Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P86682

- HETN_HAEDE

UniProt

P86682 - HETN_HAEDE

Protein

Hementerin

Gene
N/A
Organism
Haementeria depressa (Leech)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cleaves fibrinogen Aalpha (FGA), gamma (FGG) and Bbeta (FGB) chains. Degrades cross-linked fibrin. Has no amidolytic, plasminogenolytic or caseinolytic activity. Inhibits platelet aggregation induced by collagen (IC50=7.5ug/ml) and various other agonists, presumably via activation of a nitridergic pathway. Inhibition is accompanied by reduced ATP release from and surface expression of SELP and CD63 on platelets as well as increased intracellular levels of Ca2+, cGMP and nitric oxide synthase activity.2 Publications

    Cofactori

    Calcium.1 Publication

    Enzyme regulationi

    Fibrino(geno)lytic activity inhibited by EDTA but not by PMSF, E-64, 6-AHA and aprotinin.1 Publication

    GO - Molecular functioni

    1. metallopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. blood coagulation Source: UniProtKB-KW
    2. fibrinolysis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Biological processi

    Blood coagulation, Fibrinolysis, Hemostasis

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hementerin1 Publication (EC:3.4.-.-)
    OrganismiHaementeria depressa (Leech)
    Taxonomic identifieri279730 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataHirudinidaHirudineaRhynchobdellidaGlossiphoniidaeHaementeria

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›30›30HementerinPRO_0000397938Add
    BLAST

    Sequencei

    Sequence statusi: Fragments.

    P86682-1 [UniParc]FASTAAdd to Basket

    « Hide

    XTLSEPEPTC SIEYFRYQAI EDCEYSISVK                         30
    Length:30
    Mass (Da):3,513
    Last modified:October 5, 2010 - v1
    Checksum:i5A492FA070690DD1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-adjacent residuesi9 – 1021 Publication
    Non-adjacent residuesi16 – 1721 Publication
    Non-terminal residuei30 – 3011 Publication

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Fibrino(geno)lytic properties of purified hementerin, a metalloproteinase from the leech Haementeria depressa."
      Chudzinski-Tavassi A.M., Kelen E.M., de Paula Rosa A.P., Loyau S., Sampaio C.A., Bon C., Angles-Cano E.
      Thromb. Haemost. 80:155-160(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FUNCTION, COFACTOR, ENZYME REGULATION.
      Tissue: Salivary gland1 Publication.
    2. "Nitridergic platelet pathway activation by hementerin, a metalloprotease from the leech Haementeria depressa."
      Chudzinski-Tavassi A.M., Bermej E., Rosenstein R.E., Faria F., Sarmiento M.I., Alberto F., Sampaio M.U., Lazzari M.A.
      Biol. Chem. 384:1333-1339(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiHETN_HAEDE
    AccessioniPrimary (citable) accession number: P86682
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 7 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Caution

    The order of the peptides shown is unknown.1 Publication

    Keywords - Technical termi

    Direct protein sequencing

    External Data

    Dasty 3