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P86274

- HUGA_PHOKE

UniProt

P86274 - HUGA_PHOKE

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Protein

Hyaluronidase

Gene
N/A
Organism
Phoneutria keyserlingi (Brazilian wandering spider) (Ctenus keyserlingii)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides.By similarity

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.1 Publication

GO - Molecular functioni

  1. hyalurononglucosaminidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
HyaluronidaseBy similarity (EC:3.2.1.35)
Short name:
Hya1 Publication
Alternative name(s):
HyaluronoglucosaminidaseBy similarity
OrganismiPhoneutria keyserlingi (Brazilian wandering spider) (Ctenus keyserlingii)
Taxonomic identifieri272754 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeLycosoideaCtenidaePhoneutria

Organism-specific databases

ArachnoServeriAS001206. Hyaluronidase-Pk1a (fragment).

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›32›32HyaluronidasePRO_0000376024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi12 ↔ ?By similarity
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 56 family.Sequence Analysis

Sequencei

Sequence statusi: Fragment.

P86274-1 [UniParc]FASTAAdd to Basket

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        10         20         30
FEVYWNVPTL QCRAVYKMIF KLNRTYGIQX NA
Length:32
Mass (Da):3,879
Last modified:May 26, 2009 - v1
Checksum:i6CC71A1D7F06AB76
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei32 – 3211 Publication

Cross-referencesi

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ArachnoServeri AS001206. Hyaluronidase-Pk1a (fragment).

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Hyaluronidase enzyme in venom of spider P.keyserlinigi (wandering)."
    Richardson M., Borges M.H., Souza I.A., Cordeiro M.N.
    Submitted (APR-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Venom1 Publication.

Entry informationi

Entry nameiHUGA_PHOKE
AccessioniPrimary (citable) accession number: P86274
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

On the 2D-gel the MW of this protein is: 37 kDa.1 Publication

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3