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P86250 (NDUS2_MESAU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 10. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

EC=1.6.5.3
EC=1.6.99.3
Alternative name(s):
Complex I-49kD
Short name=CI-49kD
NADH-ubiquinone oxidoreductase 49 kDa subunit
Gene names
Name:NDUFS2
OrganismMesocricetus auratus (Golden hamster)
Taxonomic identifier10036 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Protein attributes

Sequence length138 AA.
Sequence statusFragments.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. UniProtKB P17694

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

NADH + acceptor = NAD+ + reduced acceptor. UniProtKB P17694

Cofactor

Binds 1 4Fe-4S cluster By similarity. UniProtKB P17694

Subunit structure

Complex I is composed of 45 different subunits. Component of the iron-sulfur (IP) fragment of the enzyme. Interacts with NDUFAF3 By similarity. UniProtKB O75306

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity UniProtKB P17694.

Sequence similarities

Belongs to the complex I 49 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 138›138NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
PRO_0000394421

Experimental info

Non-adjacent residues11 – 122
Non-adjacent residues20 – 212
Non-adjacent residues29 – 302
Non-adjacent residues74 – 752
Non-adjacent residues94 – 952
Non-adjacent residues115 – 1162
Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P86250 [UniParc].

Last modified June 15, 2010. Version 1.
Checksum: 19CF54EF543A6495

FASTA13815,937
        10         20         30         40         50         60 
TYLQALPYFD RLLNIQPPPR EKMFEFYERM HAAYIRPGGV HQDLPLGLMD DIYEFSKNFS 

        70         80         90        100        110        120 
LRIDEVEEML TNNRKTQPYD VYDQVEFDVP IGSRLYTEGY QVPPGATYTA IEAPKGHMLA 

       130 
DVVAIIGTQD IVFGEIDR 

« Hide

References

[1]"Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa."
Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.
Asian J. Androl. 12:344-355(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP86250.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001135. NADH_Q_OxRdtase_suD.
[Graphical view]
PfamPF00346. Complex1_49kDa. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDUS2_MESAU
AccessionPrimary (citable) accession number: P86250
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: February 19, 2014
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families