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Protein

Parvalbumin beta 2

Gene
N/A
Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi50Calcium 1By similarity1
Metal bindingi52Calcium 1By similarity1
Metal bindingi54Calcium 1By similarity1
Metal bindingi56Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi58Calcium 1By similarity1
Metal bindingi61Calcium 1By similarity1
Metal bindingi89Calcium 2By similarity1
Metal bindingi91Calcium 2By similarity1
Metal bindingi93Calcium 2By similarity1
Metal bindingi100Calcium 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi50 – 611PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi89 – 1002PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin beta 21 PublicationBy similarity
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

  • sarcoplasm Source: AgBase
Complete GO annotation...

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei8150. Onc m 1.
9515. Onc m 1.0201.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003914221 – 107Parvalbumin beta 2Add BLAST107

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

Structurei

3D structure databases

ProteinModelPortaliP86432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 72EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini76 – 107EF-hand 2PROSITE-ProRule annotationAdd BLAST32

Sequence similaritiesi

Belongs to the parvalbumin family.Sequence analysis
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P86432-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SFAGLNDADV AAALAACAAA DSFNHKAFFA KXXXXXXSPD DLKKXXXXLD
60 70 80 90 100
QDKSGFLEED ELKLFLQNFS ASARALTDAE TKXXXXAGDA DGDGMLGLDE

FAVLVKQ
Length:107
Mass (Da):11,345
Last modified:February 9, 2010 - v1
Checksum:i0B8BAA1331A2EC2F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence uncertaintyi5L or I1 Publication1
Sequence uncertaintyi14L or I1 Publication1
Sequence uncertaintyi42L or I1 Publication1
Sequence uncertaintyi49L or I1 Publication1
Sequence uncertaintyi57L or I1 Publication1
Sequence uncertaintyi62L or I1 Publication1
Sequence uncertaintyi64L or I1 Publication1
Sequence uncertaintyi66L or I1 Publication1
Sequence uncertaintyi76L or I1 Publication1
Sequence uncertaintyi96L or I1 Publication1
Sequence uncertaintyi98L or I1 Publication1
Sequence uncertaintyi104L or I1 Publication1

Mass spectrometryi

Molecular mass is 11232.5 Da from positions 1 - 107. Determined by MALDI. 1 Publication

Cross-referencesi

3D structure databases

ProteinModelPortaliP86432.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei8150. Onc m 1.
9515. Onc m 1.0201.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRVB2_ONCMY
AccessioniPrimary (citable) accession number: P86432
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 9, 2010
Last modified: January 20, 2016
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.