P86383 (LYS_MERLU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Lysozyme EC=3.2.1.17 Alternative name(s): 1,4-beta-N-acetylmuramidase
Organism	Meretrix lusoria (Hard clam) (Common Orient clam)
Taxonomic identifier	74491 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Mollusca › Bivalvia › Heteroconchia › Veneroida › Veneroidea › Veneridae › Meretrix

Protein attributes

Sequence length	122 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has antibacterial activity By similarity. UniProtKB P83673
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. UniProtKB P83673
Subcellular location	Secreted By similarity UniProtKB P83673.
Sequence similarities	Belongs to the lysozyme type I family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Molecular function	Antibiotic Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological_process	cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 122

122

Lysozyme

PRO_0000389530

Natural variations

Natural variant

5

1

I → T in isozyme B. Ref.1

Secondary structure

1

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122

Helix Strand Turn

Details...

Beta strand

4 – 6

3

Helix

8 – 19

12

Beta strand

20 – 22

3

Beta strand

26 – 29

4

Beta strand

32 – 35

4

Turn

36 – 39

4

Helix

42 – 47

6

Beta strand

52 – 54

3

Helix

55 – 59

5

Helix

62 – 80

19

Helix

86 – 95

10

Helix

99 – 101

3

Helix

104 – 112

9

Sequences

	Sequence		Length	Mass (Da)
	P86383 [UniParc]. Last modified November 24, 2009. Version 1. Checksum: 92366099E8AD7881	FASTA	122	13,377
	10 20 30 40 50 60 FAGGIVSQRC LSCICKMESG CRNVGCKMDM GSLSCGYFQI KEAYWIDCGR PGSSWKSCAA 70 80 90 100 110 120 SSYCASLCVQ NYMKRYAKWA GCPLRCEGFA REHNGGPRGC KKGSTIGYWN RLQKISGCHG VQ

References

[1]	"The complete amino acid sequence of invertebrate lysozyme from common orient clam." Araki T., Kuwano Y. Submitted (OCT-2009) to UniProtKB Cited for: PROTEIN SEQUENCE (ISOZYMES A AND B).

Cross-references

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3AB6	X-ray	1.78	A	1-122	[»]
3AYQ	X-ray	1.77	A	1-122	[»]

ProteinModelPortal

P86383.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR008597. Destabilase.
IPR023346. Lysozyme-like_dom.
[Graphical view]

PANTHER

PTHR11195. PTHR11195. 1 hit.

Pfam

PF05497. Destabilase. 1 hit.
[Graphical view]

SUPFAM

SSF53955. SSF53955. 1 hit.

ProtoNet

Search...

Entry information

Entry name

LYS_MERLU

Accession

Primary (citable) accession number: P86383

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 24, 2009
Last sequence update:	November 24, 2009
Last modified:	October 3, 2012
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)