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Protein

Hyaluronidase-Pk1a

Gene
N/A
Organism
Phoneutria keyserlingi (Brazilian wandering spider) (Ctenus keyserlingii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides.By similarity

Miscellaneous

On the 2D-gel the MW of this protein is: 37 kDa.1 Publication

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase-Pk1aBy similarity (EC:3.2.1.35)
Short name:
Hya1 Publication
Alternative name(s):
HyaluronoglucosaminidaseBy similarity
OrganismiPhoneutria keyserlingi (Brazilian wandering spider) (Ctenus keyserlingii)
Taxonomic identifieri272754 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeLycosoideaCtenidaePhoneutria

Organism-specific databases

ArachnoServeriAS001206. Hyaluronidase-Pk1a (fragment).

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003760241 – ›32Hyaluronidase-Pk1aAdd BLAST›32

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi12 ↔ ?By similarity
Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 56 family.Sequence analysis

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR018155. Hyaluronidase.
PfamiView protein in Pfam
PF01630. Glyco_hydro_56. 1 hit.

Sequencei

Sequence statusi: Fragment.

P86274-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
FEVYWNVPTL QCRAVYKMIF KLNRTYGIQX NA
Length:32
Mass (Da):3,879
Last modified:May 26, 2009 - v1
Checksum:i6CC71A1D7F06AB76
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei321 Publication1

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHYAL_PHOKE
AccessioniPrimary (citable) accession number: P86274
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: May 10, 2017
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families