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Protein

Parvalbumin beta 1

Gene
N/A
Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi51 – 511Calcium 1By similarity
Metal bindingi53 – 531Calcium 1By similarity
Metal bindingi55 – 551Calcium 1By similarity
Metal bindingi57 – 571Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi59 – 591Calcium 1By similarity
Metal bindingi62 – 621Calcium 1By similarity
Metal bindingi90 – 901Calcium 2By similarity
Metal bindingi92 – 921Calcium 2By similarity
Metal bindingi94 – 941Calcium 2By similarity
Metal bindingi101 – 1011Calcium 2By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi51 – 62121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi90 – 101122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • calcium ion binding Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin beta 11 PublicationBy similarity
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

  • sarcoplasm Source: AgBase
Complete GO annotation...

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei8150. Onc m 1.
9514. Onc m 1.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 108108Parvalbumin beta 1PRO_0000391421Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Structurei

3D structure databases

ProteinModelPortaliP86431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 7336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini77 – 10832EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the parvalbumin family.Sequence analysis
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P86431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ACAHLCKEAD LKTALEACKA ADSFNFKTFF HTLGFASKXX DDVKKXXXVL
60 70 80 90 100
DQDASGFLEV EELKLFLQNF CPKXXXLTDA ETKAFLKAGD ADGDGMLGLD

EFAVLVKQ
Length:108
Mass (Da):11,800
Last modified:February 9, 2010 - v1
Checksum:iEB4D4F5CFA36F34B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence uncertaintyi5 – 51L or I1 Publication
Sequence uncertaintyi11 – 111L or I1 Publication
Sequence uncertaintyi15 – 151L or I1 Publication
Sequence uncertaintyi33 – 331L or I1 Publication
Sequence uncertaintyi50 – 501L or I1 Publication
Sequence uncertaintyi58 – 581L or I1 Publication
Sequence uncertaintyi63 – 631L or I1 Publication
Sequence uncertaintyi65 – 651L or I1 Publication
Sequence uncertaintyi67 – 671L or I1 Publication
Sequence uncertaintyi77 – 771L or I1 Publication
Sequence uncertaintyi86 – 861L or I1 Publication
Sequence uncertaintyi97 – 971L or I1 Publication
Sequence uncertaintyi99 – 991L or I1 Publication
Sequence uncertaintyi105 – 1051L or I1 Publication

Mass spectrometryi

Molecular mass is 11781 Da from positions 1 - 108. Determined by MALDI. 1 Publication

Cross-referencesi

3D structure databases

ProteinModelPortaliP86431.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei8150. Onc m 1.
9514. Onc m 1.0101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Detection of parvalbumins in fish protein extracts and fish containing products with scFv-antibodies."
    Kostadinova M., Bublin M., Radauer C., Briza P., Breiteneder H.
    Submitted (DEC-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, ALLERGEN, ACETYLATION AT ALA-1.
    Tissue: Muscle1 Publication.

Entry informationi

Entry nameiPRVB1_ONCMY
AccessioniPrimary (citable) accession number: P86431
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 9, 2010
Last modified: May 11, 2016
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.