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Protein

Parvalbumin beta 1

Gene
N/A
Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi51Calcium 1By similarity1
Metal bindingi53Calcium 1By similarity1
Metal bindingi55Calcium 1By similarity1
Metal bindingi57Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi59Calcium 1By similarity1
Metal bindingi62Calcium 1By similarity1
Metal bindingi90Calcium 2By similarity1
Metal bindingi92Calcium 2By similarity1
Metal bindingi94Calcium 2By similarity1
Metal bindingi101Calcium 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi51 – 621PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi90 – 1012PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin beta 11 PublicationBy similarity
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

  • sarcoplasm Source: AgBase
Complete GO annotation...

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei8150. Onc m 1.
9514. Onc m 1.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003914211 – 108Parvalbumin beta 1Add BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP86431.

Structurei

3D structure databases

ProteinModelPortaliP86431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 73EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini77 – 108EF-hand 2PROSITE-ProRule annotationAdd BLAST32

Sequence similaritiesi

Belongs to the parvalbumin family.Sequence analysis
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P86431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ACAHLCKEAD LKTALEACKA ADSFNFKTFF HTLGFASKXX DDVKKXXXVL
60 70 80 90 100
DQDASGFLEV EELKLFLQNF CPKXXXLTDA ETKAFLKAGD ADGDGMLGLD

EFAVLVKQ
Length:108
Mass (Da):11,800
Last modified:February 9, 2010 - v1
Checksum:iEB4D4F5CFA36F34B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence uncertaintyi5L or I1 Publication1
Sequence uncertaintyi11L or I1 Publication1
Sequence uncertaintyi15L or I1 Publication1
Sequence uncertaintyi33L or I1 Publication1
Sequence uncertaintyi50L or I1 Publication1
Sequence uncertaintyi58L or I1 Publication1
Sequence uncertaintyi63L or I1 Publication1
Sequence uncertaintyi65L or I1 Publication1
Sequence uncertaintyi67L or I1 Publication1
Sequence uncertaintyi77L or I1 Publication1
Sequence uncertaintyi86L or I1 Publication1
Sequence uncertaintyi97L or I1 Publication1
Sequence uncertaintyi99L or I1 Publication1
Sequence uncertaintyi105L or I1 Publication1

Mass spectrometryi

Molecular mass is 11781 Da from positions 1 - 108. Determined by MALDI. 1 Publication

Cross-referencesi

3D structure databases

ProteinModelPortaliP86431.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei8150. Onc m 1.
9514. Onc m 1.0101.

Proteomic databases

PRIDEiP86431.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRVB1_ONCMY
AccessioniPrimary (citable) accession number: P86431
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 9, 2010
Last modified: November 30, 2016
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.