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P86687

- HUGA_POLPI

UniProt

P86687 - HUGA_POLPI

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Protein
Hyaluronidase
Gene
N/A
Organism
Polybia paulista (Neotropical social wasp) (Swarm-founding polistine wasp)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides By similarity.

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei66 – 661Proton donor By similarityBy similarity

GO - Molecular functioni

  1. hyalurononglucosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. defense response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase (EC:3.2.1.35)
Short name:
Hya
Alternative name(s):
Hyaluronoglucosaminidase
OrganismiPolybia paulista (Neotropical social wasp) (Swarm-founding polistine wasp)
Taxonomic identifieri291283 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaePolistinaeEpiponiniPolybia

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›288›288Hyaluronidase
PRO_0000396653Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 265 By similarityBy similarity
Glycosylationi36 – 361N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi142 ↔ 154 By similarityBy similarity
Glycosylationi282 – 2821N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR001329. Venom_Hyaluronidase.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PRINTSiPR00846. GLHYDRLASE56.
PR00847. HYALURONDASE.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Fragment.

P86687-1 [UniParc]FASTAAdd to Basket

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GETISIYYDP GKFPALMPLK NGNYEERNGG VPQRGNITIH LQQFNEDLDK    50
MTPDKNFGGI GVIDFERWKP IFRQNWGNTE IHKKYSIELV RYEHPKWSES 100
MIEAEATKKF EKYARLFMEE TLKLAKKTRK RAKWGYYGFP YCYNYTPNNP 150
GPDCDAKAMI ENDRLSWMYN NQEILFPSVY VRHELTPDQR VYLVQGRIKE 200
AVRISNNLKH SPKVLSYWWY VYQDKMDIFL SETDVKKTFQ EIVTNGGDGI 250
IIWGSSSDVN SLSKCKRLRE YLLNTLGPFA VNVTETVN 288
Length:288
Mass (Da):33,746
Last modified:August 10, 2010 - v1
Checksum:iABFF0679F329016F
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei288 – 2881

Cross-referencesi

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR001329. Venom_Hyaluronidase.
[Graphical view ]
PANTHERi PTHR11769. PTHR11769. 1 hit.
Pfami PF01630. Glyco_hydro_56. 1 hit.
[Graphical view ]
PRINTSi PR00846. GLHYDRLASE56.
PR00847. HYALURONDASE.
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of Hyaluronidase allergen from the venom of the social wasp Polybia paulista (Hymenoptera, Vespidae)."
    Pinto J.R.A.S.
    Thesis (2008), Sao Paulo State University, Brazil
    Cited for: PROTEIN SEQUENCE, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALLERGEN.
    Tissue: Venom.
  2. "Structural characterization of hyaluronidase isoforms from the venom of the social wasp Polybia paulista (Hymenoptera, Vespidae)."
    Pinto J.R.A.S., Santos L.D., Arcuri H.A., Dias N.B., Palma M.S.
    Submitted (JUN-2010) to UniProtKB
    Cited for: PROTEIN SEQUENCE.
    Tissue: Venom.

Entry informationi

Entry nameiHUGA_POLPI
AccessioniPrimary (citable) accession number: P86687
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: August 10, 2010
Last modified: December 11, 2013
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

On the 2D-gel the determined pI of this protein is: 9.5, its MW is: 44.1 kDa.1 Publication

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3