication1
Sequence uncertaintyi6L or I1 Publication1
Sequence uncertaintyi11I or L1 Publication1
Sequence uncertaintyi15L or I1 Publication1
Sequence uncertaintyi16K or Q1 Publication1
Sequence uncertaintyi27K or Q1 Publication1
Sequence uncertaintyi32K or Q1 Publication1
Sequence uncertaintyi35L or I1 Publication1
Sequence uncertaintyi38K or Q1 Publication1
Sequence uncertaintyi43I or L1 Publication1
Sequence uncertaintyi44K or Q1 Publication1
Sequence uncertaintyi45K or Q1 Publication1
Sequence uncertaintyi50I or L1 Publication1
Sequence uncertaintyi52Q or K1 Publication1
Sequence uncertaintyi54K or Q1 Publication1
Sequence uncertaintyi58I or L1 Publication1
Sequence uncertaintyi63L or I1 Publication1
Sequence uncertaintyi64K or Q1 Publication1
Sequence uncertaintyi65L or I1 Publication1
Sequence uncertaintyi67L or I1 Publication1
Sequence uncertaintyi68Q or K1 Publication1
Sequence uncertaintyi77L or I1 Publication1
Sequence uncertaintyi83K or Q1 Publication1
Sequence uncertaintyi86L or I1 Publication1
Sequence uncertaintyi87K or Q1 Publication1
Sequence uncertaintyi97I or L1 Publication1
Sequence uncertaintyi105L or I1 Publication1
Sequence uncertaintyi107K or Q1 Publication1

Mass spectrometryi

Molecular mass is 11354.803±0.0133 Da from positions 1 - 108. Determined by ESI. 1 Publication

Similar proteinsi

Entry informationi

Entry nameiPRVB3_MERAA
AccessioniPrimary (citable) accession number: P86748
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 5, 2010
Last modified: October 25, 2017
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families