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Protein

Osteocalcin

Gene

Bglap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Calcium 3By similarity
Metal bindingi66 – 661Calcium 2By similarity
Metal bindingi69 – 691Calcium 1By similarity
Metal bindingi69 – 691Calcium 2By similarity
Metal bindingi75 – 751Calcium 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biomineralization

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-159740. Gamma-carboxylation of protein precursors.
R-MMU-159763. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
R-MMU-159782. Removal of aminoterminal propeptides from gamma-carboxylated proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Osteocalcin
Alternative name(s):
Bone Gla protein
Short name:
BGP
Gamma-carboxyglutamic acid-containing protein
Gene namesi
Name:Bglap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:88156. Bglap.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular region Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323CuratedAdd
BLAST
Propeptidei24 – 4926CuratedPRO_0000011088Add
BLAST
Chaini50 – 9546OsteocalcinPRO_0000011089Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 6214-carboxyglutamatePROSITE-ProRule annotationBy similarity
Modified residuei66 – 6614-carboxyglutamatePROSITE-ProRule annotationBy similarity
Disulfide bondi68 ↔ 74PROSITE-ProRule annotation
Modified residuei69 – 6914-carboxyglutamatePROSITE-ProRule annotationBy similarity

Post-translational modificationi

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid

Proteomic databases

PaxDbiP86546.
PeptideAtlasiP86546.
PRIDEiP86546.

Expressioni

Tissue specificityi

Bone.

Gene expression databases

BgeeiENSMUSG00000074483.
GenevisibleiP86546. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075425.

Structurei

3D structure databases

ProteinModelPortaliP86546.
SMRiP86546. Positions 62-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 9247GlaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
GeneTreeiENSGT00410000026290.
HOGENOMiHOG000115820.
InParanoidiP86546.
OMAiWRAPFIS.
OrthoDBiEOG091G13UG.
PhylomeDBiP86546.
TreeFamiTF330920.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P86546-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTIFLLTLL TLAALCLSDL TDAKPSGPES DKAFMSKQEG NKVVNRLRRY
60 70 80 90
LGASVPSPDP LEPTREQCEL NPACDELSDQ YGLKTAYKRI YGITI
Length:95
Mass (Da):10,549
Last modified:July 13, 2010 - v1
Checksum:iADCE40516ECEF971
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24431 Genomic DNA. Translation: AAA39856.1.
U11542 mRNA. Translation: AAB40035.1.
AC102388 Genomic DNA. No translation available.
CCDSiCCDS17474.1.
RefSeqiNP_031567.1. NM_007541.3.
UniGeneiMm.389459.

Genome annotation databases

EnsembliENSMUST00000076048; ENSMUSP00000075425; ENSMUSG00000074483.
GeneIDi12096.
KEGGimmu:12096.
UCSCiuc008puy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24431 Genomic DNA. Translation: AAA39856.1.
U11542 mRNA. Translation: AAB40035.1.
AC102388 Genomic DNA. No translation available.
CCDSiCCDS17474.1.
RefSeqiNP_031567.1. NM_007541.3.
UniGeneiMm.389459.

3D structure databases

ProteinModelPortaliP86546.
SMRiP86546. Positions 62-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075425.

Proteomic databases

PaxDbiP86546.
PeptideAtlasiP86546.
PRIDEiP86546.

Protocols and materials databases

DNASUi12096.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076048; ENSMUSP00000075425; ENSMUSG00000074483.
GeneIDi12096.
KEGGimmu:12096.
UCSCiuc008puy.2. mouse.

Organism-specific databases

CTDi632.
MGIiMGI:88156. Bglap.

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
GeneTreeiENSGT00410000026290.
HOGENOMiHOG000115820.
InParanoidiP86546.
OMAiWRAPFIS.
OrthoDBiEOG091G13UG.
PhylomeDBiP86546.
TreeFamiTF330920.

Enzyme and pathway databases

ReactomeiR-MMU-159740. Gamma-carboxylation of protein precursors.
R-MMU-159763. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
R-MMU-159782. Removal of aminoterminal propeptides from gamma-carboxylated proteins.

Miscellaneous databases

PROiP86546.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074483.
GenevisibleiP86546. MM.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOSTCN_MOUSE
AccessioniPrimary (citable) accession number: P86546
Secondary accession number(s): P04641
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: September 7, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.