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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

Gene

NDUFS2

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.By similarity

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialBy similarity (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-49kDBy similarity
Short name:
CI-49kDBy similarity
NADH-ubiquinone oxidoreductase 49 kDa subunitBy similarity
Gene namesi
Name:NDUFS2By similarity
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetus
Proteomesi
  • UP000189706 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000394421‹1 – 138NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialAdd BLAST›138

Post-translational modificationi

Dimethylation at Arg-118 by NDUFAF7 takes place after NDUFS2 assembles into the complex I, leading to stabilize the early intermediate complex.By similarity

Proteomic databases

PRIDEiP86250

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. Component of the iron-sulfur (IP) fragment of the enzyme. Interacts with NDUFAF3. Interacts with NDUFAF7.By similarity

Structurei

3D structure databases

SMRiP86250
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.Sequence analysis

Family and domain databases

Gene3Di1.10.645.20, 2 hits
InterProiView protein in InterPro
IPR001135 NADH_Q_OxRdtase_suD
IPR038290 NADH_Q_OxRdtase_suD_sf
IPR029014 NiFe-Hase_large
PfamiView protein in Pfam
PF00346 Complex1_49kDa, 2 hits
SUPFAMiSSF56762 SSF56762, 1 hit

Sequencei

Sequence statusi: Fragments.

P86250-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TYLQALPYFD RLLNIQPPPR EKMFEFYERM HAAYIRPGGV HQDLPLGLMD
60 70 80 90 100
DIYEFSKNFS LRIDEVEEML TNNRKTQPYD VYDQVEFDVP IGSRLYTEGY
110 120 130
QVPPGATYTA IEAPKGHMLA DVVAIIGTQD IVFGEIDR
Length:138
Mass (Da):15,937
Last modified:June 15, 2010 - v1
Checksum:i19CF54EF543A6495
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-adjacent residuesi11 – 12Curated2
Non-adjacent residuesi20 – 21Curated2
Non-adjacent residuesi29 – 30Curated2
Non-adjacent residuesi74 – 75Curated2
Non-adjacent residuesi94 – 95Curated2
Non-adjacent residuesi115 – 116Curated2

Entry informationi

Entry nameiNDUS2_MESAU
AccessioniPrimary (citable) accession number: P86250
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: March 28, 2018
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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