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P86274 (HUGA_PHOKE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 8. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hyaluronidase

Short name=Hya
EC=3.2.1.35
Alternative name(s):
Hyaluronoglucosaminidase
OrganismPhoneutria keyserlingi (Brazilian wandering spider) (Ctenus keyserlingii)
Taxonomic identifier272754 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeLycosoideaCtenidaePhoneutria

Protein attributes

Sequence length32 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides By similarity.

Catalytic activity

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. Ref.1

Subcellular location

Secreted Ref.1.

Tissue specificity

Expressed by the venom gland. Ref.1

Miscellaneous

On the 2D-gel the MW of this protein is: 37 kDa. Ref.1

Sequence similarities

Belongs to the glycosyl hydrolase 56 family.

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhyalurononglucosaminidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›32›32Hyaluronidase
PRO_0000376024

Amino acid modifications

Glycosylation231N-linked (GlcNAc...) Potential
Disulfide bond12 ↔ ? By similarity UniProtKB Q08169

Experimental info

Non-terminal residue321

Sequences

Sequence LengthMass (Da)Tools
P86274 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 6CC71A1D7F06AB76

FASTA323,879
        10         20         30 
FEVYWNVPTL QCRAVYKMIF KLNRTYGIQX NA 

« Hide

References

[1]"Hyaluronidase enzyme in venom of spider P.keyserlinigi (wandering)."
Richardson M., Borges M.H., Souza I.A., Cordeiro M.N.
Submitted (APR-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Venom.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ArachnoServerAS001206. Hyaluronidase-Pk1a (fragment).

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameHUGA_PHOKE
AccessionPrimary (citable) accession number: P86274
Entry history
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: October 16, 2013
This is version 8 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries