Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P86270 (KA211_TITSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 21.1
Alternative name(s):
Tityustoxin-15
Short name=Ts15
OrganismTityus serrulatus (Brazilian scorpion)
Taxonomic identifier6887 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Protein attributes

Sequence length36 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Reversibly and voltage-independently blocks voltage-gated potassium channels rKv1.2/KCNA2 (73%) (IC50=196 nM), hKv1.3/KCNA3 (50%) (IC50=508 nM), Shaker IR (30%), rKv1.6/KCNA6 (22%) (at 0.5 µM). Interaction of Ts15 with Kv1.3/KCNA3 is stronger than its interaction with Kv1.2/KCNA2. Ref.1

Subcellular location

Secreted Ref.1 Ref.1.

Tissue specificity

Expressed by the venom gland. Ref.1 Ref.1

Miscellaneous

Does not block voltage-gated sodium channels rNav1.4/SCN4A, hNav1.5/SCN5A, mNav1.6/SCN8A and rNav1.8/SCN10A, and Kv1.1/KCNA1, rKv1.4/KCNA4, rKv1.5/KCNA5, rKv2.1/KCNB1, hKv3.1/KCNC1, rKv4.2/KCND2, rKv4.3/KCND3 and hERG potassium channels, when tested at a concentration of 0.5 µM (Ref.1).

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 21 subfamily.

Mass spectrometry

Molecular mass is 3956 Da from positions 1 - 36. Determined by ESI. Ref.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3636Potassium channel toxin alpha-KTx 21.1 Ref.1
PRO_0000376048

Amino acid modifications

Disulfide bond6 ↔ 26 By similarity UniProtKB Q8I0L5
Disulfide bond11 ↔ 31 By similarity UniProtKB Q8I0L5
Disulfide bond15 ↔ 33 By similarity UniProtKB Q8I0L5

Sequences

Sequence LengthMass (Da)Tools
P86270 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 7DE0232A5D53CBAE

FASTA363,962
        10         20         30 
GKFGKCKPNI CAKTCQTEKG KGMGYCNKTE CVCSEW 

« Hide

References

[1]"Purification and characterization of Ts15, the first member of a new alpha-KTX subfamily from the venom of the Brazilian scorpion Tityus serrulatus."
Cologna C.T., Peigneur S., Rosa J.C., Selistre-de-Araujo H.S., Varanda W.A., Tytgat J., Arantes E.C.
Toxicon 58:54-61(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY.
Tissue: Venom.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameKA211_TITSE
AccessionPrimary (citable) accession number: P86270
Entry history
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: February 19, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries