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Protein

Hyaluronidase-Pk1a

Gene
N/A
Organism
Phoneutria keyserlingi (Brazilian wandering spider) (Ctenus keyserlingii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides.By similarity

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase-Pk1aBy similarity (EC:3.2.1.35)
Short name:
Hya1 Publication
Alternative name(s):
HyaluronoglucosaminidaseBy similarity
OrganismiPhoneutria keyserlingi (Brazilian wandering spider) (Ctenus keyserlingii)
Taxonomic identifieri272754 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeLycosoideaCtenidaePhoneutria

Organism-specific databases

ArachnoServeriAS001206. Hyaluronidase-Pk1a (fragment).

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›32›32Hyaluronidase-Pk1aPRO_0000376024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi12 ↔ ?By similarity
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 56 family.Sequence analysis

Family and domain databases

InterProiIPR018155. Hyaluronidase.
[Graphical view]
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P86274-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
FEVYWNVPTL QCRAVYKMIF KLNRTYGIQX NA
Length:32
Mass (Da):3,879
Last modified:May 26, 2009 - v1
Checksum:i6CC71A1D7F06AB76
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei32 – 3211 Publication

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ArachnoServeriAS001206. Hyaluronidase-Pk1a (fragment).

Family and domain databases

InterProiIPR018155. Hyaluronidase.
[Graphical view]
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHYAL_PHOKE
AccessioniPrimary (citable) accession number: P86274
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: December 9, 2015
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

On the 2D-gel the MW of this protein is: 37 kDa.1 Publication

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.