Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P86383

- LYS_MERLU

UniProt

P86383 - LYS_MERLU

Protein

Lysozyme

Gene
N/A
Organism
Meretrix lusoria (Hard clam) (Common Orient clam)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Has antibacterial activity.By similarity

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.By similarity

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. cytolysis Source: UniProtKB-KW
    2. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme1 Publication (EC:3.2.1.17)
    Alternative name(s):
    1,4-beta-N-acetylmuramidaseBy similarity
    OrganismiMeretrix lusoria (Hard clam) (Common Orient clam)
    Taxonomic identifieri74491 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaHeteroconchiaVeneroidaVeneroideaVeneridaeMeretrix

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 122122LysozymePRO_0000389530Add
    BLAST

    Structurei

    Secondary structure

    1
    122
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 63
    Helixi8 – 1912
    Beta strandi20 – 223
    Beta strandi26 – 294
    Beta strandi32 – 354
    Turni36 – 394
    Helixi42 – 476
    Beta strandi52 – 543
    Helixi55 – 595
    Helixi62 – 8019
    Helixi86 – 9510
    Helixi99 – 1013
    Helixi104 – 1129

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3AB6X-ray1.78A1-122[»]
    3AYQX-ray1.77A1-122[»]
    ProteinModelPortaliP86383.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the lysozyme type I family.Sequence Analysis

    Family and domain databases

    InterProiIPR008597. Destabilase.
    IPR023346. Lysozyme-like_dom.
    [Graphical view]
    PANTHERiPTHR11195. PTHR11195. 1 hit.
    PfamiPF05497. Destabilase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P86383-1 [UniParc]FASTAAdd to Basket

    « Hide

    FAGGIVSQRC LSCICKMESG CRNVGCKMDM GSLSCGYFQI KEAYWIDCGR    50
    PGSSWKSCAA SSYCASLCVQ NYMKRYAKWA GCPLRCEGFA REHNGGPRGC 100
    KKGSTIGYWN RLQKISGCHG VQ 122
    Length:122
    Mass (Da):13,377
    Last modified:November 24, 2009 - v1
    Checksum:i92366099E8AD7881
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51I → T in isozyme B. 1 Publication

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3AB6 X-ray 1.78 A 1-122 [» ]
    3AYQ X-ray 1.77 A 1-122 [» ]
    ProteinModelPortali P86383.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR008597. Destabilase.
    IPR023346. Lysozyme-like_dom.
    [Graphical view ]
    PANTHERi PTHR11195. PTHR11195. 1 hit.
    Pfami PF05497. Destabilase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete amino acid sequence of invertebrate lysozyme from common orient clam."
      Araki T., Kuwano Y.
      Submitted (OCT-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE (ISOZYMES A AND B).

    Entry informationi

    Entry nameiLYS_MERLU
    AccessioniPrimary (citable) accession number: P86383
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 24, 2009
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 12 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3