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P86270

- KA211_TITSE

UniProt

P86270 - KA211_TITSE

Protein

Potassium channel toxin alpha-KTx 21.1

Gene
N/A
Organism
Tityus serrulatus (Brazilian scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Reversibly and voltage-independently blocks voltage-gated potassium channels rKv1.2/KCNA2 (73%) (IC50=196 nM), hKv1.3/KCNA3 (50%) (IC50=508 nM), Shaker IR (30%), rKv1.6/KCNA6 (22%) (at 0.5 µM). Interaction of Ts15 with Kv1.3/KCNA3 is stronger than its interaction with Kv1.2/KCNA2.1 Publication

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin alpha-KTx 21.1
    Alternative name(s):
    Tityustoxin-15
    Short name:
    Ts15
    OrganismiTityus serrulatus (Brazilian scorpion)
    Taxonomic identifieri6887 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 3636Potassium channel toxin alpha-KTx 21.1PRO_0000376048Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi6 ↔ 26By similarity
    Disulfide bondi11 ↔ 31By similarity
    Disulfide bondi15 ↔ 33By similarity
    Glycosylationi27 – 271N-linked (GlcNAc...)

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.1 Publication

    Family & Domainsi

    Sequence similaritiesi

    Sequencei

    Sequence statusi: Complete.

    P86270-1 [UniParc]FASTAAdd to Basket

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    GKFGKCKPNI CAKTCQTEKG KGMGYCNKTE CVCSEW                  36
    Length:36
    Mass (Da):3,962
    Last modified:May 26, 2009 - v1
    Checksum:i7DE0232A5D53CBAE
    GO

    Mass spectrometryi

    Molecular mass is 3956 Da from positions 1 - 36. Determined by ESI. 1 Publication

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Purification and characterization of Ts15, the first member of a new alpha-KTX subfamily from the venom of the Brazilian scorpion Tityus serrulatus."
      Cologna C.T., Peigneur S., Rosa J.C., Selistre-de-Araujo H.S., Varanda W.A., Tytgat J., Arantes E.C.
      Toxicon 58:54-61(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY.
      Tissue: Venom.
    2. "Moving pieces in a venomic puzzle: unveiling post-translationally modified toxins from Tityus serrulatus."
      Verano-Braga T., Dutra A.A., Leon I.R., Melo-Braga M.N., Roepstorff P., Pimenta A.M., Kjeldsen F.
      J. Proteome Res. 12:3460-3470(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-36, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Venom.

    Entry informationi

    Entry nameiKA211_TITSE
    AccessioniPrimary (citable) accession number: P86270
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Miscellaneous

    Does not block voltage-gated sodium channels rNav1.4/SCN4A, hNav1.5/SCN5A, mNav1.6/SCN8A and rNav1.8/SCN10A, and Kv1.1/KCNA1, rKv1.4/KCNA4, rKv1.5/KCNA5, rKv2.1/KCNB1, hKv3.1/KCNC1, rKv4.2/KCND2, rKv4.3/KCND3 and hERG potassium channels, when tested at a concentration of 0.5 µM.1 Publication

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3