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Protein

Purotoxin-1

Gene
N/A
Organism
Geolycosa sp. (strain A267TDLS2-KZARNA) (Wolf spider) (Lycosa kazakhstanicus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits P2RX3 receptors. Has an analgesic effect in rat. Enhances the high-affinity desensitization of P2X3 receptors. At 50 nM, decreases the IC50 for ambient ATP from 46.5 nM to 12.7 nM in mouse P2X3. Does not affect mouse P2X2 or P2X2/P2X3 receptors.2 Publications

GO - Molecular functioni

  • calcium channel inhibitor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCalcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Purotoxin-11 Publication
Short name:
PT11 Publication
OrganismiGeolycosa sp. (strain A267TDLS2-KZARNA) (Wolf spider) (Lycosa kazakhstanicus)
Taxonomic identifieri420151 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeLycosoideaLycosidaeGeolycosa

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00003954271 – 35Purotoxin-11 PublicationAdd BLAST35

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 161 Publication
Disulfide bondi10 ↔ 211 Publication
Disulfide bondi15 ↔ 321 Publication
Disulfide bondi23 ↔ 301 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

Secondary structure

135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 13Combined sources3
Beta strandi20 – 22Combined sources3
Beta strandi25 – 27Combined sources3
Beta strandi31 – 33Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KGUNMR-A1-35[»]
SMRiP86269.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP86269.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Keywords - Domaini

Knottin

Family and domain databases

CDDicd12960. Spider_toxin. 1 hit.
InterProiView protein in InterPro
IPR004169. Spidertoxin.

Sequencei

Sequence statusi: Complete.

P86269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
GYCAEKGIRC DDIHCCTGLK CKCNASGYNC VCRKK
Length:35
Mass (Da):3,845
Last modified:July 13, 2010 - v1
Checksum:iC861E5E17FB26D4B
GO

Similar proteinsi

Entry informationi

Entry nameiTXPR1_GEOA2
AccessioniPrimary (citable) accession number: P86269
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 30, 2016
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references