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Protein

Hydroxyacyl-thioester dehydratase type 2, mitochondrial

Gene

HTD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis.1 Publication

Miscellaneous

This protein is produced by a bicistronic gene which also produces the RPP14 protein from an overlapping reading frame.1 Publication

Catalytic activityi

(3R)-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O.1 Publication
(3R)-hydroxyacyl-[acyl-carrier-protein] = trans-2-enoyl-[acyl-carrier-protein] + H2O.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processFatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-75105 Fatty acyl-CoA biosynthesis

Chemistry databases

SwissLipidsiSLP:000001096

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyacyl-thioester dehydratase type 2, mitochondrial1 Publication (EC:4.2.1.-)
Short name:
HsHTD21 Publication
Alternative name(s):
3-hydroxyacyl-[acyl-carrier-protein] dehydrataseBy similarity
Gene namesi
Name:HTD21 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000255154.7
HGNCiHGNC:53111 HTD2
neXtProtiNX_P86397

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi62D → A: Abolishes ability to complement a htd2-delta mutant yeast. 1 Publication1
Mutagenesisi67H → A: Abolishes ability to complement a htd2-delta mutant yeast. 1 Publication1

Organism-specific databases

DisGeNETi11102
OpenTargetsiENSG00000255154

Polymorphism and mutation databases

DMDMi281312149

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000390489? – 168Hydroxyacyl-thioester dehydratase type 2, mitochondrial1 Publication
Transit peptidei1 – ?Mitochondrion1 Publication

Proteomic databases

MaxQBiP86397
PaxDbiP86397
PeptideAtlasiP86397
PRIDEiP86397

Expressioni

Tissue specificityi

Highly expressed in heart and liver. Expressed at lower levels in skeletal muscle, spleen, kidney and placenta.1 Publication

Gene expression databases

BgeeiENSG00000255154
ExpressionAtlasiP86397 baseline and differential
GenevisibleiP86397 HS

Organism-specific databases

HPAiHPA066812

Interactioni

Protein-protein interaction databases

IntActiP86397, 1 interactor
STRINGi9606.ENSP00000437142

Structurei

Secondary structure

1168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi41 – 47Combined sources7
Helixi50 – 60Combined sources11
Helixi66 – 68Combined sources3
Helixi85 – 98Combined sources14
Beta strandi106 – 113Combined sources8
Beta strandi123 – 134Combined sources12
Beta strandi137 – 146Combined sources10
Turni147 – 149Combined sources3
Beta strandi152 – 161Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IR3X-ray1.99A/B23-168[»]
ProteinModelPortaliP86397
SMRiP86397
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP86397

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 146MaoC-likeAdd BLAST106

Sequence similaritiesi

Belongs to the HTD2 family.Sequence analysis

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1206 Eukaryota
COG2030 LUCA
GeneTreeiENSGT00530000065109
InParanoidiP86397
KOiK22540
OMAiPGPGCIY
OrthoDBiEOG091G0WL7
PhylomeDBiP86397

Family and domain databases

InterProiView protein in InterPro
IPR029069 HotDog_dom_sf
IPR002539 MaoC_dom
PfamiView protein in Pfam
PF01575 MaoC_dehydratas, 1 hit
SUPFAMiSSF54637 SSF54637, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P86397-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPLISSHHL WWGGLRRTVC LNLPVLTLQH FQHMHIKVGD RAELRRAFTQ
60 70 80 90 100
TDVATFSELT GDVNPLHLNE DFAKHTKFGN TIVHGVLING LISALLGTKM
110 120 130 140 150
PGPGCVFLSQ EISFPAPLYI GEVVLASAEV KKLKRFIAII AVSCSVIESK
160
KTVMEGWVKV MVPEASKS
Length:168
Mass (Da):18,559
Last modified:December 15, 2009 - v1
Checksum:i6AAB9445C17F4FD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC098479 mRNA No translation available.
RefSeqiNP_001335641.1, NM_001348712.1
NP_001335642.1, NM_001348713.1
NP_001335643.1, NM_001348714.1
NP_001335644.1, NM_001348715.1
UniGeneiHs.446320

Genome annotation databases

EnsembliENST00000461393; ENSP00000484277; ENSG00000255154
ENST00000477305; ENSP00000481593; ENSG00000255154
ENST00000481972; ENSP00000482940; ENSG00000255154
GeneIDi109703458
KEGGihsa:109703458
UCSCiuc010hni.4 human

Similar proteinsi

Entry informationi

Entry nameiHTD2_HUMAN
AccessioniPrimary (citable) accession number: P86397
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: December 15, 2009
Last modified: May 23, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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