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P86270

- KA211_TITSE

UniProt

P86270 - KA211_TITSE

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Protein
Potassium channel toxin alpha-KTx 21.1
Gene
N/A
Organism
Tityus serrulatus (Brazilian scorpion)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Reversibly and voltage-independently blocks voltage-gated potassium channels rKv1.2/KCNA2 (73%) (IC50=196 nM), hKv1.3/KCNA3 (50%) (IC50=508 nM), Shaker IR (30%), rKv1.6/KCNA6 (22%) (at 0.5 µM). Interaction of Ts15 with Kv1.3/KCNA3 is stronger than its interaction with Kv1.2/KCNA2.1 Publication

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 21.1
Alternative name(s):
Tityustoxin-15
Short name:
Ts15
OrganismiTityus serrulatus (Brazilian scorpion)
Taxonomic identifieri6887 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Subcellular locationi

Secreted 2 Publications

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3636Potassium channel toxin alpha-KTx 21.11 Publication
PRO_0000376048Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi6 ↔ 26 By similarityBy similarity
Disulfide bondi11 ↔ 31 By similarityBy similarity
Disulfide bondi15 ↔ 33 By similarityBy similarity
Glycosylationi27 – 271N-linked (GlcNAc...)

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom gland.2 Publications

Family & Domainsi

Sequence similaritiesi

Sequencei

Sequence statusi: Complete.

P86270-1 [UniParc]FASTAAdd to Basket

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GKFGKCKPNI CAKTCQTEKG KGMGYCNKTE CVCSEW                  36
Length:36
Mass (Da):3,962
Last modified:May 26, 2009 - v1
Checksum:i7DE0232A5D53CBAE
GO

Mass spectrometryi

Molecular mass is 3956 Da from positions 1 - 36. Determined by ESI. 1 Publication

Cross-referencesi

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Purification and characterization of Ts15, the first member of a new alpha-KTX subfamily from the venom of the Brazilian scorpion Tityus serrulatus."
    Cologna C.T., Peigneur S., Rosa J.C., Selistre-de-Araujo H.S., Varanda W.A., Tytgat J., Arantes E.C.
    Toxicon 58:54-61(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY.
    Tissue: Venom.
  2. "Moving pieces in a venomic puzzle: unveiling post-translationally modified toxins from Tityus serrulatus."
    Verano-Braga T., Dutra A.A., Leon I.R., Melo-Braga M.N., Roepstorff P., Pimenta A.M., Kjeldsen F.
    J. Proteome Res. 12:3460-3470(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-36, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Venom.

Entry informationi

Entry nameiKA211_TITSE
AccessioniPrimary (citable) accession number: P86270
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

Does not block voltage-gated sodium channels rNav1.4/SCN4A, hNav1.5/SCN5A, mNav1.6/SCN8A and rNav1.8/SCN10A, and Kv1.1/KCNA1, rKv1.4/KCNA4, rKv1.5/KCNA5, rKv2.1/KCNB1, hKv3.1/KCNC1, rKv4.2/KCND2, rKv4.3/KCND3 and hERG potassium channels, when tested at a concentration of 0.5 µM (1 Publication).

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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