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P86274

- HUGA_PHOKE

UniProt

P86274 - HUGA_PHOKE

Protein

Hyaluronidase

Gene
N/A
Organism
Phoneutria keyserlingi (Brazilian wandering spider) (Ctenus keyserlingii)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides.By similarity

    Catalytic activityi

    Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.1 Publication

    GO - Molecular functioni

    1. hyalurononglucosaminidase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HyaluronidaseBy similarity (EC:3.2.1.35)
    Short name:
    Hya1 Publication
    Alternative name(s):
    HyaluronoglucosaminidaseBy similarity
    OrganismiPhoneutria keyserlingi (Brazilian wandering spider) (Ctenus keyserlingii)
    Taxonomic identifieri272754 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeLycosoideaCtenidaePhoneutria

    Organism-specific databases

    ArachnoServeriAS001206. Hyaluronidase-Pk1a (fragment).

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›32›32HyaluronidasePRO_0000376024Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi12 ↔ ?By similarity
    Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.1 Publication

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 56 family.Sequence Analysis

    Sequencei

    Sequence statusi: Fragment.

    P86274-1 [UniParc]FASTAAdd to Basket

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    FEVYWNVPTL QCRAVYKMIF KLNRTYGIQX NA                      32
    Length:32
    Mass (Da):3,879
    Last modified:May 26, 2009 - v1
    Checksum:i6CC71A1D7F06AB76
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei32 – 3211 Publication

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    ArachnoServeri AS001206. Hyaluronidase-Pk1a (fragment).

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Hyaluronidase enzyme in venom of spider P.keyserlinigi (wandering)."
      Richardson M., Borges M.H., Souza I.A., Cordeiro M.N.
      Submitted (APR-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Venom1 Publication.

    Entry informationi

    Entry nameiHUGA_PHOKE
    AccessioniPrimary (citable) accession number: P86274
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 9 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Miscellaneous

    On the 2D-gel the MW of this protein is: 37 kDa.1 Publication

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3