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P86687

- HUGA_POLPI

UniProt

P86687 - HUGA_POLPI

Protein

Hyaluronidase

Gene
N/A
Organism
Polybia paulista (Neotropical social wasp) (Swarm-founding polistine wasp)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 13 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides.By similarity

    Catalytic activityi

    Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei66 – 661Proton donorBy similarity

    GO - Molecular functioni

    1. hyalurononglucosaminidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. defense response Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hyaluronidase2 Publications (EC:3.2.1.35)
    Short name:
    HyaBy similarity
    Alternative name(s):
    HyaluronoglucosaminidaseBy similarity
    OrganismiPolybia paulista (Neotropical social wasp) (Swarm-founding polistine wasp)
    Taxonomic identifieri291283 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaePolistinaeEpiponiniPolybia

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.1 Publication

    Keywords - Diseasei

    Allergen

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›288›288HyaluronidasePRO_0000396653Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi? ↔ 265By similarity
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi142 ↔ 154By similarity
    Glycosylationi282 – 2821N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.1 Publication

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 56 family.Sequence Analysis

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR017853. Glycoside_hydrolase_SF.
    IPR018155. Hyaluronidase.
    IPR001329. Venom_Hyaluronidase.
    [Graphical view]
    PANTHERiPTHR11769. PTHR11769. 1 hit.
    PfamiPF01630. Glyco_hydro_56. 1 hit.
    [Graphical view]
    PRINTSiPR00846. GLHYDRLASE56.
    PR00847. HYALURONDASE.
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    P86687-1 [UniParc]FASTAAdd to Basket

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    GETISIYYDP GKFPALMPLK NGNYEERNGG VPQRGNITIH LQQFNEDLDK    50
    MTPDKNFGGI GVIDFERWKP IFRQNWGNTE IHKKYSIELV RYEHPKWSES 100
    MIEAEATKKF EKYARLFMEE TLKLAKKTRK RAKWGYYGFP YCYNYTPNNP 150
    GPDCDAKAMI ENDRLSWMYN NQEILFPSVY VRHELTPDQR VYLVQGRIKE 200
    AVRISNNLKH SPKVLSYWWY VYQDKMDIFL SETDVKKTFQ EIVTNGGDGI 250
    IIWGSSSDVN SLSKCKRLRE YLLNTLGPFA VNVTETVN 288
    Length:288
    Mass (Da):33,746
    Last modified:August 10, 2010 - v1
    Checksum:iABFF0679F329016F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Curated
    Non-terminal residuei288 – 2881Curated

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR017853. Glycoside_hydrolase_SF.
    IPR018155. Hyaluronidase.
    IPR001329. Venom_Hyaluronidase.
    [Graphical view ]
    PANTHERi PTHR11769. PTHR11769. 1 hit.
    Pfami PF01630. Glyco_hydro_56. 1 hit.
    [Graphical view ]
    PRINTSi PR00846. GLHYDRLASE56.
    PR00847. HYALURONDASE.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of Hyaluronidase allergen from the venom of the social wasp Polybia paulista (Hymenoptera, Vespidae)."
      Pinto J.R.A.S.
      Thesis (2008), Sao Paulo State University, Brazil
      Cited for: PROTEIN SEQUENCE, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALLERGEN.
      Tissue: Venom1 Publication.
    2. "Structural characterization of hyaluronidase isoforms from the venom of the social wasp Polybia paulista (Hymenoptera, Vespidae)."
      Pinto J.R.A.S., Santos L.D., Arcuri H.A., Dias N.B., Palma M.S.
      Submitted (JUN-2010) to UniProtKB
      Cited for: PROTEIN SEQUENCE.
      Tissue: Venom1 Publication.

    Entry informationi

    Entry nameiHUGA_POLPI
    AccessioniPrimary (citable) accession number: P86687
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Miscellaneous

    On the 2D-gel the determined pI of this protein is: 9.5, its MW is: 44.1 kDa.1 Publication

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3