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P86250

- NDUS2_MESAU

UniProt

P86250 - NDUS2_MESAU

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Protein
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
Gene
NDUFS2
Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.By similarity

Cofactori

Binds 1 4Fe-4S cluster By similarity.By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. NAD binding Source: InterPro
  3. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  4. metal ion binding Source: UniProtKB-KW
  5. quinone binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    Complex I-49kD
    Short name:
    CI-49kD
    NADH-ubiquinone oxidoreductase 49 kDa subunit
    Gene namesi
    Name:NDUFS2
    OrganismiMesocricetus auratus (Golden hamster)
    Taxonomic identifieri10036 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

    Subcellular locationi

    Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 138›138NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
    PRO_0000394421Add
    BLAST

    Proteomic databases

    PRIDEiP86250.

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits. Component of the iron-sulfur (IP) fragment of the enzyme. Interacts with NDUFAF3 By similarity.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR001135. NADH_Q_OxRdtase_suD.
    IPR029014. NiFe_Hase-like.
    [Graphical view]
    PfamiPF00346. Complex1_49kDa. 2 hits.
    [Graphical view]
    SUPFAMiSSF56762. SSF56762. 1 hit.

    Sequencei

    Sequence statusi: Fragments.

    P86250-1 [UniParc]FASTAAdd to Basket

    « Hide

    TYLQALPYFD RLLNIQPPPR EKMFEFYERM HAAYIRPGGV HQDLPLGLMD    50
    DIYEFSKNFS LRIDEVEEML TNNRKTQPYD VYDQVEFDVP IGSRLYTEGY 100
    QVPPGATYTA IEAPKGHMLA DVVAIIGTQD IVFGEIDR 138
    Length:138
    Mass (Da):15,937
    Last modified:June 15, 2010 - v1
    Checksum:i19CF54EF543A6495
    GO

    Non-adjacent residues

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-adjacent residuesi11 – 122
    Non-adjacent residuesi20 – 212
    Non-adjacent residuesi29 – 302
    Non-adjacent residuesi74 – 752
    Non-adjacent residuesi94 – 952
    Non-adjacent residuesi115 – 1162

    Non-terminal residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Cross-referencesi

    3D structure databases

    ModBasei Search...

    Proteomic databases

    PRIDEi P86250.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR001135. NADH_Q_OxRdtase_suD.
    IPR029014. NiFe_Hase-like.
    [Graphical view ]
    Pfami PF00346. Complex1_49kDa. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56762. SSF56762. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa."
      Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.
      Asian J. Androl. 12:344-355(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiNDUS2_MESAU
    AccessioniPrimary (citable) accession number: P86250
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: June 11, 2014
    This is version 11 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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