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Protein

Zinc finger BED domain-containing protein 6

Gene

ZBED6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3' and represses transcription of IGF2. May also regulate expression of other target genes containing this consensus binding site (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri130 – 18758BED-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri264 – 32158BED-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger BED domain-containing protein 61 Publication
Gene namesi
Name:ZBED61 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:33273. ZBED6.

Subcellular locationi

  • Nucleus By similarity
  • Nucleusnucleolus By similarity

  • Note: Located predominantly in the nucleolus but is also dispersed throughout the nucleus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165752811.

Polymorphism and mutation databases

BioMutaiZBED6.
DMDMi292495573.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 979979Zinc finger BED domain-containing protein 6PRO_0000392573Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei381 – 3811PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP86452.
MaxQBiP86452.
PaxDbiP86452.
PeptideAtlasiP86452.
PRIDEiP86452.

PTM databases

iPTMnetiP86452.
PhosphoSiteiP86452.

Expressioni

Gene expression databases

BgeeiENSG00000257315.
GenevisibleiP86452. HS.

Organism-specific databases

HPAiHPA068807.

Interactioni

Protein-protein interaction databases

BioGridi1147772. 4 interactions.
IntActiP86452. 4 interactions.
STRINGi9606.ENSP00000447879.

Structurei

3D structure databases

ProteinModelPortaliP86452.
SMRiP86452. Positions 130-186, 265-319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni866 – 94883HATC (Hobo-Ac-Tam3) domainAdd
BLAST

Sequence similaritiesi

Contains 2 BED-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri130 – 18758BED-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri264 – 32158BED-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IR9U. Eukaryota.
ENOG410YAJD. LUCA.
GeneTreeiENSGT00530000063354.
InParanoidiP86452.
OMAiKTSAVWN.
OrthoDBiEOG091G0B61.
PhylomeDBiP86452.
TreeFamiTF322818.

Family and domain databases

InterProiIPR008906. HATC_C_dom.
IPR012337. RNaseH-like_dom.
IPR003656. Znf_BED.
[Graphical view]
PfamiPF05699. Dimer_Tnp_hAT. 1 hit.
PF02892. zf-BED. 2 hits.
[Graphical view]
SMARTiSM00614. ZnF_BED. 2 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS50808. ZF_BED. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P86452-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVCTLSVPV SSLSPGRRCN TFSDSGILGC VPINSNTDEE DVVEEKMVAE
60 70 80 90 100
GVNKEAKQPA KKKRKKGLRI KGKRRRKKLI LAKKFSKDLG SGRPVADAPA
110 120 130 140 150
LLASNDPEQD EESLFESNIE KQIYLPSTRA KTSIVWHFFH VDPQYTWRAI
160 170 180 190 200
CNLCEKSVSR GKPGSHLGTS TLQRHLQARH SPHWTRANKF GVASGEEDFT
210 220 230 240 250
LDVSLSPSSG SNGSFEYIPT DPLDDNRMGK KHDKSASDAL RAERGRFLIK
260 270 280 290 300
SNIVKHALIP GTRAKTSAVW NFFYTDPQHI SRAVCNICKR SVSRGRPGSH
310 320 330 340 350
LGTSTLQRHL QATHPIHWAV ANKDSGAVAN GLDEAETERS DLLSDTLHGE
360 370 380 390 400
KSTGSQDLTA EDLSDSDSDE PMLEVENRSE SPIPVAEQGT LMRAQERETT
410 420 430 440 450
CCGNPVSSHI SQAIIQMIVE DMHPYNYFST PAFQRFMQIV APDYRLPSET
460 470 480 490 500
YFFTKAVPQL YDCVREKIFL TLENVQSQKI HLTVDIWTHD PSTDYFIVTV
510 520 530 540 550
HWVSLETASF LNNGRIPDFR KWAVLCVTGL AKDCLITNIL QELNDQIGLW
560 570 580 590 600
LSPNFLIPSF IVSDNSSNVV HAIKDGGFTH VPCFLHCLNM VIQDFFCEHK
610 620 630 640 650
SIENMLVAAR KTCHHFSHSV KARQILQEFQ NDHQLPWKNL KQDETGHWIS
660 670 680 690 700
TFYMLKWLLE HCYSVHHSLG RASGVVLTSL QWTLMTYVCD ILKPFEEATQ
710 720 730 740 750
KVSVKTAGLN QVLPLIHHLL LSLQKLREDF QVRGITQALN LVDSLSLKLE
760 770 780 790 800
TDTLLSAMLK SKPCILATLL DPCFKNSLED FFPQGADLET YKQFLAEEVC
810 820 830 840 850
NYMESSPEIC QIPTSEASCP SVTVGADSFT SSLKEGTSSS GSVDSSAVDN
860 870 880 890 900
VALGSKSFMF PSAVAVVDEY FKEKYSEFSG GDDPLIYWQR KISIWPALTQ
910 920 930 940 950
VAIQYLSCPM CSWQSECIFT KNSHFHPKQI MSLDFDNIEQ LMFLKMNLKN
960 970
VNYDYSTLVL SWDPEQNEVV QSSEKEILP
Length:979
Mass (Da):109,973
Last modified:March 23, 2010 - v1
Checksum:i48D5B5EE9AFDC2A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114402 Genomic DNA. No translation available.
CCDSiCCDS55673.1.
RefSeqiNP_001167579.1. NM_001174108.1.
UniGeneiHs.716666.

Genome annotation databases

EnsembliENST00000550078; ENSP00000447879; ENSG00000257315.
GeneIDi100381270.
KEGGihsa:100381270.
UCSCiuc021phs.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114402 Genomic DNA. No translation available.
CCDSiCCDS55673.1.
RefSeqiNP_001167579.1. NM_001174108.1.
UniGeneiHs.716666.

3D structure databases

ProteinModelPortaliP86452.
SMRiP86452. Positions 130-186, 265-319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1147772. 4 interactions.
IntActiP86452. 4 interactions.
STRINGi9606.ENSP00000447879.

PTM databases

iPTMnetiP86452.
PhosphoSiteiP86452.

Polymorphism and mutation databases

BioMutaiZBED6.
DMDMi292495573.

Proteomic databases

EPDiP86452.
MaxQBiP86452.
PaxDbiP86452.
PeptideAtlasiP86452.
PRIDEiP86452.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000550078; ENSP00000447879; ENSG00000257315.
GeneIDi100381270.
KEGGihsa:100381270.
UCSCiuc021phs.2. human.

Organism-specific databases

CTDi100381270.
GeneCardsiZBED6.
H-InvDBHIX0159983.
HGNCiHGNC:33273. ZBED6.
HPAiHPA068807.
MIMi613512. gene.
neXtProtiNX_P86452.
PharmGKBiPA165752811.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR9U. Eukaryota.
ENOG410YAJD. LUCA.
GeneTreeiENSGT00530000063354.
InParanoidiP86452.
OMAiKTSAVWN.
OrthoDBiEOG091G0B61.
PhylomeDBiP86452.
TreeFamiTF322818.

Miscellaneous databases

GeneWikiiZBED6.
PROiP86452.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000257315.
GenevisibleiP86452. HS.

Family and domain databases

InterProiIPR008906. HATC_C_dom.
IPR012337. RNaseH-like_dom.
IPR003656. Znf_BED.
[Graphical view]
PfamiPF05699. Dimer_Tnp_hAT. 1 hit.
PF02892. zf-BED. 2 hits.
[Graphical view]
SMARTiSM00614. ZnF_BED. 2 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS50808. ZF_BED. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBED6_HUMAN
AccessioniPrimary (citable) accession number: P86452
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: September 7, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by an exapted DNA transposon located in an intron of the ZC3H11A gene.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.