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Protein

Alpha-conotoxin-like ts14a

Gene
N/A
Organism
Conus tessulatus (Tessellate cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.By similarity

GO - Molecular functioni

  • acetylcholine receptor inhibitor activity Source: UniProtKB
  • toxin activity Source: UniProtKB-KW

GO - Biological processi

  • pathogenesis Source: UniProtKB

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin-like ts14a1 Publication
OrganismiConus tessulatus (Tessellate cone)
Taxonomic identifieri101317 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00004058021 – 20Alpha-conotoxin-like ts14a1 PublicationAdd BLAST20

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 161 Publication
Disulfide bondi14 ↔ 201 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Family & Domainsi

Domaini

The cysteine framework is XIV (C-C-C-C).Curated

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Sequence analysis

Sequencei

Sequence statusi: Complete.

P86362-1 [UniParc]FASTAAdd to basket

« Hide

        10         20
DGCPPHPVPG MHPCMCTNTC
Length:20
Mass (Da):2,097
Last modified:March 8, 2011 - v1
Checksum:i458908B21DBDD58A
GO

Mass spectrometryi

Molecular mass is 2091.76 Da from positions 1 - 20. Determined by MALDI. 1 Publication

Entry informationi

Entry nameiCANA_CONTS
AccessioniPrimary (citable) accession number: P86362
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 22, 2017
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families