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Protein

Osteocalcin

Gene

Bglap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Calcium 3By similarity
Metal bindingi66 – 661Calcium 2By similarity
Metal bindingi69 – 691Calcium 1By similarity
Metal bindingi69 – 691Calcium 2By similarity
Metal bindingi75 – 751Calcium 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biomineralization

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-159740. Gamma-carboxylation of protein precursors.
R-MMU-159763. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
R-MMU-159782. Removal of aminoterminal propeptides from gamma-carboxylated proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Osteocalcin
Alternative name(s):
Bone Gla protein
Short name:
BGP
Gamma-carboxyglutamic acid-containing protein
Gene namesi
Name:Bglap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:88156. Bglap.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular region Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323CuratedAdd
BLAST
Propeptidei24 – 4926CuratedPRO_0000011088Add
BLAST
Chaini50 – 9546OsteocalcinPRO_0000011089Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 6214-carboxyglutamatePROSITE-ProRule annotationBy similarity
Modified residuei66 – 6614-carboxyglutamatePROSITE-ProRule annotationBy similarity
Disulfide bondi68 ↔ 74PROSITE-ProRule annotation
Modified residuei69 – 6914-carboxyglutamatePROSITE-ProRule annotationBy similarity

Post-translational modificationi

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid

Proteomic databases

PaxDbiP86546.
PeptideAtlasiP86546.
PRIDEiP86546.

Expressioni

Tissue specificityi

Bone.

Gene expression databases

BgeeiP86546.
GenevisibleiP86546. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075425.

Structurei

3D structure databases

ProteinModelPortaliP86546.
SMRiP86546. Positions 62-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 9247GlaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
GeneTreeiENSGT00410000026290.
HOGENOMiHOG000115820.
InParanoidiP86546.
OMAiWRAPFIS.
OrthoDBiEOG7VDXRQ.
PhylomeDBiP86546.
TreeFamiTF330920.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P86546-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTIFLLTLL TLAALCLSDL TDAKPSGPES DKAFMSKQEG NKVVNRLRRY
60 70 80 90
LGASVPSPDP LEPTREQCEL NPACDELSDQ YGLKTAYKRI YGITI
Length:95
Mass (Da):10,549
Last modified:July 13, 2010 - v1
Checksum:iADCE40516ECEF971
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24431 Genomic DNA. Translation: AAA39856.1.
U11542 mRNA. Translation: AAB40035.1.
AC102388 Genomic DNA. No translation available.
CCDSiCCDS17474.1.
RefSeqiNP_031567.1. NM_007541.3.
UniGeneiMm.389459.

Genome annotation databases

EnsembliENSMUST00000076048; ENSMUSP00000075425; ENSMUSG00000074483.
GeneIDi12096.
KEGGimmu:12096.
UCSCiuc008puy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24431 Genomic DNA. Translation: AAA39856.1.
U11542 mRNA. Translation: AAB40035.1.
AC102388 Genomic DNA. No translation available.
CCDSiCCDS17474.1.
RefSeqiNP_031567.1. NM_007541.3.
UniGeneiMm.389459.

3D structure databases

ProteinModelPortaliP86546.
SMRiP86546. Positions 62-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075425.

Proteomic databases

PaxDbiP86546.
PeptideAtlasiP86546.
PRIDEiP86546.

Protocols and materials databases

DNASUi12096.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076048; ENSMUSP00000075425; ENSMUSG00000074483.
GeneIDi12096.
KEGGimmu:12096.
UCSCiuc008puy.2. mouse.

Organism-specific databases

CTDi632.
MGIiMGI:88156. Bglap.

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
GeneTreeiENSGT00410000026290.
HOGENOMiHOG000115820.
InParanoidiP86546.
OMAiWRAPFIS.
OrthoDBiEOG7VDXRQ.
PhylomeDBiP86546.
TreeFamiTF330920.

Enzyme and pathway databases

ReactomeiR-MMU-159740. Gamma-carboxylation of protein precursors.
R-MMU-159763. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
R-MMU-159782. Removal of aminoterminal propeptides from gamma-carboxylated proteins.

Miscellaneous databases

PROiP86546.
SOURCEiSearch...

Gene expression databases

BgeeiP86546.
GenevisibleiP86546. MM.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression."
    Desbois C., Hogue D.A., Karsenty G.
    J. Biol. Chem. 269:1183-1190(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Mouse osteocalcin cDNA sequence."
    Yotov W.V., St Arnaud R.
    Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Calvaria.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiOSTCN_MOUSE
AccessioniPrimary (citable) accession number: P86546
Secondary accession number(s): P04641
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: July 6, 2016
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.